Response Quantitative Trait Loci Unveiling Gene-Environment Interactions in Diseases [0.03%]
反应数量性状位点揭示疾病中的基因-环境相互作用
Yu Chen,Xueying Wang,Chao Chen
Yu Chen
Sex-Specific Alterations of the Kynurenine Pathway in Association With Risk for and Remission of Depression in Adolescence [0.03%]
青少年抑郁症发病和缓解与色氨酸代谢途径的性别差异性改变
Naghmeh Nikkheslat,Zuzanna Zajkowska,Cristina Legido-Quigley et al.
Naghmeh Nikkheslat et al.
Background: The imbalance between neurotoxic and neuroprotective metabolites of the kynurenine pathway has been implicated in the pathophysiology of major depressive disorder (MDD) in adulthood but has not been fully inve...
Andreas Horn,Ningfei Li,Garance M Meyer et al.
Andreas Horn et al.
In the field of deep brain stimulation (DBS), two major themes are currently making significant progress. First, the framework of connectomic DBS, in which circuits that are associated with improvements of specific symptoms are described an...
Low Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit their Clinical Utility [0.03%]
用于重大精神障碍的多基因风险评分缺乏稳定性和特异性，限制了其临床效用
Josephine Mollon,Laura M Schultz,Emma Em Knowles et al.
Josephine Mollon et al.
Background: There has been little examination of the stability and validity of polygenic risk scores (PRS) i.e., whether individuals identified as high-risk for a disorder with one PRS are identified as high-risk with ano...
Astrocytes control cocaine-induced synaptic plasticity and reward through the matricellular protein hevin [0.03%]
星形胶质细胞通过胞外基质蛋白hevin控制可卡因诱导的突触可塑性和奖赏效应
Raphaële Mongrédien,Augusto Anesio,Gustavo J D Fernandes et al.
Raphaële Mongrédien et al.
Background: Astrocytes in the nucleus accumbens (NAc) play a dynamic role in regulating synaptic plasticity induced by drugs of abuse through modulation of glutamatergic neurotransmission. Astrocyte-secreted factors may a...
Nicole Rigney,Weizhe Hong
Nicole Rigney
Prosocial helping behavior, characterized by voluntary actions taken to benefit others, plays a vital role in promoting cooperation and maintaining social bonds across human and animal social groups. In this review, we examine key conceptua...
Early manifestations of neurodevelopmental copy number variants in children: A population-based investigation [0.03%]
儿童神经发育拷贝数变异的早期表现：一项基于人群的研究
Charlotte A Dennison,Joanna Martin,Amy Shakeshaft et al.
Charlotte A Dennison et al.
Background: There is clinical interest in recognising copy number variants (CNVs) in children as many have immediate and long-term health implications. Neurodevelopmental CNVs are associated with intellectual disability, ...
Conduct disorder is associated with heightened action initiation and reduced learning from punishment but not reward [0.03%]
品行障碍与行动发起增强和惩罚学习减少但不是奖励学习有关
Ruth Pauli,Inti Brazil,Gregor Kohls et al.
Ruth Pauli et al.
Background: Theoretical and empirical accounts of conduct disorder (CD) suggest problems with reinforcement learning as well as heightened impulsivity. These two facets can manifest in similar behaviour, such as risk-taki...
Published Erratum
Biological psychiatry. 2025 Mar 14:S0006-3223(25)01010-8. DOI:10.1016/j.biopsych.2025.02.896 2025
Published Erratum
Biological psychiatry. 2025 Apr 1;97(7):753. DOI:10.1016/j.biopsych.2025.01.017 2025