Lessons from clinical trials of immunomodulatory drugs in psychiatric disorders [0.03%]
免疫调节药物在精神疾病临床试验中的经验教训
Thomas Pak,Nabila Haque,Manish K Jha
Thomas Pak
Immune dysregulation has been implicated in the pathophysiology of psychiatric disorders, with peripheral inflammatory markers correlating with symptom severity, treatment refractoriness, and neural circuit dysfunction. This has led to grow...
Depression as a disease of white matter network disruption: Learning from Multiple Sclerosis [0.03%]
抑郁症作为突触网络破坏的疾病：从多发性硬化症中吸取教训
Erica B Baller,Elena C Cooper,Matthew K Schindler et al.
Erica B Baller et al.
Depression is a common and debilitating psychiatric disorder that is associated with substantial morbidity and mortality. For nearly 40 years, scientists have attempted to localize depression in the brain with neuroimaging. Despite concerte...
Sebastian Hachenberg,Scott J Russo,Flurin Cathomas
Sebastian Hachenberg
Chronic stress is a major risk factor for several psychiatric disorders, including major depressive disorder and posttraumatic stress disorder. This review synthesizes rodent-based findings showing that stress modifies immune function in th...
Functional Plasticity of Orexin/Hypocretin Neurons Balances Stress States [0.03%]
下丘脑 orexin 神经元的功能可塑性调控应激反应状态
Jazmine D W Yaeger,Morgan H James,Cliff H Summers
Jazmine D W Yaeger
Orexin/hypocretin (Orx) peptides critically contribute to stress and arousal circuits' flexibility and equilibrium. New discoveries highlight plasticity of orexin neurons themselves, as well as plasticity-inducing properties of orexin pepti...
Halide Bilge Turkozer,Paulo Lizano,Carol A Tamminga et al.
Halide Bilge Turkozer et al.
The visual system, as one of the most well-understood components of the central nervous system, offers a unique framework for understanding mechanistic aspects of psychosis. This review explores the clinical translational potential of visua...
Robert James R Blair
Robert James R Blair
New Insights Into the Neurodevelopment of Conduct Disorder and Callous-Unemotional Traits in Males and Females [0.03%]
性别对儿童行为障碍神经发育影响的新见解
Elise M Cardinale,Abigail A Marsh
Elise M Cardinale