Transdiagnostic and Disorder-Level GWAS Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries [0.03%]
跨诊断和疾病水平的基因组广泛关联研究增强非洲和欧洲血统中物质使用及精神病遗传风险图谱的精确性
Yousef Khan,Christal N Davis,Zeal Jinwala et al.
Yousef Khan et al.
Background: Substance use disorders (SUDs) and psychiatric disorders frequently co-occur, and their etiology likely reflects both transdiagnostic (i.e., common/shared) and disorder-level (i.e., independent/nonshared) gene...
Brain Responses During Face Processing in Conduct Disorder: Considering Sex and Callous-Unemotional Traits [0.03%]
品行障碍患者面孔加工过程中的脑电反应：考虑性别和无情特征的影响
Stephane A De Brito,Jack C Rogers,Ruth Pauli et al.
Stephane A De Brito et al.
Functional magnetic resonance imaging (fMRI) studies of conduct disorder (CD) have mostly been limited to males. Here, we examined whether male and female youth with CD showed similar or distinct alterations in brain responses to emotional ...
Social Homeostasis: A New Paradigm for Mental Health Diagnosis and Treatment [0.03%]
社会稳态：精神卫生诊断与治疗的新范式
Aza Stephen Allsop,Kay M Tye,John H Krystal
Aza Stephen Allsop
Hierarchical Phenotyping of Psychopathology: Implications and Opportunities for Precision Psychiatry when Biology Could be Associated with both Symptoms and Syndromes [0.03%]
精神病学的分层表型分析：当生物学与症状和综合征相关时精准精神病学的意义及机遇
Daniel P Moriarity,Emily R Perkins,Keanan J Joyner
Daniel P Moriarity
As psychiatry increasingly embraces precision medicine principles, there has been increasing efforts to characterize the specificity of biology-psychopathology associations (e.g., is biology associated with syndromes or symptoms?). Unfortun...
Quantitative T1 mapping indicates elevated white matter myelin in children with RASopathies [0.03%]
量化T1映射显示RASopathies患儿的白质髓鞘增加
Julia R Plank,Elveda Gozdas,Jennifer Bruno et al.
Julia R Plank et al.
Background: Evidence suggests a pathological role of myelination in neurodevelopmental disorders with links to cognitive difficulties, but in vivo assessment remains challenging. Quantitative T1 mapping (QT1) has been use...
Marina Guizzetti,Regina A Mangieri,Lubov A Ezerskiy et al.
Marina Guizzetti et al.
Evidence for involvement of astrocytes in several neurodegenerative disorders and in drug addiction has been emerging over the last two decades, but only in recent years have astrocytes been investigated for their roles in alcohol use disor...
From Physiology to Psychiatry: Key role of vagal interoceptive pathways in emotional control [0.03%]
从生理学到精神病学：迷走神经内感受通路在情绪控制中的关键作用
Jean-Philippe Krieger,Karolina P Skibicka
Jean-Philippe Krieger
Interoception is the awareness of bodily sensations, conveyed by both hormonal and neural signals. The vagus nerve is the primary neural interoceptive conduit, responsible for transmitting information from peripheral organs to the brain. It...
Astrocyte-synapse structural plasticity in neurodegenerative and neuropsychiatric diseases [0.03%]
神经退行性疾病和神经精神疾病中的星形胶质细胞突触结构可塑性
Aina Badia-Soteras,Aline Mak,Thomas M Blok et al.
Aina Badia-Soteras et al.
Synaptic dysfunction is a common feature across a broad spectrum of brain diseases, spanning from psychopathologies such as post-traumatic stress disorder (PTSD) and substance use disorders (SUD) to neurodegenerative diseases like Alzheimer...
Social stress increases anxiety by GluA1-dependent synaptic strengthening of ventral tegmental area inputs to the basolateral amygdala [0.03%]
社会压力通过伏隔核投射到基底外侧杏仁核的AMPA受体介导的突触强化促进焦虑反应
Thomas Contesse,Joana Gomes-Ribeiro,Lea Royon et al.
Thomas Contesse et al.
Background: Brain defensive mechanisms evolved to maintain low levels of state anxiety. However, risk factors such as stress exposure shifts activity within defensive circuits, resulting in increased anxiety. The amygdala...
Longitudinal associations between greenspace exposure, structural brain development, and mental health and academic performance during early adolescence [0.03%]
绿地暴露与青少年早期大脑结构发育及心理健康和学业成绩的纵向关联研究
Qingyang Li,Sarah Whittle,Divyangana Rakesh
Qingyang Li
Background: Greenspace exposure is associated with positive mental health and academic outcomes. This preregistered longitudinal study examines whether the influence of greenspace exposure on structural brain development ...