FDG-PET as a pre-operative biomarker for predicting and optimizing response to subcallosal cingulate area deep brain stimulation [0.03%]
术前生物标志物FDG-PET在预测和优化胼胝体下扣带回深部脑刺激反应中的作用
Gavin J B Elias,Sarah A Iskin,Michelle E Beyn et al.
Gavin J B Elias et al.
Background: Deep brain stimulation targeting the subcallosal cingulate area (SCC-DBS) has emerged as a promising therapy for treatment-resistant depression (TRD). However, only half to two thirds of patients experience me...
Stage-dependent Neural Mechanisms in Human Methamphetamine Abstinence: Insights from the Digital Twin Brain Model [0.03%]
数字孪生脑模型揭示的人类冰毒戒断不同时期的神经机制
Jiaqi Zhang,Yanyao Du,Jin Li et al.
Jiaqi Zhang et al.
Background: The reward circuits are crucial in treating human methamphetamine (MA) addiction, while the underlying action mechanisms may vary throughout the intervention process. This gap limits the identification of spec...
Chronobiology of Mood Disorders: The Role of the biological clock in Depression and Bipolar Disorder [0.03%]
心境障碍的生物节律学：生物钟在抑郁及双相情感障碍中所扮演的角色
Pierre A Geoffroy,Julia Maruani
Pierre A Geoffroy
Mood disorders, including major depressive disorder (MDD), bipolar disorder (BD), and seasonal affective disorder (SAD), exhibit significant heterogeneity, with disturbances in biological rhythms playing a central role. These disturbances n...
From Brain Network Dysfunction to Neuropsychiatric Symptoms in Alzheimer's Disease [0.03%]
阿尔茨海默病从脑网络功能障碍到神经精神症状表型的转变
Maria Vasileiadi,Sean Michael Nestor
Maria Vasileiadi
Mechanistic and Predictive Implications of Transdiagnostic Features of the Connectome [0.03%]
共病特征的连接组的机制和预测意义
Jose M Rubio,Elvisha Dhamala
Jose M Rubio
Unlocking Alzheimer's Disease Heterogeneity: The Role of Normative Modeling, Dynamic Connectivity, and Beyond [0.03%]
解析阿尔茨海默病的异质性：规范建模、动态连接及其他因素的作用
Qian Wang,Shile Qi,Rongtao Jiang et al.
Qian Wang et al.
Postnatal and juvenile fluoxetine treatment evokes sex-specific, opposing effects on mood-related behavior, gene expression, mitochondrial function, and dendritic architecture in the rat medial prefrontal cortex [0.03%]
产后和青春期舍曲林治疗在大鼠前额叶皮层中诱发性别特异的、相反的影响：情绪相关行为、基因表达、线粒体功能及树突结构
Utkarsha Ghai,Parul Chachra,Suchith Mendon et al.
Utkarsha Ghai et al.
Background: Serotonin shapes emotional neurocircuit development, and serotonergic neurotransmission is implicated in both the pathophysiology and treatment of neuropsychiatric disorders. The selective serotonin reuptake i...
Parsing clinical and neurobiological sources of heterogeneity in depression [0.03%]
解析抑郁症临床和神经生物学异质性的来源
Kayla Hannon,Ty Easley,Wei Zhang et al.
Kayla Hannon et al.
Background: Patients with depression vary from one-another in their clinical and neuroimaging presentation, yet the relationship between clinical and neuroimaging sources of variation is poorly understood. Determining sou...
Generative AI Models for Developing Neuroimaging Markers of Psychiatric Disorders [0.03%]
用于开发精神疾病神经影像标志物的生成式AI模型
Chadi G Abdallah,David van Dijk
Chadi G Abdallah
Thalamo-cortical structural co-variation networks are related to familial risk for schizophrenia in the context of lower nuclei volume estimates in patients: an ENIGMA study [0.03%]
利用ENIGMA研究探讨较低核体积估计患者的 schizophrenia遗传风险下的丘脑皮层结构共变异网络
Annalisa Lella,Linda A Antonucci,Roberta Passiatore et al.
Annalisa Lella et al.
Background: Structural brain differences in the thalamus and the cortex have been widely reported in schizophrenia (SCZ) relative to neurotypical controls (NC). Most prior studies examined the thalamus as a whole, single ...