Sleep spindle abnormalities as neurophysiological biomarkers of Schizophrenia spectrum disorders: From cellular mechanisms and neural circuits to clinical implications [0.03%]
睡眠纺锤体异常作为精神分裂症谱系障碍的神经生理生物标志物：从细胞机制和神经环路到临床意义
Anna Castelnovo,Armando D&#x;Agostino,Ahmad Mayeli et al.
Anna Castelnovo et al.
Although not included in current diagnostic criteria, sleep disturbances are common in patients with schizophrenia (SCZ) and significantly impact their cognitive function and clinical outcomes. Among sleep disturbances, abnormalities in sle...
Paradoxical ventral tegmental area GABA signaling drives enhanced morphine reward after adolescent nicotine [0.03%]
青春期尼古丁诱发的矛盾性腹侧被盖区多巴胺能神经环路与阿片奖赏增强效应
Ruthie E Wittenberg,Sanghee Yun,Kechun Yang et al.
Ruthie E Wittenberg et al.
Background: An important yet poorly understood risk factor for opioid use disorder is adolescent nicotine use. We investigated the neural mechanisms underlying this understudied interaction. ...
Vascular homeostasis in suicidal behavior: from molecular mechanisms to clinical implications [0.03%]
自杀行为中的血管稳态：从分子机制到临床意义
Aiste Lengvenyte,Philippe Courtet
Aiste Lengvenyte
Suicidal behaviors (SB) remain a major global health challenge, reflecting persistent gaps in understanding their neurobiological underpinnings. The scarcity of validated biological markers for diagnosis, prediction, or treatment response i...
Why is Clozapine uniquely Effective in Treatment Resistant Schizophrenia? [0.03%]
氯氮平为何对难治性精神分裂症独具疗效？
Robin M Murray,Alice Egerton,Yueming Gao et al.
Robin M Murray et al.
Much is known about the use, benefits, and side-effects, of clozapine in treatment resistant schizophrenia (TRS). However, why clozapine is more effective than other antipsychotics in TRS remains unclear. This paper addresses this question....
Unraveling the Neurovisual Interconnection and Threat Processing in Posttraumatic Stress Disorder: New Perspectives and Future Directions [0.03%]
解密创伤后应激障碍的神经视觉联结和威胁处理：新视角与未来方向
Rizky Andana Pohan,Dian Oktary,Siti Kulsum et al.
Rizky Andana Pohan et al.
Susmita Malwade,Andres Ingason,Konstantin Khodosevich
Susmita Malwade
Copy number variants (CNVs) are structural genomic rearrangements that alter the number of gene copies in genome. Some CNVs are highly penetrant for psychiatric disorders, where the total CNV impact to a neuropsychiatric phenotype is based ...
Successful Evidence-Based Parenting Programs are Associated With Brain Changes and Improved Reward Processing in Boys With Conduct Problems [0.03%]
有效的基于证据的育儿项目与具有行为问题的男孩大脑变化和改善的奖励处理有关
Arjun Sethi,Suzanne O&#x;Brien,James Blair et al.
Arjun Sethi et al.
Background: Early parenting interventions are the gold standard treatment for reducing antisocial behaviour (ASB) in children with conduct problems (CP), but the neurocognitive mechanisms underpinning treatment response a...
A Longitudinal and Reproducible Anti-coactivation Pattern Between the Cerebellum and the Ventral Tegmental Area Relates to Apathy in Schizophrenia [0.03%]
一项纵向可验证的精神分裂症患者小脑与中脑腹侧被盖区反向协同活化模式的研究：相关性及其临床意义
Jade Awada,Farnaz Delavari,Thomas A W Bolton et al.
Jade Awada et al.
Background: Negative symptoms of schizophrenia lack effective treatments. Anomalies in the reward system and cerebellum have been linked to these symptoms. The cerebellum modulates reward circuitry via the ventral tegment...
Effect of natural rewards on substance use disorder: an incentive sensitization perspective [0.03%]
自然奖赏对物质使用障碍的影响：动机敏感化的视角
Wei Zheng,Xiaoxing Liu,Tangsheng Lu et al.
Wei Zheng et al.
In substance use disorder (SUD)/drug addiction, individuals often seek drug rewards at a large cost. Recent findings demonstrate that natural rewards may offer significant therapeutic potential against SUD. However, the mechanism by which n...
Network localization of functional brain changes associated with ketamine's therapeutic effects in depression [0.03%]
与氯胺酮治疗效应相关的抑郁功能脑改变的网络定位学研究
Shaoqiang Han,Ya Tian,Huiting Yang et al.
Shaoqiang Han et al.
Background: Although numerous studies have attempted to identify the functional pathways underlying the rapid antidepressant effects of ketamine, their findings remain inconsistent, limiting our understanding of the neura...