Energy-landscape analysis of brain network dynamics in a multi-center Alzheimer's disease and mild cognitive impairment cohort [0.03%]
多中心阿尔茨海默病和轻度认知障碍队列的大脑网络动力学的能景分析
Rixing Jing,Peng Li,Kun Zhao et al.
Rixing Jing et al.
Convergent dynamic functional connectivity studies have demonstrated their potential as a hallmark for capturing the impairments in brain function associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, unders...
Lifespan Normative Models of White Matter Fractional Anisotropy: Applications to Early Psychosis [0.03%]
lifespan normative模型在精神分裂症前发病阶段的应用研究白质分数各向异性
Ramona Cirstian,Natalie J Forde,Gary Zhang et al.
Ramona Cirstian et al.
Background: This study presents large-scale normative models of white matter (WM) organization across the lifespan, using diffusion MRI data from over 25,000 healthy individuals aged 0-100 years. These models capture life...
Urolithin A abolishes high anxiety and rescues the associated mitochondria-related transcriptomic signatures and synaptic function [0.03%]
尿石素A消除过高焦虑并修复相关的线粒体转录组特征和突触功能
David Mallet,Doğukan Hazar Ülgen,Jocelyn Grosse et al.
David Mallet et al.
Background: Chronic anxiety is common, disabling, and often refractory to current therapies. Mounting evidence implicates mitochondrial abnormalities in anxiety-related phenotypes. Urolithin A (UA), a gut microbiota-deriv...
Published Erratum
Biological psychiatry. 2025 Jul 30:S0006-3223(25)01347-2. DOI:10.1016/j.biopsych.2025.07.009 2025
Activity of corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis reduces anxiety-potentiated startle in female rats in an estrous phase-dependent manner [0.03%]
终丝床核催产素神经元的活性以动情周期阶段依赖性的方式降低雌性大鼠受焦虑驱动的惊跳反应活动
Rachel Chudoba,Joanna Dabrowska
Rachel Chudoba
Background: The prevalence of post-traumatic stress disorder (PTSD) and anxiety disorders is higher in women than men. The severity of hallmark symptoms including hypervigilance and fear reactivity to unpredictable threat...
Efficacy and Safety of Accelerated Intermittent Theta-burst Stimulation for Adolescents with Major Depressive Disorder: A Randomized, Double-Blind, Sham-controlled study [0.03%]
青少年抑郁症间歇θ爆发刺激加速治疗的疗效和安全性：一项随机双盲假刺激对照研究
Xiaoli Liu,Ziyang Peng,Fang Cheng et al.
Xiaoli Liu et al.
Background: Developing safe and rapid treatments is crucial for adolescent major depressive disorder (MDD). While 10-session daily accelerated intermittent theta burst stimulation (a-iTBS) is effective in adults, its dura...
Transposable elements are dynamically regulated in medium spiny neurons and may contribute to the molecular and behavioral adaptations to cocaine [0.03%]
可移动元件在中棘神经元中的动态调节及其对可卡因分子和行为适应性的潜在贡献
Gabriella M Silva,Amber L Kaplan,Celeste R Park et al.
Gabriella M Silva et al.
Background: Earlier work has established that Zfp189, which encodes a KZFP transcription factor (TF), differentially accumulates in nucleus accumbens (NAc) Drd1+ and Drd2+ medium spiny neurons (MSNs) and drives MSN functi...
Can Insight Into Neurodevelopmental Aspects in Bipolar Disorders Facilitate Precision Psychiatry Approaches? [0.03%]
神经发育方面的心得能否促进精准精神病学的方法？
Mirko Manchia,Ole A Andreassen
Mirko Manchia
Compulsive coping behaviour, developed predominantly by sign-trackers, is exacerbated by chronic atomoxetine [0.03%]
慢性阿托莫西汀加剧由主要追踪信号的行为强迫应对方式
Chloe S Chernoff,Aude Belin-Rauscent,Mickaël Puaud et al.
Chloe S Chernoff et al.
Background: Loss of control over coping strategies can result in the development of impulsive/compulsive spectrum disorders (ICSDs) such as obsessive-compulsive disorder or trichotillomania. Rats, like humans, show indivi...
Left and Right Hemispheric Lateralization as an Overlooked Variable in Psychiatric Disease: Evidence Across Species [0.03%]
左右半球 lateralization 在精神病学疾病中被忽视的变量：跨物种证据
Michael Ojo,Heather N Allen,Benedict Kolber
Michael Ojo
Despite centuries of reports documenting both anatomical and functional brain asymmetries, lateralization as an experimental variable remains largely overlooked in preclinical studies focusing on psychiatric disorders. Recent work has ident...