Investigating Shared Cardiovascular Factors and Genetic Overlap of Pregnancy-Related Disorders, Major Depressive Disorder, and Alzheimer's Disease [0.03%]
探究心血管相关因素及妊娠并发症、重度抑郁症和阿尔茨海默病的遗传重叠现象
Hannah Oppenheimer,Alexey Shadrin,Jonas Ø Andersen et al.
Hannah Oppenheimer et al.
Background: Pregnancy-related disorders, such as hypertensive disorders of pregnancy (HDP) and postpartum depression, have consequences for maternal health, increasing risk for major depressive disorder (MDD) and Alzheime...
GABAergic neuroactive steroids and network states: relevance to peripartum depression [0.03%]
γ-氨基丁酸神经活性类固醇和网络状态：与围产期抑郁的相关性
Jamie Maguire,Pantelis Antonoudiou,Kristina M Deligiannidis
Jamie Maguire
The Food and Drug Administration's approval of allopregnanolone analogs, which function as positive allosteric modulators at GABAA receptors, for the treatment of postpartum depression is a major advance in neuroscience research and psychia...
Transcriptional profiling of the cortico-accumbal pathway reveals sex-specific alterations underlying stress susceptibility [0.03%]
纹状体通路的转录组学揭示了应激易感性的性别差异性改变
André Moreira Pessoni,Laila Blanc-Arabe,Luca Pancotti et al.
André Moreira Pessoni et al.
Background: Anxiety and depressive disorders, including major depressive disorder (MDD), affect millions of people every year, imposing significant socio-economic burdens and highlighting the need to better understand the...
Sex differences in brain cell-type specific chromatin accessibility in schizophrenia [0.03%]
精神分裂症中与性别相关的特定脑细胞类型染色质可及性差异研究
Yixuan Ma,Kiran Girdhar,Gabriel E Hoffman et al.
Yixuan Ma et al.
Background: Our understanding of the sex-specific role of the non-coding genome in serious mental illnesses, particularly schizophrenia (SCZ), remains largely incomplete. ...
A framework for advancing mechanistic neuro-behavioral biomarkers in psychiatry [0.03%]
精神病学中推进机制神经行为生物标志物的框架
Kangjoo Lee,Jie Lisa Ji,Markus Helmer et al.
Kangjoo Lee et al.
Neuropsychiatry has yet to surmount the fundamental challenge of mapping behavioral pathology to its underlying neural pathology. This gap limits the development of treatments for specific circuit pathologies, despite the great potential of...
Paul C Fletcher,Trevor W Robbins
Paul C Fletcher
Thomas A Pollak
Thomas A Pollak
A tale of two receptors: simultaneous targeting of NMDARs and 5-HT4Rs exerts additional effects against stress [0.03%]
双重受体的传奇：NMDAR和5-HT4R的协同靶向作用对压力产生附加效应
Briana K Chen,Michelle Jin,Gergely F Turi et al.
Briana K Chen et al.
Background: Serotonin (5-HT) receptors and N-methyl-D-aspartate receptors (NMDARs) have been implicated in the pathophysiology of depression and anxiety disorders. Here, we evaluated whether targeting both receptors throu...
Task and resting state fMRI modelling of brain-behavior relationships in developmental cohorts [0.03%]
发育队列中任务和静息态fMRI对脑-行为关系的建模研究
Lucina Q Uddin,Hugh Garavan
Lucina Q Uddin
Functional magnetic resonance imaging (fMRI) data are often used to inform individual differences in cognitive, behavioral, and psychiatric phenotypes. These so-called "brain-behavior" association studies come in many flavors and are increa...