Human Pluripotent Stem Cell-Derived Hematopoietic Progenitors and Mature Cells [0.03%]
人多能干细胞来源的血细胞祖细胞和成熟细胞
Christopher Sturgeon,Eirini Papapetrou,Shannon McKinney-Fridman
Christopher Sturgeon
The diagnostic and therapeutic potential of multiple myeloma-associated circular RNAs [0.03%]
多重(my)浆细胞瘤相关环形RNA的诊断和治疗潜能分析
Yue Zhao,Shaokun Wang,Shuang Fu et al.
Yue Zhao et al.
Circular RNA (circRNA) was first discovered in viruses in 1974, they are primarily formed through back-splicing, where a downstream splice donor is joined to an upstream splice acceptor, resulting in a closed circRNA transcript. Under norma...
Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging? [0.03%]
重新审视年龄相关血液系统疾病的“惯犯”：干细胞功能障碍是衰老的根本原因吗？
Foteini Fotopoulou,Esther Rodriguez-Correa,Charles Dussiau et al.
Foteini Fotopoulou et al.
Aging exerts a profound impact on the hematopoietic system, leading to increased susceptibility to infections, autoimmune diseases, chronic inflammation, anemia, thrombotic events, and hematologic malignancies. Within the field of experimen...
The inhibitory receptor PVRIG is dominantly expressed in the bone marrow of patients with multiple myeloma and its blockade enhances T-cell engager's immune activation [0.03%]
髓系肿瘤患者骨髓中的抑制性分子PVRIG的表达及其阻断促进双特异性抗体介导的T细胞活化
Masha Frenkel,Zoya Alteber,Ning Xu et al.
Masha Frenkel et al.
Therapeutic advances in treating patients with multiple myeloma (MM), including novel immunotherapies, have improved the disease control, but it remains incurable. Although traditional immune check point inhibitors have shown limited clinic...
Understanding Human Oncogene Function and Cooperativity in Myeloid Malignancy Using iPSCs [0.03%]
利用诱导多能干细胞理解人类癌基因功能及髓系肿瘤中的协同作用
Martina Sarchi,Sergei Doulatov
Martina Sarchi
Myeloid malignancies are a spectrum of clonal disorders driven by genetic alterations that cooperatively confer aberrant self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs). Induced pluripotent stem cells (iP...
Tomohiro Yabushita,Susumu Goyama
Tomohiro Yabushita
Nucleic acid analogs, including cytarabine, decitabine, and azacitidine, have significantly advanced therapeutic approaches for myeloid tumors over the past five decades. Nucleic acid metabolism is a crucial pathway driving myeloid tumorige...
Andrew Adel Guirguis
Andrew Adel Guirguis
RNA methylation and the machinery that regulates or "reads" its expression has recently been implicated in the pathogenesis of acute myeloid leukemia (AML) and other hematologic malignancies. Modulation of these epigenetic marks has started...
John D Crispino
John D Crispino
Joanna H Greenman,Lucie Moss,Shinjini Chakraborty et al.
Joanna H Greenman et al.
Schistosomiasis afflicts >250 million people worldwide, leading to an annual loss of >3 million disability-adjusted life years. Schistosoma mansoni causes intestinal schistosomiasis with parasite eggs either transversing intestinal tissue o...
Sex-stratified association of variants in the serotonin 1A receptor gene with acute crisis pain among African American patients with sickle cell disease [0.03%]
血清素1A受体基因多态性与非洲裔美国人镰状细胞病急性危象疼痛的关系
Nilanjana Sadhu,Ying He,Yavnika Kashyap et al.
Nilanjana Sadhu et al.
Patients with sickle cell disease (SCD) experience pain in their daily lives. Both the acute and chronic pain phenotypes of this disease exhibit high variability, making pain management a challenge. The underlying reasons for the phenotypic...