D816V KIT mutation induces mitochondrial morphologic and functional changes through BNIP3 downregulation in human myeloid cell lines ROSA and TF-1 [0.03%]
D816V突变通过下调BNIP3诱导人髓系细胞系ROSA和TF-1中的线粒体形态和功能变化
S Cisa-Wieczorek,M I Hernández-Alvarez,M Parreño et al.
S Cisa-Wieczorek et al.
The KIT receptor is a transmembrane protein found on the surface of many different cell types. Mutant forms of KIT are drivers of myeloid neoplasms, including systemic mastocytosis. The KIT D816V mutation is the most common, leading to cons...
Bone marrow niches for hematopoietic stem cells in homeostasis and aging [0.03%]
造血干细胞的骨髓生态位：从组织平衡到衰老
Taichi Nakatani,Takashi Nagasawa
Taichi Nakatani
Among various types of candidate cells, including osteoblasts and Nestin+ periarteriolar cells, several lines of histological and genetic evidence have demonstrated that the single population of mesenchymal stem cells, termed CXC chemokine ...
Preconditioning intervention prior to allogeneic hematopoietic stem cell transplantation in patients with high-risk acute myeloid leukemia [0.03%]
高危急性髓系白血病患者异基因造血干细胞移植前的预处理干预措施
Takayoshi Tachibana,Akihiko Izumi,Shota Arai et al.
Takayoshi Tachibana et al.
The outcomes of patients with high-risk acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (HCT) remain poor despite many attempts at developing therapeutic strategies. Preconditioning interventions (PCIs)...
KLF4 enhances transplantation-induced hematopoiesis by inhibiting TLRs and non-canonical NFκB signaling at a steady state [0.03%]
KLF4通过抑制稳态下的TLR和非经典NF-κB信号通路来增强移植诱导的造血功能
Chun Shik Park,Cory S Bridges,Andrew H Lewis et al.
Chun Shik Park et al.
The transcription factor Krüppel-like factor 4 (KLF4) acts as a transcriptional activator and repressor. KLF4 plays a role in various cellular processes, including the dedifferentiation of somatic cells into induced pluripotent stem cells....
Methodological Considerations on How to Identify Human Hematopoietic Stem Cells [0.03%]
关于如何鉴定人类造血干细胞的研究方法学考虑因素
Taylor Hinchly,Dominique Bonnet,Fernando Anjos-Afonso
Taylor Hinchly
Recently, human CD34+ hematopoietic stem cells (HSCs) have been purified to a frequency of approximately 1 in 3 cells, a population denoted as CD34+CD38-CD45RA-CD90±EPCR+ HSCs. This work aimed to evaluate the methodology for CD34+ HSC isol...
TET2-loss enhances immediate and time-resolved IFNγ signaling responses across myeloid differentiation [0.03%]
TET2缺失增强粒系分化过程中即刻和延时IFNγ信号反应
Matthew T Jenkins,Yunli E Chu,Alana M Franceski et al.
Matthew T Jenkins et al.
Signaling responses to cytokines are disrupted in clonal hematopoiesis and myeloid malignancies. To better identify specific signaling response alterations in the presence or absence of TET2, we developed a 36-parameter CyTOF panel of both ...
A Distinct Alternative mRNA Splicing Profile Identifies the Oncogenic CD44 Transcript Variant 3 in KMT2A-Rearranged Pediatric T-cell Acute Lymphoblastic Leukemia Cells [0.03%]
一种独特的选择性CDNA剪接模式可识别KMT2A重排儿童T细胞急性淋巴细胞白血病细胞中致癌的CD44转录变异体3
Amanda Ramilo Amor,Sabina Enlund,Indranil Sinha et al.
Amanda Ramilo Amor et al.
T-cell acute lymphoblastic leukemia (T-ALL), which constitutes of 10-15% of all pediatric ALL cases, is known for its complex pathology due to pervasive genetic and chromosomal abnormalities. Although most children are successfully cured, c...
How age affects human hematopoietic stem and progenitor cells and strategies to mitigate HSPC aging [0.03%]
年龄对人类造血干细胞和祖细胞的影响及缓衰策略研究
Xueling Li,Jianwei Wang,Linping Hu et al.
Xueling Li et al.
Hematopoietic stem cells (HSCs) are central to blood formation and play a pivotal role in hematopoietic and systemic aging. With aging, HSCs undergo significant functional changes, such as an increased stem cell pool, declined homing and re...