Patterns of hemolysis, erythropoiesis, and iron distribution define unique disease trajectories in three mouse models of genetic anemia [0.03%]
溶血、红细胞生成及铁分布的规律确定了遗传性贫血小鼠模型中的独特疾病发展轨迹
Irina L Dubach,Raphael M Buzzi,Dominik J Schaer et al.
Irina L Dubach et al.
Hemolytic anemias involve premature red blood cell (RBC) destruction and present complex phenotypes, including disturbances in iron metabolism, extramedullary erythropoiesis, and systemic organ involvement. To guide the selection of appropr...
Bcl7b and Bcl7c Subunits of BAF Chromatin Remodeling Complexes are Largely Dispensable for Hematopoiesis [0.03%]
BAF染色质重塑复合体亚基Bcl7b和Bcl7c在血液发育过程中大多是可以缺失的
Pierre Priam,Veneta Krasteva,Alexandre Polsinelli et al.
Pierre Priam et al.
Chromatin remodelers have emerged as prominent regulators of hematopoietic cell development and potential drivers of various human hematological malignancies. ATP-dependent BAF chromatin remodeling complexes, related to yeast SWI/SNF, deter...
Corrigendum to A novel lymphoid progenitor cell population (LSKlow) is restricted by p18INK4c Experimental Hematology Volume 44 Issue 9 (2016), 874-844.e5 [0.03%]
p18INK4c限制的新淋巴系祖细胞群(LSKlow)实验血液学(2016年,第44卷,第9期,874-844. e5)的勘误表
Fang Dong,Sha Hao,Shihu Ma et al.
Fang Dong et al.
Published Erratum
Experimental hematology. 2025 Apr 1:104770. DOI:10.1016/j.exphem.2025.104770 2025
Ex vivo modelling reveals low levels of CKS1 inhibition boost haematopoiesis via AKT/Foxo1 signalling [0.03%]
体外建模显示低水平的CKS1抑制通过AKT/Foxo1信号通路促进造血作用
Juliana Fabiani Miranda,Adam Rogerson,Megan Guthrie et al.
Juliana Fabiani Miranda et al.
Hematopoietic stem cells (HSCs) are rare cells residing at the top of the haematopoietic hierarchy capable of reconstituting all blood cell populations through their ability of self-renewal and differentiation. Their ability to maintain hae...
Establishing a low-dose x-ray irradiation protocol for experimental acute Graft-versus-Host disease [0.03%]
用于实验性急性移植物抗宿主病的低剂量x射线照射方案的建立
Michelle Klesse,Oliver Schanz,Annkristin Heine
Michelle Klesse
The investigation of Graft-versus-Host disease after allogeneic stem cell transplantation heavily relies on the use of experimental animal models and total body irradiation (TBI) as a conditioning regimen. However, 137Cs is gradually being ...
Assessing the Impact of Cell Isolation Method on B cell Gene Expression using Next-Generation Sequencing [0.03%]
使用下一代测序评估细胞分离方法对B细胞基因表达的影响
Amanda N Henning,Jordan Pardoe,Darryl Owusu-Ansah et al.
Amanda N Henning et al.
Transcriptional profiling of PBMCs is a widely explored research approach across multiple fields. Cell populations of interest are generally isolated prior to analysis, especially if low frequency cell populations are desired. B cells, in p...
HARNESSING THE POTENTIAL OF GENE EDITING TECHNOLOGY TO OVERCOME THE CURRENT BOTTLENECKS OF CAR-T CELL THERAPY IN T-CELL MALIGNANCIES [0.03%]
利用基因编辑技术的潜力来克服T细胞恶性肿瘤中CAR-T细胞治疗当前遇到的瓶颈问题
Ahmed H Ismail,Mohsen A Khormi,Wedad Mawkili et al.
Ahmed H Ismail et al.
T-cell malignancies (TCMs) include a diverse spectrum of hematologic cancers marked by complex biology and aggressive nature. Treating TCMs remains a critical unmet need in oncology with poor response to standard therapies. Chimeric antigen...
Advantages and challenges of ex vivo generation and expansion of human hematopoietic stem cells from pluripotent stem cells [0.03%]
来自多能干细胞的造血干细胞体外生成和扩展的优势与挑战
Min Ding,Yu Lu,Quan-Kai Lei et al.
Min Ding et al.
Hematopoietic stem cell transplantation (HSCT) is an essential and increasing therapeutic approach for treating conditions such as leukemia, lymphoma, and other blood cancers. However, its widespread use faces significant challenges, includ...
Anthony D Ho
Anthony D Ho
Sex differences alter primitive progenitors in the C57BL/6 Tet2 knockout mouse model [0.03%]
C57BL/6 Tet2敲除小鼠模型中性别差异改变原始前体细胞
Samantha M Holmes,Christopher J Wells,Christine Hall et al.
Samantha M Holmes et al.
The precancerous expansion of hematopoietic cells, termed clonal hematopoiesis (CH), has been correlated to disease development and all-cause mortality. Despite multiple observations that hematopoietic stem cell and progenitors (HSPCs) are ...