NAMPT-mediated deacetylation of HCLS1 protein promotes clonogenic growth of pediatric CML cells [0.03%]
NAMPT介导的HCLS1蛋白脱乙酰化促进儿童CML细胞克隆生长
Bardia Samareh,Olga Klimenkova,Narges Aghaallaei et al.
Bardia Samareh et al.
Pediatric chronic myeloid leukemia (CML) is a rare hematological malignancy with biological features that differ from that of adult patients. In pediatric CML patients the burden of tumor cells is higher resulting in a delayed achievement o...
Notch1 activation and inhibition in T cell acute lymphoblastic leukemia subtypes [0.03%]
T细胞急性淋巴细胞白血病亚型中的Notch1活化和抑制
Jiawen Lu,Xiuhua Xue,Haitao Wang et al.
Jiawen Lu et al.
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy caused by the accumulation of genomic lesions that affect the development of T cells. Notch1 signaling controls the expression of numerous T-lineage genes...
Mtg16 NHR1 mutations cause defects in lymphopoiesis and the response to anemia [0.03%]
MTG16/NHR1突变导致淋巴细胞生成缺陷和对贫血的抵抗能力下降
Monica Bomber,Pankaj Acharya,Anna E Johnson et al.
Monica Bomber et al.
The ETO/MTG family of transcriptional co-repressors play a key role in adult stem cell function across multiple tissues and may be affected by mutation, deletion or translocation in solid tumors and leukemia. Structural studies of the first...
Large-Scale Mediator Mendelian Randomization Analysis Identifies Multiple Immune Cells Mediating the Causal Link Between Gut Microbes and Chronic Graft-Versus-Host Disease Risk [0.03%]
大规模中介孟德尔随机化分析确定了多种免疫细胞介导肠道微生物与慢性移植物抗宿主病风险的因果联系
Yiyin Chen,Xinghao Yu,Yiming Cai et al.
Yiyin Chen et al.
Objective: Disorders of gut microbiota and immune cells have been observed to involve in the occurrence of chronic graft-versus-host disease (cGVHD) following unrelated HLA-matched donor transplantation, but their causal ...
Distinct transcriptional changes in hematopoietic progenitor subsets upon LPS-induced emergency granulopoiesis [0.03%]
LPS诱导应急粒细胞生成过程中造血祖细胞亚群的转录变化
Sladjana Kosanovic,Karolina Vanickova,Mirko Milosevic et al.
Sladjana Kosanovic et al.
Emergency granulopoiesis is a critical process by which hematopoietic progenitors and stem cells facilitate enhanced granulocytic production during severe infections. However, the role of distinct multipotent progenitors (MPPs) at early sta...
Hematopoietic Stem Cells in Human Fetal Liver Selectively Express CD49f [0.03%]
人类胎儿肝脏中的造血干细胞选择性地表达CD49f
Margarita E MacAldaz,Jeremy Shu,Glenn Edin et al.
Margarita E MacAldaz et al.
Identification of phenotypes of human hematopoietic cells that display long-term mature cell outputs in vitro and repopulating capability in immunodeficient mice has been important to anticipating the therapeutic potential of fresh harvests...
Development and aging of resident endothelial stem cells in pre-existing blood vessels [0.03%]
存在于原有血管中的居民内皮干细胞的发育和衰老
Fitriana N Rahmawati,Nobuyuki Takakura
Fitriana N Rahmawati
Organ-specific somatic stem cells play an important role in supporting tissue turnover and facilitating regeneration upon injury. Hematopoietic stem cells are one of the most established organ-specific somatic cells that have been frequentl...
C-COUNT: a Convolutional Neural Network-Based Tool for Automated Scoring of Erythroid Colonies [0.03%]
基于卷积神经网络的红系集落自动评分工具C-COUNT
Rui Li,Ashley Winward,Logan R Lalonde et al.
Rui Li et al.
In spite of advances in flow cytometry and single-cell transcriptomics, colony formation assays remain an essential component in the evaluation of erythroid and hematopoietic progenitors. These assays provide functional information on proge...
Engineered cytokine-expressing MSCs support ex vivo culture of human HSPCs and AML cells [0.03%]
工程化细胞因子分泌的间充质干细胞支持人多能干细胞和急性髓系白血病细胞体外培养
Johannes Foßelteder,Thomas Brauchart,Angelika Schlacher et al.
Johannes Foßelteder et al.
CD34+ human hematopoietic stem and progenitor cells (HSPCs) and primary patient-derived leukemia cells are important tools for basic and translational research. Their limited availability demands additional expansion ex vivo in many cases. ...
Unbiased analysis of NUP98-KDM5A-induced murine leukemia reveals phenotypic heterogeneity recapitulating human disease subtypes [0.03%]
无偏倚分析NUP98-KDM5A诱导的小鼠白血病表型揭示其异质性并模拟人类疾病亚型
Marilaine Fournier,Marion Dubuissez,Mathieu Neault et al.
Marilaine Fournier et al.
NUP98-KDM5A (NK5) is an oncogenic fusion protein implicated in the development of several types of acute myeloid leukemia (AML) in humans, including rare pediatric acute megakaryoblastic leukemia (AMKL). NK5 expression in murine hematopoiet...