Balancing Hematopoietic Stem Cell Self-renewal and Differentiation Activities Throughout Ontogeny and Aging [0.03%]
调控全程胚系发育和衰老的造血干细胞自我更新与分化平衡
Masayuki Yamashita,Jingjing Li,Vu L Tran et al.
Masayuki Yamashita et al.
During fetal development, lifelong hematopoietic stem cells (HSCs) emerge from hemogenic endothelium as a part of the intra-arterial hematopoietic clusters. These definitive HSCs are deemed to colonize and expand in the fetal liver, migrate...
Peposertib suppresses generation of FLT3-internal tandem duplication formed by contralateral double nicks [0.03%]
Peposertib抑制由对侧双重切口形成的FLT3内部串联重复序列的生成
Shota Yoshida,Masahiro Onozawa,Shota Yokoyama et al.
Shota Yoshida et al.
FLT3-internal tandem duplication (ITD) is the most frequent gene mutation in acute myeloid leukemia. The consequences of FLT3-ITD have been analyzed in detail; however, the molecular mechanisms underlying FLT3-ITD generation have remained t...
Françoise Levavasseur,Samia Oussous,Alessandro Framarini et al.
Françoise Levavasseur et al.
Transcription factor forkhead box P1 (FOXP1) is a key regulator of immune cell functions. We have shown that FOXP1 contributes to the expansion of human hematopoietic stem/progenitor (HSPC) and acute myeloid leukaemia cells. Here, we invest...
Intra-bone marrow diversity of endothelial cells and its impact on hematopoietic stem cell development and maintenance [0.03%]
骨髓内内皮细胞的多样性及其对造血干细胞发育和维持的影响
Shota Shimizu,Yoshiaki Kubota
Shota Shimizu
In addition to supplying oxygen and nutrients, blood vessels secrete paracrine molecules known as angiocrine factors to promote tissue homeostasis and repair. The bone marrow (BM) vasculature in long bones has differing properties between t...
Transcription factors that define the epigenome structures and transcriptomes in microglia [0.03%]
定义小胶质细胞表观基因组结构和转录组的转录因子
Keita Saeki,Keiko Ozato
Keita Saeki
Microglia, the resident macrophages of the brain, play critical roles in maintaining brain health. Recent genome-wide analyses, including ATAC-seq, ChIP-seq/CUT&RUN, and single-cell RNA-seq, have identified key transcription factors that de...
Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis [0.03%]
Tet2突变克隆型血液病中髓样细胞偏移扩增的细胞外在因素影响
Aishwarya Krishnan,Linde A Miles,Grant A Challen
Aishwarya Krishnan
FAM210B Regulates Iron Homeostasis and Sex-Specific Responses in Stress Erythropoiesis [0.03%]
FAM210B调节铁稳态及应激促红细胞生成中的性别差异反应
Mark Perfetto,Muhammad Ishfaq,Aiden Mohideen et al.
Mark Perfetto et al.
Iron is required for redox homeostasis but poses toxicity risks due to its redox activity. Erythropoiesis hence requires tight regulation of iron utilization for hemoglobin synthesis. The requirement for iron in erythropoiesis has necessita...
Effect of peri-transplant measurable residual disease clearance in patients with myelodysplastic neoplasm; a referral center experience: Effect of peri-HSCT MRD Clearance in MDS [0.03%]
移植前残留病灶清除对骨髓衰竭性疾病患者的疗效：单中心经验报告
Kittika Poonsombudlert,Sarah Mott,Ratdanai Yodsuwan et al.
Kittika Poonsombudlert et al.
Peri-allogeneic stem cell transplant (peri-HSCT) measurable residual disease (MRD) is increasingly recognized as a prognostic marker. However, the MRD status in myelodysplastic neoplasm (MDS) or myelodysplastic/myeloproliferative neoplasm (...
Vesicle-Mediated Information Transfer in Cardiovascular Cell Differentiation [0.03%]
心血管细胞分化中的囊泡介导的信息传递
Jun K Yamashita
Jun K Yamashita
Extracellular vesicles (EVs)-including exosomes, microvesicles, and apoptotic bodies-are membrane-bound carriers of diverse molecular cargo such as nucleic acids, proteins, and lipids. They are increasingly recognized as critical mediators ...
Ontogeny, dynamics, and characteristics of neutrophils during the perinatal period [0.03%]
新生儿期中性粒细胞的发育、动态变化及特征
Ryo Ishiwata
Ryo Ishiwata
This review examines the dynamic development and unique characteristics of neutrophils during the perinatal period, a critical window when the immune system undergoes rapid reprogramming, based on the mouse studies. In the mouse fetal liver...