Wei Liang Gan,Leilei Chen
Wei Liang Gan
Blood cells exhibit a profound relationship with RNA editing, particularly adenosine deaminase acting on RNA 1 (ADAR1) dependent adenosine to inosine (A-to-I) RNA editing, impacting immune cell activity, haematological malignancy, and ultim...
Fetal Lymphocyte Progenitors Efficiently Generate Innate-Like B Cells but Make a More Limited Contribution to the Production of Conventional Lymphocytes [0.03%]
胎儿淋巴样祖细胞高效地生成天然样B细胞，但对常规淋巴细胞的产生的贡献有限
Encarnacion Montecino-Rodriguez,Kenneth Dorshkind
Encarnacion Montecino-Rodriguez
Various progenitor populations with lymphoid potential emerge in multiple waves of fetal development and can do so independent from hematopoietic stem cells (HSCs). This review compares and contrasts data from our analysis of a mutant mouse...
Impaired CMV-specific CD4+ T-cell reconstitution is associated with CMV infection after letermovir cessation [0.03%]
利托莫韦停药后巨细胞病毒感染与CMV特异性CD4+T细胞重建受损相关
Luxiang Wang,Su Li,Jiayu Huang et al.
Luxiang Wang et al.
Objectives: Cytomegalovirus (CMV) is a prevalent virus, which causes substantial morbidity and mortality in individuals undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although letermovir prophy...
Cis- and trans-regulation of Irf8 enhancers during dendritic cell development [0.03%]
转录因子IRF8在树突状细胞分化过程中的顺式和反式调控机制研究
Akira Nishiyama,Tomohiko Tamura
Akira Nishiyama
Dendritic cells (DCs) are mononuclear phagocytes that play a crucial role in the immune system by mediating innate and adaptive immunity. DC differentiation requires the establishment of DC-specific gene expression regulated by lineage-spec...
Alan Y Hsu,Qingxiang Huang,Fei Liu et al.
Alan Y Hsu et al.
Neutrophils play an indispensable role in the innate immune system as the body's first line of defense against pathogens. These highly specialized cells are rapidly recruited to infection sites, where they execute a variety of critical func...
Fetal heart as a new local site for hematopoiesis and macrophage formation [0.03%]
胎儿心脏作为新的造血和巨噬细胞生成部位
Norika Liu,Haruko Nakano,Atsushi Nakano
Norika Liu
Cardiac tissue macrophages are crucial components of the immune system and tissue homeostasis. Traditionally, these macrophages have been classified into three primary lineages: yolk sac blood island-derived erythromyeloid progenitor (EMP),...
Gene Regulatory Complexes: their role and regulation across normal and malignant haematopoiesis [0.03%]
基因调控复合体：它们在正常及恶性血液生成中的作用及其调控
Gina Sangha,Brian Jp Huntly
Gina Sangha
Transcription is regulated in a multitude of ways to ensure lineage- and context-specific gene expression in a co-ordinated fashion. Haematopoiesis is an exemplar process for studying the mechanisms of tightly regulated activation and repre...
Mer receptor expression promotes multiple myeloma disease development via a cell-extrinsic mechanism [0.03%]
髓系MERTK受体表达通过细胞非自主机制促进多发性骨髓瘤发病进展
Justine R Clark,Vasilios Panagopoulos,Jacqueline E Noll et al.
Justine R Clark et al.
Multiple myeloma (MM) is an incurable haematological malignancy characterised by the uncontrolled proliferation of bone marrow resident plasma cells (PCs). Two members of the TAM (TYRO3, AXL and MER) receptor family have previously been imp...
A new anchor point for gut microbiome to regulate complications of allogeneic hematopoietic stem cell transplantation: oxidative stress [0.03%]
肠道微生物组通过氧化应激调节异基因造血干细胞移植后并发症的新节点
Wenxuan Bai,Tiebin Jiang,Lanlan Tang et al.
Wenxuan Bai et al.
Teaser Abstract: Although there has been a large amount of reviews focusing on the relation between gut microbiome and the major complications after allogeneic hematopoietic stem-cell transplantation (allo-HSCT), few review have referred th...
Ao Zhang,Shaowei Qiu
Ao Zhang
Retinoic acid receptorα (RARα) is a ligand-dependent transcription factor that dimerizes with retinoid X receptor α (RXRα) to activate target gene promoters, playing a critical role in normal hematopoiesis and granulocyte differentiatio...