An engineered IgM antibody targeting CD20 has enhanced complement-dependent cytotoxicity compared to an IgG [0.03%]
一种工程化IgM抗体，与IgG相比，针对CD20具有增强的补体依赖性细胞毒性
Kevin C Hart,Paul R Hinton,Marigold Manlusoc et al.
Kevin C Hart et al.
Complement-dependent cytotoxicity (CDC) is one of the main mechanisms of action for approved therapeutic anti-CD20 IgG antibodies, including rituximab, ofatumumab and ocrelizumab, in the treatment of B cell lymphoma patients. However, resis...
Optimal ex vivo production of functional neutrophils is dependent on the source of CD34+ human hematopoietic progenitors [0.03%]
体外生成功能性中性粒细胞取决于人CD34+血液干细胞来源
Kyle D Timmer,Daniel J Floyd,Nathan E Jeffries et al.
Kyle D Timmer et al.
Neutrophils serve as the first line of defense against invasive bacterial and fungal pathogens. The loss of circulating neutrophils leaves patients at a critical risk of life-threatening infections. In this study, we optimized conditions fo...
Platelets loaded with alteplase exert fibrinolytic activity in human whole blood and plasma [0.03%]
载有阿替普酶的血小板在人全血和血浆中发挥溶栓作用
Masataka Inoue,Masahiro Ohwada,Teruhiko Negishi et al.
Masataka Inoue et al.
The utilization of alteplase for the management of intracerebral thromboembolism is associated with an elevated risk of intracerebral hemorrhage. To mitigate this risk, we investigated the fibrinolytic effect of alteplase-loaded platelets a...
Patricia Ernst,Perpetual Kyei,Akihiko Yokoyama
Patricia Ernst
Gene rearrangements of the human MLL gene (also known as KMT2A) generate multiple fusion oncoproteins which cause leukemia with poor prognosis. MLL is an epigenetic regulator that reads and writes epigenetic information and has an evolution...
Carl Walkley
Carl Walkley
Shaping the Future of Experimental Hematology - An Interview with Dr. Toshio Suda [0.03%]
实验血液学的未来——与Toshio Suda教授对话
Keisuke Ito
Keisuke Ito
This interview with Dr. Toshio Suda, Editor-in-Chief of Experimental Hematology (ISEH's official journal), previews the journal's future. New formats-Commentary, Society Voices, Editorial-and a revitalized Editorial Board aim to reflect vib...
Nobuyuki Takakura
Nobuyuki Takakura
The myeloid transcription factor Elf1 regulates genes with function in innate immunity [0.03%]
髓系转录因子Elf1调节天然免疫功能相关基因
Prabha Varghese,Maria-Paz Garcia-Cuellar,Robert K Slany
Prabha Varghese
Transcription factor networks are critical hubs for organ development. Here we investigated the hematopoietic function of the Ets-family transcription factor Elf1 that is normally predominantly expressed in monocytes. Strikingly, Elf1 was n...
ZC3H13 facilitates the progression of acute myeloid leukemia through m6A-FOXP1-mediated metabolic reprogramming [0.03%]
ZC3H13通过m6A-FOXP1介导的代谢重编程促进急性髓系白血病的发展
Jiaheng Wang,Linjuan Xu,Gang Wang et al.
Jiaheng Wang et al.
Acute myeloid leukemia (AML) is a complex hematological malignancy characterized by rapid progression and high relapse rates. Zinc finger CCCH domain-containing protein 13 (ZC3H13) has been implicated in the pathogenesis of various diseases...
Ali Hageb,Merieme Farjia,Collins Osei-Sarpong et al.
Ali Hageb et al.
Neutrophil development is a tightly regulated, multi-step process involving stem cell commitment, differentiation, and maturation in the bone marrow. Chromatin remodeling, transcriptional networks, epigenetic reprogramming, metabolic adapta...