Isabel M Forlastro,Norah L Smith,Emily N Kulp et al.
Isabel M Forlastro et al.
During the development of the immune system, there is a progressive shift from fast-acting innate-like lymphocytes to slower-acting adaptive lymphocytes. This developmental shift is evident in B cells, γδ T cells, and αβ T cells, with t...
Cohesin haploinsufficiency is tolerated in Cbfb::MYH11-driven murine acute myeloid leukemia [0.03%]
凝溶胶素单倍型不足可被携带Cbfb::MYH11驱动的急性髓系白血病的小鼠耐受
Shannon E Conneely,Alexis Quezada,Kristen J Kurtz et al.
Shannon E Conneely et al.
Cohesin gene mutations occur in many malignancies, including acute myeloid leukemia (AML). Loss-of-function mutations in the four major cohesin complex genes (RAD21, SMC3, SMC1a, STAG2) occur across most major genetic subtypes of AML but ar...
Louise E Purton
Louise E Purton
Mitochondrial Retention and Autophagy Dysregulation Drive Oxidative Stress in Sickle Cell Disease Erythrocytes [0.03%]
镰状细胞病红细胞中线粒体滞留和自噬失调驱动氧化应激反应
Jagadeesh Ramasamy,Prasanth Kumar Punathil Kannan,Sugasini Dhavamani et al.
Jagadeesh Ramasamy et al.
Sickle cell disease (SCD) is an inherited blood disorder caused by a mutation in the beta-globin gene, leading to hemoglobin polymerization under low oxygen conditions. This results in sickle-shaped red blood cells (Erythrocytes), hemolysis...
Asrij/OCIAD1 expression delineates functionally distinct hematopoietic stem cells in the bone marrow [0.03%]
ASRJ/OCIAD1表达界定了骨髓中功能不同的造血干细胞
Aishwarya Prakash,Souvik Halder,Maneesha S Inamdar
Aishwarya Prakash
Hematopoietic stem cells (HSCs) within the bone marrow (BM) display significant molecular and functional heterogeneity. Deciphering intrinsic factors that govern HSC diversity is key to enriching specific HSC subtypes for predictable and cl...
Leila Mahdavi,Fatemeh Alikarami,Haley Goodrow et al.
Leila Mahdavi et al.
Inhibitors of the Menin-KMT2A interaction are promising agents for the treatment of KMT2A-rearranged (KMT2A-r) leukemias. We evaluated Menin inhibition in patient derived xenografts of KMT2A-r leukemias with high-risk features. Three AMLs w...
Building a transparent and functional lab culture: Guidelines for creating a Laboratory Handbook for principal investigators [0.03%]
打造开放透明的功能性实验室文化——关于编写实验室指南的指导方针
Charles E de Bock,Katherine S Bridge,Nick van Gastel et al.
Charles E de Bock et al.
Akihiro Nakajima,Keisuke Kirito,Mio Nakanishi et al.
Akihiro Nakajima et al.
Hematopoietic stem cells (HSCs) possess unique characteristics that distinguish them from other hematopoietic progenitor cells, including self-renewal capacity, multipotency, stress response, metabolism, and deep quiescence. Recent advances...
A 30-gene classifier distinguishes low-risk MDS HSPCs from healthy HSPCs [0.03%]
一个包含30个基因的分类器能够区分低风险MDS造血干细胞和健康造血干细胞
Pawan Bhat,Joseph C Van Amburg,Chad R Potts et al.
Pawan Bhat et al.
Myelodysplastic syndromes (MDS) are a group of malignant clonal disorders that are characterized by functional impairment of hematopoiesis, morphologic dysplasia, and genetic heterogeneity1. While less likely to transform to acute leukemia,...
A xeno-free red blood cell differentiation formula models Sickle Cell Disease from somatically-sourced patient iPSCs [0.03%]
无异种红血细胞分化模型通过来源于体细胞的诱导多能干细胞模拟镰刀状细胞贫血病
Ashlee J Conway,Tolulope O Rosanwo,Thomas E Williamson et al.
Ashlee J Conway et al.
Human induced pluripotent stem cells (iPSCs) are an invaluable resource in both 2D and 3D tissue engineering due to their multi-lineage potential in culture systems. To date, modeling red blood cell (RBC) disorders such as Sickle Cell Disea...