Ever-evolving insights into the cellular and molecular drivers of lymphoid cell development [0.03%]
不断发展的关于淋巴细胞发育的细胞和分子驱动因素的见解
Vu L Tran,Myriam L R Haltalli,Jingjing Li et al.
Vu L Tran et al.
Lymphocytes play a critical role in adaptive immunity and defense mechanisms, but the molecular mechanisms by which hematopoietic stem and progenitor cells differentiate into T and B lymphocytes are not fully established. Pioneer studies id...
Splicing the Difference: Harnessing the Complexity of the Transcriptome in Hematopoiesis [0.03%]
巧妙拼接：利用转录组的复杂性促进血液生成
Hannah M Maul-Newby,Stephanie Halene
Hannah M Maul-Newby
Alternative splicing has long been recognized as a powerful tool to expand the diversity of the transcriptome and the proteome. The study of hematopoiesis, from hematopoietic stem cell maintenance and differentiation into committed progenit...
A new era of functional experimentation in human hematopoiesis and leukemia research [0.03%]
人类造血和白血病研究功能实验的新时代
Thomas Köhnke,Yang Feng,Ravindra Majeti
Thomas Köhnke
Functional experimentation has laid the foundation for our understanding of hematopoietic and leukemic stem cells. Yet, most recently, a flurry of descriptive studies of primary human cells, fueled by rapid technological advances in sequenc...
BST2 facilitates activation of hematopoietic stem cells through ERK signaling [0.03%]
BST2通过ERK信号转导促进造血干细胞的激活
Marcus A Florez,Apoorva Thatavarty,Duy T Le et al.
Marcus A Florez et al.
The proinflammatory cytokine interferon gamma (IFNγ) is upregulated in a variety of infections and contributes to bone marrow failure through hematopoietic stem cell (HSC) activation and subsequent exhaustion. The cell-surface protein, bon...
Cellular uptake of CPX-351 by scavenger receptor class B type 1-mediated nonendocytic pathway [0.03%]
CPX-351通过模式识别受体非内吞途径入胞
Hiroaki Araie,Naoko Hosono,Takahiro Yamauchi
Hiroaki Araie
The proper uptake of drugs in liposome formulations into target cells markedly impacts therapeutic efficacy. The protein corona (PC), formed by the adsorption of serum proteins onto the liposome surface, binds to specific surface receptors ...
Mame P Diop,Sjoukje J C van der Stegen
Mame P Diop
Adoptive cell therapy (ACT) enhances the patient's own immune cells' ability to identify and eliminate cancer cells. Several immune cell types are currently being applied in autologous ACT, including T cells, natural killer (NK) cells, and ...
Downregulation of autophagy is associated with poor clinical outcome after immunochemotherapy in patients with diffuse large B-cell lymphoma [0.03%]
自噬下调与弥漫性大B细胞淋巴瘤免疫化疗后的不良临床结局相关
Ya-Li Zhang,Meng-Xue Ma,Li-Na Xing et al.
Ya-Li Zhang et al.
This study aimed to determine the expression levels of the autophagy markers Beclin-1 and p62 in patients with diffuse large B-cell lymphoma (DLBCL) and explore the association between autophagy and disease prognosis. The expression of Becl...
Involvement of CREB3L1 in erythropoiesis induced by JAK2 exon 12 mutation [0.03%]
CREB3L1参与JAK2第12外显子突变诱导的红细胞生成
Maho Okuda,Marito Araki,Federico De Marchi et al.
Maho Okuda et al.
CREB3L1, a gene encoding the endoplasmic reticulum stress transducer, is specifically overexpressed in platelet RNA from patients with myeloproliferative neoplasms (MPNs). However, the pathophysiological roles of CREB3L1 overexpression rema...
Zhen Liang,Carl R Walkley,Jacki E Heraud-Farlow
Zhen Liang
Adenosine-to-inosine (A-to-I) RNA editing plays essential roles in modulating normal development and homeostasis. This process is catalyzed by adenosine deaminase acting on RNA (ADAR) family proteins. The most well-understood biological pro...
Kristina Kirschner
Kristina Kirschner