CD201 and CD27 identify hematopoietic stem and progenitor cells across multiple murine strains independently of Kit and Sca-1 [0.03%]
CD201 和 CD27 能够独立于Kit和Sca-1鉴定多个品系小鼠的造血干细胞及祖细胞
Sara E Vazquez,Matthew A Inlay,Thomas Serwold
Sara E Vazquez
Identification and isolation of hematopoietic stem cells (HSCs) in mice is most commonly based on the expression of surface molecules Kit and Sca-1 and the absence of markers of mature lineages. However, Sca-1 is absent or weakly expressed ...
Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells [0.03%]
ERK通过LKB1/AMPK信号通路负向调控人类急性髓系白血病细胞的功能研究
Ichiro Kawashima,Toru Mitsumori,Yumi Nozaki et al.
Ichiro Kawashima et al.
Adenosine monophosphate-activated protein kinase (AMPK) is a sensor for cellular energy status. When the cellular energy level is decreased, AMPK is activated and functions to suppress energy-consuming processes, including protein synthesis...
Ribosomal protein L11- and retinol dehydrogenase 11-induced erythroid proliferation without erythropoietin in UT-7/Epo erythroleukemic cells [0.03%]
Rib蛋白和视黄醇脱氢酶诱导UT-7/Epo红白血病细胞分化成熟替代途径的研究
Tanawan Kummalue,Tomoko Inoue,Yoshie Miura et al.
Tanawan Kummalue et al.
Erythropoiesis is the process of proliferation, differentiation, and maturation of erythroid cells. Understanding these steps will help to elucidate the basis of specific diseases associated with abnormal production of red blood cells. In t...
Digital PCR to assess hematopoietic chimerism after allogeneic stem cell transplantation [0.03%]
数字PCR技术在异基因造血干细胞移植后造血嵌合体评估中的应用
Tanja Stahl,Manja U Böhme,Nicolaus Kröger et al.
Tanja Stahl et al.
Analysis of hematopoietic chimerism after allogeneic stem cell transplantation represents a crucial method to evaluate donor-cell engraftment. Whereas sensitivity of classical approaches for chimerism monitoring is limited to ≥1%, quantita...
Monoclonal paraprotein influences baseline B-cell repertoire diversity and perturbates influenza vaccination-induced B-cell response [0.03%]
单克隆浆细胞影响基线B细胞谱系多样性和流感疫苗接种诱导的B细胞反应
Sarah M Tete,David Kipling,Johanna Westra et al.
Sarah M Tete et al.
Monoclonal gammopathy of undetermined significance (MGUS) arises from a clonal expansion of plasma cells in the bone marrow, secreting monoclonal (M) paraprotein. It is associated with increased susceptibility to infections, which may refle...
Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver [0.03%]
转铁蛋白受体1在红系造血细胞上的表达介导肝脏中的他汀素抑制作用的证据
Siobán B Keel,Raymond Doty,Li Liu et al.
Siobán B Keel et al.
Hepcidin is the key regulator of iron absorption and recycling, and its expression is suppressed by red blood cell production. When erythropoiesis is expanded, hepcidin expression decreases. To gain insight into the stage of erythroid diffe...
Romiplostim promotes platelet recovery in a mouse model of multicycle chemotherapy-induced thrombocytopenia [0.03%]
Romiplostim促进多周期化疗诱导的小鼠血小板减少模型的血小板恢复
Patricia L McElroy,Ping Wei,Keri Buck et al.
Patricia L McElroy et al.
Chemotherapy-induced thrombocytopenia can lead to chemotherapy treatment delays or dose reductions. The ability of romiplostim, a thrombopoietin (TPO) mimetic, to promote platelet recovery in a mouse model of multicycle chemotherapy/radiati...
Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators [0.03%]
克拉屈滨与克罗拉滨联合氟达拉滨和布沙林在急性髓系白血病细胞中的细胞毒性比较及表观遗传学调控药物增强其细胞毒性的研究
Benigno C Valdez,Yang Li,David Murray et al.
Benigno C Valdez et al.
Clofarabine (Clo), fludarabine (Flu), and busulfan (Bu) combinations are efficacious in hematopoietic stem cell transplantation for myeloid leukemia. We sought to determine whether the more affordable drug cladribine (Clad) can provide a vi...
Comparative Study
Experimental hematology. 2015 Jun;43(6):448-61.e2. DOI:10.1016/j.exphem.2015.02.001 2015
Acute GVHD after allogeneic hematopoietic transplantation affects early marrow reconstitution and speed of engraftment [0.03%]
异基因造血干细胞移植后急性移植物抗宿主病影响早期骨髓重建及植入速度
Giuseppe Milone,Maria Grazia Camuglia,Giuseppe Avola et al.
Giuseppe Milone et al.
Our aim was to study the influence of acute graft-versus-host disease (a-GVHD) on primary engraftment times after allogeneic transplantation. Primary engraftment and frequency of marrow granulocyte-macrophage colony-forming units and erythr...
Deep sequencing and proteomic analysis of the microRNA-induced silencing complex in human red blood cells [0.03%]
人红细胞中microRNA诱导的沉默复合物的深度测序和蛋白质组分析
Imane Azzouzi,Hansjoerg Moest,Bernd Wollscheid et al.
Imane Azzouzi et al.
During maturation, erythropoietic cells extrude their nuclei but retain their ability to respond to oxidant stress by tightly regulating protein translation. Several studies have reported microRNA-mediated regulation of translation during t...