CBX7 inhibitors affect H3K9 methyltransferase-regulated gene repression in leukemic cells [0.03%]
CBX7抑制剂影响白血病细胞中H3K9甲基转移酶介导的基因沉默作用
Anne P de Groot,Huong Nguyen,Jacobine S Pouw et al.
Anne P de Groot et al.
The epigenome of leukemic cells is dysregulated, and genes required for cell cycle arrest and differentiation may become repressed, which contributes to the accumulation of undifferentiated malignant blood cells. Here, we show that the Poly...
Novel techniques to quantitatively assess age-dependent alterations in biophysical properties of HSPCs and bone marrow niche [0.03%]
新型定量评估HSPC和骨髓生态位的年龄相关性生物物理属性变化的方法
Anthony D Ho,Motomu Tanaka
Anthony D Ho
The present knowledge on hematopoietic stem and progenitor cell (HSPC) biology and aging is based largely on studies in mouse models. Although mouse models are invaluable, they are not without limitations for defining how physical propertie...
Alban Johansson,Nicole Pui-Yu Ho,Hitoshi Takizawa
Alban Johansson
The microbiome is a highly complex and diverse symbiotic component that undergoes dynamic changes with the organismal aging. Microbial perturbations, termed dysbiosis, exert strong influence on dysregulating the bone marrow niche and subseq...
Differential impact of CD34+ cell dose for different age groups in allogeneic hematopoietic cell transplantation for acute leukemia: a machine learning-based discovery [0.03%]
基于机器学习的同种异体造血细胞移植治疗急性白血病的不同年龄组CD34+细胞剂量的不同影响发现
Yiyang Qu,Hamed Shourabizadeh,Aravind Subramanian et al.
Yiyang Qu et al.
Allogeneic hematopoietic cell transplantation (allo-HCT) presents a potentially curative treatment for hematologic malignancies yet carries associated risks and complications. Continuous research focuses on predicting outcomes and identifyi...
Advice for effective leadership and hitting the ground running as a new group leader [0.03%]
新任组长如何快速上手及有效领导的建议
Lev M Kats,Charles E de Bock
Lev M Kats
FT-4202, a selective pyruvate kinase R activator for sickle cell disease [0.03%]
傅氏-4202：一种选择性的丙酮酸激酶R激活剂，用于镰状细胞病治疗
Anna Ericsson,David J Richard,Erik Wilker et al.
Anna Ericsson et al.
Anemia in patients with sickle cell disease (SCD) increases 2,3-diphosphoglycerate (2,3-DPG), decreasing hemoglobin-oxygen (HbO2) affinity to improve oxygen offloading and promote hemoglobin polymerization (sickling) of red blood cells (RBC...
Structural diversity and function of the granulocyte colony-stimulating factor in medaka fish [0.03%]
斑马鱼粒细胞集落刺激因子的结构多样性及功能研究
Ayame Ogawa,Shungo Konno,Satoshi Ansai et al.
Ayame Ogawa et al.
Diversity in the granulocyte repertoire, including neutrophils, basophils, and eosinophils, has been reported in vertebrate species. Medaka fish (Oryzias latipes) have only neutrophils; however, the storage pool of granulopoiesis tissues an...
Platelet ultrastructural changes stored at room temperature versus cold storage observed by electron microscopy and structured illumination microscopy [0.03%]
室温与低温保存血小板的结构变化观察——电子显微镜和结构照明荧光显微镜观测结果比较
Yang Sun,Shunli Gu,Yan Ma et al.
Yang Sun et al.
Our study seeks to provide a theoretical foundation for the clinical use of cold-stored platelets (CSPs) by interpreting ultrastructural images and quantitatively analyzing structural changes. CSPs, room temperature-stored platelets (RTPs),...
Efficacy and safety of avatrombopag in combination with standard immunosuppressive therapy for severe aplastic anemia [0.03%]
阿伐曲波帕联合常规免疫抑制治疗重型再生障碍性贫血的疗效和安全性
Jianping Li,Weiru Liang,Huihui Fan et al.
Jianping Li et al.
Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disease. The addition of eltrombopag to immunosuppressive therapy (IST) improves the response rate, but its hepatotoxicity is concerning. Avatrombopag (AVA), a small-mol...
Inducible pluripotent stem cell models to study bone marrow failure and MDS predisposition syndromes [0.03%]
诱导性多能干细胞模型在骨髓功能衰竭和MDS易感综合征研究中的应用
Sushree S Sahoo,Majd Khiami,Marcin W Wlodarski
Sushree S Sahoo
Induced pluripotent stem cells (iPSCs) have emerged as powerful tools for in vitro modeling of bone marrow failure (BMF) syndromes and hereditary conditions predisposing to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Th...