Ernesto Scibona,Massimo Morbidelli
Ernesto Scibona
Living cells are emerging as therapeutic entities for the treatment of patients affected with severe and chronic diseases where no conventional drug can provide a definitive cure. At the same time, the promise of cell-based therapies comes ...
Aswathi Ashok,Deepak Choudhury,Yu Fang et al.
Aswathi Ashok et al.
Organoids are 3D miniature versions of organs produced from stem cells derived from either patient or healthy individuals in vitro that recapitulate the actual organ. Organoid technology has ensured an alternative to pre-clinical drug testi...
Combination of bioelectrochemical systems and electrochemical capacitors: Principles, analysis and opportunities [0.03%]
生物电化学系统与电化学电容器的结合：原理、分析和机遇
Leire Caizán-Juanarena,Casper Borsje,Tom Sleutels et al.
Leire Caizán-Juanarena et al.
Bioelectrochemical systems combine electrodes and reactions driven by microorganisms for many different applications. The conversion of organic material in wastewater into electricity occurs in microbial fuel cells (MFCs). The power densiti...
Starch-binding domains as CBM families-history, occurrence, structure, function and evolution [0.03%]
淀粉结合域作为CBM族类的历史、出现、结构、功能和进化
Štefan Janeček,Filip Mareček,E Ann MacGregor et al.
Štefan Janeček et al.
The term "starch-binding domain" (SBD) has been applied to a domain within an amylolytic enzyme that gave the enzyme the ability to bind onto raw, i.e. thermally untreated, granular starch. An SBD is a special case of a carbohydrate-binding...
Application of next-generation sequencing for the identification of herbal products [0.03%]
下一代测序技术在草药鉴别中的应用研究
Yat Tung Lo,Pang Chui Shaw
Yat Tung Lo
Conventional Sanger Sequencing for authentication of herbal products is difficult since they are mixture of herbs with fragmented DNA. Next-generation sequencing (NGS) techniques give massive parallelization of sequencing reaction to genera...
Nonribosomal peptides in fungal cell factories: from genome mining to optimized heterologous production [0.03%]
非核糖体肽在真菌细胞工厂中的研究：从基因组挖掘到优化异源生产
Antoine Vassaux,Loïc Meunier,Micheline Vandenbol et al.
Antoine Vassaux et al.
Fungi are notoriously prolific producers of secondary metabolites including nonribosomal peptides (NRPs). The structural complexity of NRPs grants them interesting activities such as antibiotic, anti-cancer, and anti-inflammatory properties...
CRISPR technologies for stem cell engineering and regenerative medicine [0.03%]
用于干细胞工程和再生医学的CRISPR技术
Mu-Nung Hsu,Yu-Han Chang,Vu Anh Truong et al.
Mu-Nung Hsu et al.
CRISPR/Cas9 system exploits the concerted action of Cas9 nuclease and programmable single guide RNA (sgRNA), and has been widely used for genome editing. The Cas9 nuclease activity can be abolished by mutation to yield the catalytically dea...
Ronan R McCarthy,Muhammad Wajid Ullah,Peter Booth et al.
Ronan R McCarthy et al.
Additive manufacturing or 3D printing has spearheaded a revolution in the biomedical sector allowing the rapid prototyping of medical devices. The recent advancements in bioprinting technology are enabling the development of potential new t...
Rebecca P Chen,Andrew S Gaynor,Wilfred Chen
Rebecca P Chen
Protein degradation is an effective native mechanism used in modulating intracellular information, and thus it plays an essential role in maintaining cellular homeostasis. Repurposing native protein degradation in a synthetic context is gai...
Inverse pharmacology: Approaches and tools for introducing druggability into engineered proteins [0.03%]
逆向药理学：工程化蛋白质引入可成药性的方法和工具
Jamie A Davies,Sam Ireland,Simon Harding et al.
Jamie A Davies et al.
A major feature of twenty-first century medical research is the development of therapeutic strategies that use 'biologics' (large molecules, usually engineered proteins) and living cells instead of, or as well as, the small molecules that w...