Kuili Fang,Oh-Jin Park,Seok Hoon Hong
Kuili Fang
Bacterial biofilms are formed by the complex but ordered regulation of intra- or inter-cellular communication, environmentally responsive gene expression, and secretion of extracellular polymeric substances. Given the robust nature of biofi...
Mapping and refactoring pathway control through metabolic and protein engineering: The hexosamine biosynthesis pathway [0.03%]
通过代谢和蛋白质工程绘制和重构途径控制：己糖胺生物合成途径
Pieter Coussement,David Bauwens,Gert Peters et al.
Pieter Coussement et al.
Microorganisms possess a plethora of regulatory mechanisms to tightly control the flux through their metabolic network, allowing optimal behaviour in response to environmental conditions. However, these mechanisms typically counteract metab...
Expanding the chemical diversity through microorganisms co-culture: Current status and outlook [0.03%]
通过共生微生物扩大化学多样性：现状与展望
Divya Arora,Prasoon Gupta,Sundeep Jaglan et al.
Divya Arora et al.
Natural products (NPs) are considered as a cornerstone for the generation of bioactive leads in drug discovery programs. However, one of the major limitations of NP drug discovery program is "rediscovery" of known compounds, thereby hinderi...
Cyanobacterial sigma factors: Current and future applications for biotechnological advances [0.03%]
蓝藻sigma因子的结构与功能及其在生物技术中的应用展望
Amit Srivastava,Michael L Summers,Roman Sobotka
Amit Srivastava
A sigma (σ) factor is a constituent of bacterial RNA polymerase that guides the holoenzyme to promoter sequences and initiates transcription. In addition to a primary housekeeping σ factor, bacteria contain a number of alternative σ fact...
Whole-cell biocatalysis using cytochrome P450 monooxygenases for biotransformation of sustainable bioresources (fatty acids, fatty alkanes, and aromatic amino acids) [0.03%]
利用细胞色素P450单加氧酶进行全细胞生物催化，将可持续生物资源（脂肪酸、脂肪烷烃和芳香族氨基酸）进行生物转化
HyunA Park,Gyuyeon Park,Wooyoung Jeon et al.
HyunA Park et al.
Cytochrome P450s (CYPs) are heme-thiolated enzymes that catalyze the oxidation of CH bonds in a regio and stereoselective manner. Activation of the non-activated carbon atom can be further enhanced by multistep chemo-enzymatic reactions; mo...
Molecular priming as an approach to induce tolerance against abiotic and oxidative stresses in crop plants [0.03%]
分子预适应诱导作物植物非生物和氧化逆境胁迫抗性的研究进展
Pavel Kerchev,Tom van der Meer,Neerakkal Sujeeth et al.
Pavel Kerchev et al.
Abiotic stresses, including drought, salinity, extreme temperature, and pollutants, are the main cause of crop losses worldwide. Novel climate-adapted crops and stress tolerance-enhancing compounds are increasingly needed to counteract the ...
Cui-Cui Ma,Zhen-Ling Wang,Ting Xu et al.
Cui-Cui Ma et al.
With the improvement of gene vectors, the rise of chimeric antigen receptor T cell immunotherapy and breakthroughs in the genome editing technology, gene therapy had once again returned to the central stage of disease treatment. It had brou...
Fungal potential for the degradation of petroleum-based polymers: An overview of macro- and microplastics biodegradation [0.03%]
真菌降解石油基聚合物的潜力：宏观和微观塑料生物降解综述
Carmen Sánchez
Carmen Sánchez
Petroleum-based plastic materials as pollutants raise concerns because of their impact on the global ecosystem and on animal and human health. There is an urgent need to remove plastic waste from the environment to overcome the environmenta...
Towards a new avenue for producing therapeutic proteins: Microalgae as a tempting green biofactory [0.03%]
生产治疗蛋白的新途径——微藻作为诱人的绿色生物工厂
Jaber Dehghani,Khosro Adibkia,Ali Movafeghi et al.
Jaber Dehghani et al.
Most of the recent approved therapeutic proteins are multi-subunit biologics, which need glycosylation and disulfide bridges for their correct conformation and biological functions. Currently, there exist many protein-based drugs that are m...
Xiujuan Qian,Lin Chen,Yuan Sui et al.
Xiujuan Qian et al.
Recent advances in microbial consortia present a valuable approach for expanding the scope of metabolic engineering. Systems biology enable thorough understanding of diverse physiological processes of cells and their interactions, which in ...