Applications of small molecules in modulating productivity and product quality of recombinant proteins produced using cell cultures [0.03%]
小分子调节细胞培养体系中重组蛋白产量和质量的应用研究进展
Ping Xu,Sen Xu,Chunyan He et al.
Ping Xu et al.
Mammalian cell cultures have been used extensively for production of recombinant protein therapeutics such as monoclonal antibodies, fusion proteins and enzymes for decades. Small molecules have been investigated as media supplements to imp...
Binod Prasad,Peter Richter,Nithya Vadakedath et al.
Binod Prasad et al.
Living organisms adapt to changing environments using their amazing flexibility to remodel themselves by a process called evolution. Environmental stress causes selective pressure and is associated with genetic and phenotypic shifts for bet...
Shadi Rahimi,Oskar Modin,Ivan Mijakovic
Shadi Rahimi
Water contamination is a growing environmental issue. Several harmful effects on human health and the environment are attributed to nitrogen contamination of water sources. Consequently, many countries have strict regulations on nitrogen co...
Biotransformation of dietary phytoestrogens by gut microbes: A review on bidirectional interaction between phytoestrogen metabolism and gut microbiota [0.03%]
膳食植物雌激素的肠道微生物转化：植物雌激素代谢与肠道菌群相互作用的研究进展综述
Ahkam Saddam Seyed Hameed,Parkash Singh Rawat,Xiangfeng Meng et al.
Ahkam Saddam Seyed Hameed et al.
Phytoestrogens are a class of plant produced polyphenolic compounds with diphenolic structure, which is similar to 17β-estradiol. These phytoestrogens preferentially bind to estrogen receptors, however, with weak affinity. Recently, many s...
Coenzyme A thioester-mediated carbon chain elongation as a paintbrush to draw colorful chemical compounds [0.03%]
以泛酰巯基乙胺硫酯介导的碳链延长反应为画笔绘制五彩斑斓的含硫天然药物化学世界
Shenghu Zhou,Tingting Hao,Shumin Xu et al.
Shenghu Zhou et al.
The biosynthesis of various useful chemicals from simple substrates using industrial microorganisms is becoming increasingly crucial to address the challenge of dwindling non-renewable resources. As the most common intermediate substrates i...
Protein folding and assembly in confined environments: Implications for protein aggregation in hydrogels and tissues [0.03%]
限制性环境中的蛋白质折叠和装配：水凝胶和组织中蛋白质聚集的启示
Laura W Simpson,Theresa A Good,Jennie B Leach
Laura W Simpson
In the biological milieu of a cell, soluble crowding molecules and rigid confined environments strongly influence whether the protein is properly folded, intrinsically disordered proteins assemble into distinct phases, or a denatured or agg...
Amidase as a versatile tool in amide-bond cleavage: From molecular features to biotechnological applications [0.03%]
氨肽酶在酰胺键断裂中的多功能工具性：从分子特征到生物技术应用
Zheming Wu,Changfeng Liu,Zhaoyu Zhang et al.
Zheming Wu et al.
Amidases (EC 3. 5. 1. X) are versatile biocatalysts for synthesis of chiral carboxylic acids, α-amino acids and amides due to their hydrolytic and acyl transfer activity towards the C-N linkages. They have been extensively exploited and st...
Sukanya Bhowmick,Aninda Mazumdar,Amitava Moulick et al.
Sukanya Bhowmick et al.
Antibiotic resistance is rising at a pace that is difficult to cope with; circumvention of this issue requires fast and efficient alternatives to conventional antibiotics. Algae inhabit a wide span of ecosystems, which contributes to their ...
Purple phototrophic bacteria for resource recovery: Challenges and opportunities [0.03%]
紫光合细菌在资源回收中的挑战与机遇
Gabriel Capson-Tojo,Damien J Batstone,María Grassino et al.
Gabriel Capson-Tojo et al.
Sustainable development is driving a rapid focus shift in the wastewater and organic waste treatment sectors, from a "removal and disposal" approach towards the recovery and reuse of water, energy and materials (e.g. carbon or nutrients). P...
Downstream processing technologies in the biocatalytic production of oligosaccharides [0.03%]
生物催化寡糖生产的下游加工技术
Andreas Kruschitz,Bernd Nidetzky
Andreas Kruschitz
Oligosaccharides are important ingredients for food and feed products. There has therefore been much interest in the development of biocatalytic processes for their production. Irrespective of the oligosaccharide manufacturing route, that i...