The advances of strategies and technologies in high-throughput microbial culturomics [0.03%]
高通量微生物培养组学策略及技术进展
Zheng-Hui Li,Shuang Li,Hai-Bo Chen et al.
Zheng-Hui Li et al.
The growing demand for novel antibiotics, industrial enzymes, and environmentally sustainable biotechnological solutions is drawing increasing attention to more efficient strategies for microbial resource discovery across biomedical, indust...
Synthetic biology strategies for engineering probiotics and commensal bacteria for diagnostics and therapeutics [0.03%]
合成生物学策略：用于诊断和治疗的益生菌和共生菌工程化
Jiwoo Nam,Yuna Lee,Sion Lee et al.
Jiwoo Nam et al.
Microorganisms inhabit diverse environments, including nearly every organ in the human body. The human microbiome-a complex community of microorganisms residing in the human body-has gained increasing attention as a key contributor to human...
Designing prokaryotic gene expression regulatory elements: From genomic mining to artificial intelligence-driven generation [0.03%]
从基因组挖掘到人工智能驱动设计：原核生物基因表达调控元件的人工设计
Xuan Zhou,Wenyan Cao,Chao Huang et al.
Xuan Zhou et al.
Gene expression regulatory elements (GEREs) play a pivotal role in the control of gene transcription and translation. The design of GEREs with precise and tunable activity remains a major challenge in synthetic biology. Over the past decade...
Flavin reductases in two-component systems: Mechanistic insights, structural classification, and biotechnological advances [0.03%]
flavin 还原酶的二元系统：机制见解、结构分类和生物技术进展
Panu Pimviriyakul,Piyanuch Anuwan,Pimchai Chaiyen et al.
Panu Pimviriyakul et al.
Flavin reductases (FRs) are essential redox enzymes that supply reduced flavin cofactors (FMNH-/FADH-) to various monooxygenase partners in two-component flavin-dependent monooxygenase (TC-FDMO) systems. These enzymes play critical roles in...
The key role that cellulose accessibility plays in restricting enzyme-mediated hydrolysis of cellulose [0.03%]
纤维素可及性在限制酶促水解纤维素过程中的关键作用
Jie Wu,Tianjie Ao,Yufeng Yuan et al.
Jie Wu et al.
Although cellulose can be found in nature in an unassociated form (e.g., cotton, microbially derived cellulose, etc.), it is typically associated with other polymers such as lignin and hemicellulose. However, even "pure" cellulose has prove...
Physiological response of solventogenic clostridia to lignocellulose-derived inhibitors [0.03%]
溶剂生成性芽孢杆菌对木质纤维素衍生抑制剂的生理反应
Kamila Koppova,Barbora Branska
Kamila Koppova
Lignocellulose represents a sustainable feedstock for the production of platform chemicals, yet its potential is influenced by inhibitory compounds that impair microbial performance. Among microbial producers, solventogenic Clostridium spec...
Droplet microfluidics for single-cell analysis: From improved cell encapsulation and sorting technologies to innovative applications [0.03%]
用于单细胞分析的微滴微流控技术：从改进的细胞包裹和分拣技术到创新应用
Shuman Song,Jiaran Lu,Xiangyun Jiang et al.
Shuman Song et al.
Single-cell analysis affords a novel perspective for deciphering the intricacies of complex biological systems by elucidating the subtle heterogeneities within cellular populations, with particular relevance to cellular development, pathoph...
Andrea M Garza Elizondo,Ilenne Del Valle Kessra,Erica Teixeira Prates et al.
Andrea M Garza Elizondo et al.
The field of synthetic biology is essential to the continued development of a bio-based economy, creating mechanisms to supply carbon needed in the economy by both converting existing end-of-life wastes as well as by creating novel, purpose...
Jiayun Fu,Xiaoqian Tang,Du Wang et al.
Jiayun Fu et al.
Nanobodies (Nbs), the single-domain antigen-binding fragments, have emerged as promising biorecognition elements for immunoassays due to their small size, high stability, strong affinity, and ease of engineering. This review comprehensively...
Plasticity and adaptive architecture of roots for enhanced salinity tolerance in crops [0.03%]
提高作物耐盐性的根系塑性和适应性结构
Faheem Tariq,Linmao Zhao,Saddam Hussain et al.
Faheem Tariq et al.
Soil salinization poses a major challenge to global food security, affecting over one billion hectares of arable land and severely constraining crop productivity. As the primary interface between plants and soil, roots play a pivotal role i...