A review on squalene production by engineered yeasts: Current advances and perspectives [0.03%]
工程酵母角鲨烯生产研究进展与展望
Peng-Cheng Hu,La-Mei Ding,Qiao-Qin Zhao et al.
Peng-Cheng Hu et al.
Squalene, as a natural triterpenoid exhibiting various physiological activities, is primarily extracted from shark liver oil. However, due to the declining shark populations and conservation concerns, the alternative methods for squalene pr...
Integrating multi-omics and artificial intelligence fuels advanced target identification and drug discovery [0.03%]
多组学与人工智能融合推动靶点发现和药物发现创新发展
Hang Chen,Ying Shi,Meiling Yuan et al.
Hang Chen et al.
Target identification is pivotal for developing novel therapeutics in cancer and other diseases. Traditional experiment screening methods are constrained by low throughput and the complexity of biological systems. Multi-omics technologies o...
Morphological regulation of filamentous fungi improves industrial production [0.03%]
丝状真菌形态调控改善工业发酵性能
Qinghua Li,Chen Zhang,Jingwen Zhou et al.
Qinghua Li et al.
Filamentous fungi have emerged as ideal chassis cells for high-value products such as industrial enzymes, therapeutic proteins, and antibiotics, due to their broad substrate adaptability, efficient protein secretion capacity, and well-devel...
Enzyme symphony in bio-inspired multi-enzyme cascades for enhanced biosynthesis [0.03%]
受生物启发的多酶级联反应中的酶合奏在增强生物合成中的作用
Huan Liu,Lunjie Wu,Songyin Zhao et al.
Huan Liu et al.
Artificial multi-enzyme cascades utilize enzymatic catalysis to achieve continuous complex biosynthesis, thus, standing out as a promising approach. The remarkable efficiency of cascade reactions arises from the precise coordination among m...
Geometric deep learning assists protein engineering. Opportunities and Challenges [0.03%]
几何深度学习助力蛋白质工程——机遇与挑战
Julián García-Vinuesa,Jorge Rojas,Nicole Soto-García et al.
Julián García-Vinuesa et al.
Protein engineering is experiencing a paradigmatic transformation through the integration of geometric deep learning (GDL) into computational design workflows. While traditional approaches such as rational design and directed evolution have...
Spatial transcriptomics: integrating platforms and computational approaches for clinical insights [0.03%]
空间转录组学：整合平台和计算方法以获得临床见解
Wei Song,Duo Wang,Jinming Li et al.
Wei Song et al.
Spatial transcriptomics (ST) is a significant advancement in life science research, enabling transcriptome analysis to transition from traditional bulk and single-cell levels to spatial location levels, thereby expanding the boundaries of b...
Viral clearance in biopharmaceutical manufacturing: Current strategies, challenges, and future directions [0.03%]
生物制药生产中的病毒清除：当前策略、挑战及未来方向
Dhruvkumar Hariharbhai Soni,V Reghellin,G Sbarufatti et al.
Dhruvkumar Hariharbhai Soni et al.
Viral safety remains a fundamental requirement in the manufacturing of monoclonal antibodies (mAbs), particularly due to the widespread use of mammalian cell lines susceptible to both endogenous and adventitious viral contamination. This re...
From traditional to AI-driven: The evolution of intelligent enzyme engineering for biocatalysis [0.03%]
从传统到AI驱动的智能酶工程的生物催化发展之路
Feifei Lv,Jiaxing Zhang,Shengping You et al.
Feifei Lv et al.
Enzyme engineering involves enhancing enzyme function and application through multidimensional technological systems. Its development encompasses elucidating sequence-structure-function relationships, exploring fitness landscapes, and multi...
Bhawna Verma,Palak Arora,Shahnawaz Hussain et al.
Bhawna Verma et al.
Uridine Diphosphate glycosyltransferases (UGTs) catalyze the transfer of glycosyl moieties from donors to acceptors, a modification critical for plant growth, development, and metabolic homeostasis. These enzymes are ubiquitous across all l...
Submission to Biotechnology Advances Main Manuscript entitled: Perspective: "Membranes: The only chance for the mRNA tortoise to win, economically" [0.03%]
题为：“膜：mRNA疗法经济竞争制胜的唯一机会”的稿件提交给《生物技术进展》期刊
Thomas G Neuman,Surya Karla,James Chip Kilduff et al.
Thomas G Neuman et al.
The RNA revolution, advancing beyond traditional vaccines to new therapeutic modalities and constructs such as self-amplifying RNA (saRNA) and circular RNA (circRNA), continues to place increasing pressure on downstream purification. Diffus...