Enzyme symphony in bio-inspired multi-enzyme cascades for enhanced biosynthesis [0.03%]
受生物启发的多酶级联反应中的酶合奏在增强生物合成中的作用
Huan Liu,Lunjie Wu,Songyin Zhao et al.
Huan Liu et al.
Artificial multi-enzyme cascades utilize enzymatic catalysis to achieve continuous complex biosynthesis, thus, standing out as a promising approach. The remarkable efficiency of cascade reactions arises from the precise coordination among m...
Geometric deep learning assists protein engineering. Opportunities and Challenges [0.03%]
几何深度学习助力蛋白质工程——机遇与挑战
Julián García-Vinuesa,Jorge Rojas,Nicole Soto-García et al.
Julián García-Vinuesa et al.
Protein engineering is experiencing a paradigmatic transformation through the integration of geometric deep learning (GDL) into computational design workflows. While traditional approaches such as rational design and directed evolution have...
Spatial transcriptomics: integrating platforms and computational approaches for clinical insights [0.03%]
空间转录组学：整合平台和计算方法以获得临床见解
Wei Song,Duo Wang,Jinming Li et al.
Wei Song et al.
Spatial transcriptomics (ST) is a significant advancement in life science research, enabling transcriptome analysis to transition from traditional bulk and single-cell levels to spatial location levels, thereby expanding the boundaries of b...
Viral clearance in biopharmaceutical manufacturing: Current strategies, challenges, and future directions [0.03%]
生物制药生产中的病毒清除：当前策略、挑战及未来方向
Dhruvkumar Hariharbhai Soni,V Reghellin,G Sbarufatti et al.
Dhruvkumar Hariharbhai Soni et al.
Viral safety remains a fundamental requirement in the manufacturing of monoclonal antibodies (mAbs), particularly due to the widespread use of mammalian cell lines susceptible to both endogenous and adventitious viral contamination. This re...
From traditional to AI-driven: The evolution of intelligent enzyme engineering for biocatalysis [0.03%]
从传统到AI驱动的智能酶工程的生物催化发展之路
Feifei Lv,Jiaxing Zhang,Shengping You et al.
Feifei Lv et al.
Enzyme engineering involves enhancing enzyme function and application through multidimensional technological systems. Its development encompasses elucidating sequence-structure-function relationships, exploring fitness landscapes, and multi...
Bhawna Verma,Palak Arora,Shahnawaz Hussain et al.
Bhawna Verma et al.
Uridine Diphosphate glycosyltransferases (UGTs) catalyze the transfer of glycosyl moieties from donors to acceptors, a modification critical for plant growth, development, and metabolic homeostasis. These enzymes are ubiquitous across all l...
Submission to Biotechnology Advances Main Manuscript entitled: Perspective: "Membranes: The only chance for the mRNA tortoise to win, economically" [0.03%]
题为：“膜：mRNA疗法经济竞争制胜的唯一机会”的稿件提交给《生物技术进展》期刊
Thomas G Neuman,Surya Karla,James Chip Kilduff et al.
Thomas G Neuman et al.
The RNA revolution, advancing beyond traditional vaccines to new therapeutic modalities and constructs such as self-amplifying RNA (saRNA) and circular RNA (circRNA), continues to place increasing pressure on downstream purification. Diffus...
The advances of strategies and technologies in high-throughput microbial culturomics [0.03%]
高通量微生物培养组学策略及技术进展
Zheng-Hui Li,Shuang Li,Hai-Bo Chen et al.
Zheng-Hui Li et al.
The growing demand for novel antibiotics, industrial enzymes, and environmentally sustainable biotechnological solutions is drawing increasing attention to more efficient strategies for microbial resource discovery across biomedical, indust...
Synthetic biology strategies for engineering probiotics and commensal bacteria for diagnostics and therapeutics [0.03%]
合成生物学策略：用于诊断和治疗的益生菌和共生菌工程化
Jiwoo Nam,Yuna Lee,Sion Lee et al.
Jiwoo Nam et al.
Microorganisms inhabit diverse environments, including nearly every organ in the human body. The human microbiome-a complex community of microorganisms residing in the human body-has gained increasing attention as a key contributor to human...
Designing prokaryotic gene expression regulatory elements: From genomic mining to artificial intelligence-driven generation [0.03%]
从基因组挖掘到人工智能驱动设计：原核生物基因表达调控元件的人工设计
Xuan Zhou,Wenyan Cao,Chao Huang et al.
Xuan Zhou et al.
Gene expression regulatory elements (GEREs) play a pivotal role in the control of gene transcription and translation. The design of GEREs with precise and tunable activity remains a major challenge in synthetic biology. Over the past decade...