Aptamer screening within sample matrices: Toward reliable applications [0.03%]
直接在样本基质中筛选 aptamer：面向可靠应用
Chao Zhu,Yichun Zhang,Yunxiang Li et al.
Chao Zhu et al.
Nucleic acid aptamers are short oligonucleotide sequences selected in vitro by Systematic Evolution of Ligands by EXponential enrichment (SELEX). As "chemical antibodies", they recognize diverse targets with high affinity and specificity th...
Microbe-specific and product-specific strategies for scalable biomanufacturing [0.03%]
针对微生物和产物的生物制造扩展策略
Shi&#x;&#x;an Wang,Zhengjun Li,Peng Hu et al.
Shi&#x;&#x;an Wang et al.
The translation of microbial biotechnology from laboratory research to commercial application remains a persistent challenge, despite decades of effort. A key yet often neglected issue is the misalignment between microbial host selection, p...
Promoter engineering in oleaginous yeasts for value-added chemical production [0.03%]
利用产油酵母进行 promoーター 定制以生产高附加值化学品
Akhmad Awaludin Agustiar,Zewei Lu,Dianqi Yang et al.
Akhmad Awaludin Agustiar et al.
Oleaginous yeasts, particularly Yarrowia lipolytica, are increasingly used as microbial platforms for producing lipids and other value-added compounds from renewable feedstocks. Their biotechnological utility derives from active lipid metab...
Strategies for biofilm disruption: Mechanisms, polymeric networks, mixed infections, and emerging biomaterials [0.03%]
菌膜干扰策略：作用机制、聚合网络、混合感染及新兴生物材料
John H T Luong,Aharon Gedanken
John H T Luong
Biofilms represent the predominant microbial lifestyle in clinical and environmental settings, where the extracellular polymeric substance (EPS) matrix provides structural integrity, metabolic cooperation, and pronounced antimicrobial toler...
Single-chain variable fragments in veterinary medicine: Intelligent design, efficient expression, and precision applications [0.03%]
单链可变片段在兽医医学中的智能设计、高效表达及精确诊疗应用
Leilei Zhang,Jiajia Jiang,Wenjing Yang et al.
Leilei Zhang et al.
The development of single-chain variable fragment (scFv) antibodies constitutes a transformative advance in veterinary biologics. However, translation into veterinary practice faces unique constraints that distinguish it from human medicine...
AI-driven discovery of multifunctional peptides: From sequence space to therapeutics [0.03%]
从序列空间到药物的多肽多功能发现及其人工智能驱动的发展
Zhiqiang Liang,Yupeng Hao,Junjie Chen
Zhiqiang Liang
Multifunctional peptides (MFPs), defined as single peptide sequences endowed with two or more biological activities, have emerged as a highly promising class of therapeutic candidates for the intervention of complex and multifactorial disea...
Shanshan Qu,Yu Li,Yong Lai et al.
Shanshan Qu et al.
With increasing awareness of health-oriented antioxidant diets, plant-derived antioxidants (PDAs) such as polyphenolics, terpenoids, vitamins, alkaloids and saponins, are promising alternatives to synthetic antioxidants (SAs). PDAs boost hu...
Tandem kinase proteins and kinase-fusion architectures in plant immune system [0.03%]
植物免疫系统中的串联激酶蛋白和激酶融合结构域
Muhammad Jawad Akbar Awan,Jasneet Singh,Naveen Kumar et al.
Muhammad Jawad Akbar Awan et al.
Tandem kinase proteins (TKPs) and kinase fusion proteins (KFPs) have emerged as a major class of intracellular immune receptors that complement classical pattern-recognition receptors (PRRs) and nucleotide-binding leucine-rich repeat (NLR) ...
Synthetic biomanufacturing of triterpenoids: From laboratory to industry [0.03%]
三萜合成生物学制造：从实验室到产业化的思考与探索
Ning Jiao,Zhanpeng Shan,Xiulai Chen
Ning Jiao
Triterpenoids are important natural secondary metabolites with diverse bioactivities, including antioxidant, anti-inflammatory, and anti-cancer properties, making them valuable for applications in the pharmaceutical, cosmetic, and food indu...
Incorporation of powerful RNA interference targets within nano-enabled co-delivery platforms for broad-spectrum resistance management [0.03%]
基于纳米技术的协同递送平台纳入高效RNA干扰靶点以实现广谱抗性治理
Jiajia Zhao,Farman Ullah,Huan Peng et al.
Jiajia Zhao et al.
The continuous escalation of pest resistance leads to the ineffectiveness of most conventional pesticides, which has posed a serious threat to global food security and public health. Metabolic resistance regulated by core detoxification enz...