The path to biotechnological singularity: Current breakthroughs and outlook [0.03%]
生物技术奇点之路：现状、展望与挑战
Zhihao Wen,Damin Yang,Yan Yang et al.
Zhihao Wen et al.
Fueled by rapid advances in gene editing, synthetic biology, artificial intelligence, regenerative medicine, and brain-computer interfaces, biotechnology is approaching a transformative era often referred to as biotechnological singularity....
Microalgal bioengineering for futuristic applications in synthetic and space biology [0.03%]
微藻生物技术在合成生物学和空间生物学中的未来应用
Rahul Mahadev Shelake,Muhammad Abdullah Khalid,Jae-Yean Kim
Rahul Mahadev Shelake
Extreme environmental conditions on Earth and in space pose significant challenges to sustaining life. As global population growth exacerbates issues such as climate change, food security, and resource depletion, innovative solutions are ne...
Susceptibility genes in plants: from molecular mechanisms to ecological implications for disease resistance [0.03%]
植物感病性基因：从分子机制到疾病抗性的生态意义
Danxia Wu,Moxian Chen,W M Wishwajith et al.
Danxia Wu et al.
Susceptibility (S) genes serve as critical regulatory elements in plant-pathogen interactions and have been successfully targeted through genome editing approaches for disease resistance improvement in numerous crop species, achieving subst...
Mechanistic modeling of lipid nanoparticle formation for the delivery of nucleic acid therapeutics [0.03%]
用于核酸药物输送的脂质纳米颗粒生成机制模型研究
Pavan K Inguva,Saikat Mukherjee,Pierre J Walker et al.
Pavan K Inguva et al.
Nucleic acids such as mRNA have emerged as a promising therapeutic modality with the capability of addressing a wide range of diseases. Lipid nanoparticles (LNPs) as a delivery platform for nucleic acids were used in the COVID-19 vaccines a...
Advances of computational protein design: Principles, strategies and applications in nutrition and health [0.03%]
计算蛋白质设计的进展：原理、策略及在营养和健康领域的应用
Ziling Zhao,Qiyang Qu,Fuwei Sun et al.
Ziling Zhao et al.
Computational methods and AI technology have played a profound impact on protein design, significantly enhancing the ability to predict protein structures and create proteins with custom-tailored functions. With the help of computational me...
Bioactive metabolites and extracellular vesicles from the marine chlorophyte genus Tetraselmis: Review [0.03%]
海洋绿藻属Tetraselmis的生物活性代谢物和细胞外囊泡：综述
Thomas Conlon,Nicolas Touzet
Thomas Conlon
Microalgal biotechnology offers sustainable applications that align with the principles of the circular bioeconomy, providing innovative and resource-efficient solutions to help achieve the United Nations' Sustainable Development Goals. Wit...
Advances in sphingan production: Biosynthesis and synthetic biology strain modification strategies based on Sphingomonas [0.03%]
鞘氨醇产生新进展：以鞘氨醇单胞菌为基础的生物合成及合成生物学菌株改造策略
Yitie Huang,Mengying Jin,Han Gao et al.
Yitie Huang et al.
The genus Sphingomonas represents a significant resource of microbial strains capable of synthesizing biopolymers. Many of these strains are capable of producing extracellular polysaccharides with diverse structures, including gellan, welan...
Capturing intrinsic protein dynamics for explaining beneficial substitutions from protein engineering campaigns [0.03%]
捕捉固有蛋白质动力学以解释来自蛋白质工程项目的有益替代品
Shuaiqi Meng,Zhongyu Li,Peng Zhang et al.
Shuaiqi Meng et al.
Directed evolution and knowledge-based design have been proven to be successful strategies for engineering proteins to desired applications. Traditional engineering strategies have focused on analyzing "hot spots" such as the substrate bind...
Enzymatic CN bond formation and cleavage reaction: Advances and perspectives [0.03%]
基于酶的CN键形成和断裂反应：进展与展望
Yaoyun Wu,Wei Song,Wanqing Wei et al.
Yaoyun Wu et al.
Cofactor-(in)dependent enzymatic systems (CNases) play a pivotal role in catalyzing the formation and cleavage of CN bonds, a critical reaction for producing a wide range of chemicals. This review provides a comprehensive analysis of the cl...
Marine fungal enzymes as potential degraders of the diverse seaweed cell-walls [0.03%]
海洋真菌酶作为褐藻细胞壁潜在降解剂的作用机制研究进展
Raquel Ledo Doval,Klaas Timmermans,Ronald P de Vries
Raquel Ledo Doval
Marine fungi play a critical yet understudied role in marine ecosystems, contributing to microbial diversity and ecological balance through their interactions with seaweed and other organisms. These interactions are essential for nutrient c...