Lentiviral-mediated CD81 modulation in the nucleus accumbens: effects on cocaine-induced conditioned reward and relapse in male rats [0.03%]
腺病毒介导的伏隔核CD81调控对雄性大鼠可卡因条件性奖赏及复吸的影响
Amine Bahi,Jean-Luc Dreyer
Amine Bahi
Cocaine use disorder is a major public health issue with no approved pharmacological treatments. Drug-associated contextual memories can trigger intense craving and relapse. Although CD81 has been linked to cocaine-induced locomotion, its r...
The caspase 11/gasdermin D pathway is a key driver of stress-induced neuroinflammation and behavioral dysfunction in rats [0.03%]
caspase 11/GSDMD途径是应激诱导的大鼠神经炎症和行为功能障碍的关键驱动因素
Soni Tiwari,Zaidan Mohammed,Aryan Tiwari et al.
Soni Tiwari et al.
Chronic low-grade inflammation is an established hallmark of stress-related psychiatric disorders. While the canonical NLRP3 inflammasome, which activates caspase 1 and IL1β, has been implicated in stress, the contribution of the non-canon...
Chihana Kabuta,Fumihiko Hakuno,Naoyuki Kataoka et al.
Chihana Kabuta et al.
α-Synuclein is a neuronal protein and main component of Lewy bodies, the pathological hallmark of Lewy body diseases such as Parkinson's disease and dementia with Lewy bodies. While the accumulation of α-synuclein in neurons is implicated...
Comparative Neurochemical and Neuroprotective Effects of Lauric Acid, Ribose-Cysteine, and Levodopa in an α-Synuclein Drosophila Model of Parkinson's Disease [0.03%]
月桂酸、核糖半胱氨酸和左旋多巴在α-突触核蛋白果蝇帕金森病模型中的神经化学和神经保护作用的比较研究
Olumayowa Kolawole Idowu,Ademola Ayodele Oremosu,Olufunke Olubusola Dosumu
Olumayowa Kolawole Idowu
Parkinson's disease (PD) entails dopaminergic neuronal loss in a gradual manner, which is typically linked to oxidative stress, neuroinflammation, and the neurotransmitter homeostasis disruption. This research compares the neurochemical and...
Retinoic acid signaling regulates astrocyte reactivity by modulating MAPK/NF-κB pathways and mitochondrial integrity [0.03%]
视黄酸信号通过调节MAPK / NF-κB通路和线粒体的完整性来调控星形胶质细胞的反应性
Seo Hyun Yoo,Dongyun Kim,Gyu-Bum Yeon et al.
Seo Hyun Yoo et al.
Astrocytes respond to inflammatory stimuli by adopting a reactive state characterized by morphological, molecular, and functional changes that affect tissue repair and disease progression. A key feature of this transformation is the metabol...
Activation of 5-HT1A receptors in the ventrolateral orbital cortex alleviates neuropathic pain-induced depressive-like behaviors via GABAergic neurons in male rats [0.03%]
激活雄性大鼠腹侧眼眶皮层中的5-ht1a受体通过胆碱能神经元缓解神经病理性疼痛引起的抑郁样行为
Yu-Long Zhao,Hui-Yuan Yi,Xue-Mei Hou et al.
Yu-Long Zhao et al.
Neuropathic pain is frequently comorbid with depression, which exacerbates patient suffering and complicates clinical management. Although the ventrolateral orbital cortex (VLO) is involved in pain processing and emotional regulation, its s...
Assessing Effects of Microwave Electromagnetic Field in APP/PS1 Mice by In Vivo GABA-weighted Imaging via Variable delay Multipulse-Chemical Exchange Saturation Transfer MRI [0.03%]
基于变延迟多脉冲交换饱和转移磁共振的GABA加权成像评估微波电磁场对APP/PS1小鼠的影响
Siqi Liu,Yan Cheng,Xiaolei Zhang et al.
Siqi Liu et al.
Electromagnetic fields (EMFs) have been shown to be beneficial in treating Alzheimer's disease (AD), but the underlying neurophysiological mechanisms remain unclear. It has been proposed that EMF promotes GABAergic neurogenesis and that abn...
Vitamin B1 Protects Against Aβ1-42-Induced HIF-1α Activation and Neurotoxicity [0.03%]
维生素B1通过保护HIF-1α活化抵抗Aβ1-42诱导的神经毒性作用
Yasmin Tarek Anderson,Katherine Priest,Jason Zastre
Yasmin Tarek Anderson
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and extensive neuronal loss, largely driven by amyloid beta (Aβ) accumulation and associated cellular stress. Vitamin B1 (thiamine) sup...
APOE4 induces sex-dependent synaptic mitochondrial cholesterol, proteome, and respiratory function alterations in mice [0.03%]
APOE4诱导小鼠性别依赖性的突触线粒体胆固醇、蛋白质组和呼吸功能的改变
Nashanthea J Roland,Johnny W Zigmond,Jane E Manganaro et al.
Nashanthea J Roland et al.
Alzheimer's disease (AD), the leading cause of dementia, is characterized by synapse damage and loss, correlating strongly with cognitive decline. APOE4, the strongest genetic risk factor for AD, impairs synapses with the mechanisms remaini...
Calcineurin inhibition mitigates activation of enteric glia in vitro and affects their crosstalk with macrophages [0.03%]
钙调神经磷酸酶抑制可减轻体外肠胶质细胞活化并影响其与巨噬细胞的相互作用
Aurora Patti,Cristiana Lucia Rita Lipari,Armando Genazzani et al.
Aurora Patti et al.
Multiple factors contribute to the physiopathology of inflammatory bowel diseases (IBD) and the enteric nervous system is emerging as a key player in this context. In particular, enteric glial cells (EGCs) share very similar properties with...