Altered microbiota drive prelimbic cortex suppression and lower pain thresholds after sleep deprivation [0.03%]
睡眠不足后肠道菌群改变驱动背侧前扣带皮层抑制及痛阈降低
Yan Wu,Na Li,Yunfeng Bai et al.
Yan Wu et al.
Sleep disturbances are increasingly recognized as a lifestyle factor for abnormal pain perception. Recent studies highlight the critical role of gut microbiota in maintaining physiological balance and reveal a bidirectional relationship bet...
Copper depletion ameliorates neuronal damage after intracerebral hemorrhage [0.03%]
铜耗竭减轻脑内出血后的神经元损伤
Wenying Zhang,Guofeng Wu,Likun Wang et al.
Wenying Zhang et al.
Background: Intracerebral hemorrhage (ICH) is a severe subtype of stroke. There are currently no specific treatment strategies for secondary brain injury and neurological deficits following ICH. Copper (Cu) is an essentia...
Genome editing in Parkinson's disease: Unlocking therapeutic avenues through CRISPR-Cas systems [0.03%]
帕金森病的基因组编辑：通过CRISPR-Cas系统开启治疗途径
Ravi Pratap Singh,Prasenjit Maity,Charu Jaiswal
Ravi Pratap Singh
Parkinson's disease (PD) is an illness that causes both motor and non-motor symptoms in the patient which occurs as a result of a progressive loss of dopamine-producing neurons in the substantia nigra. Even though the success of symptomatic...
Multiplexed neurochemical monitoring reveals glutamate modulates dopamine neurotransmission in the nucleus accumbens [0.03%]
多重神经化学监测发现谷氨酸调节伏隔核多巴胺能神经传递
Eric D Donarski,Sydney S Connors,B Jill Venton
Eric D Donarski
Dopamine (DA) and glutamate (Glu) play vital roles in cognitive function, motor control, reward systems, and addiction. However, neurotransmitters are typically measured one at a time instead of simultaneously, which would allow a better pi...
Biphasic response of silent synapses: Differential remodeling of hippocampal synaptic plasticity by status epilepticus in juvenile versus adult mice [0.03%]
静突触的双相型响应：全脑癫痫对幼年和成年小鼠海马区突触可塑性差异调节的影响
Jiali Dai,Qiao Zeng,Li Cheng et al.
Jiali Dai et al.
Objective: To investigate age-dependent mechanisms of silent-synapse transformation and their contribution to hippocampal circuit reorganization following convulsive brain injury induced by status epilepticus (SE). ...
Human Neuraminidase 3 reduces the severity of Tay-Sachs disease symptoms in a mouse model [0.03%]
人神经氨酸酶3通过减少Tay-Sachs病小鼠模型的症状严重性来发挥作用
Hande Basırlı,Volkan Seyrantepe
Hande Basırlı
Tay-Sachs disease (TSD) is a neurodegenerative disorder caused by mutations in the HEXA gene, encoding the α-subunit of β-hexosaminidase A. HexA deficiency leads to impaired degradation and accumulation of GM2 ganglioside, causing progres...
Kynureninase deficiency ameliorated monocytic recruitment and severity in a mouse model of multiple sclerosis [0.03%]
考尼乌宁酶缺乏通过减轻单核细胞募集改善小鼠多发性硬化模型的病情
Koyo Yoshidomi,Kazuo Kunisawa,Masaya Hasegawa et al.
Koyo Yoshidomi et al.
Multiple sclerosis (MS) is a common autoimmune demyelinating disease of the central nervous system (CNS). Although activation of the kynurenine (KYN) pathway has been observed in patients with MS, its pathological significance remains uncle...
Neuroinflammatory and functional outcomes after TBI are sex-dependent: Lessons from estrous-phase stratified female mice [0.03%]
TBI后神经炎症和功能预后与性别有关：来自发情期分层的雌性小鼠的教训
Tabitha Royal,Pankaj Ahluwalia,Mayuri Gulhane et al.
Tabitha Royal et al.
Traumatic brain injury (TBI) initiates complex neuroinflammatory cascades that significantly influence recovery outcomes. Although sex differences in neuroinflammation have been reported previously, findings remain inconclusive as the role ...
Acute "in vivo" LPS causes an early presynaptic C1q and C3 accumulation and increases the "prunability" of cortical synaptosomes [0.03%]
急性"LPS"诱导小鼠海马区经典补体途径活化并增加突触修剪次数
Alice Taddeucci,Veronica Torre,Nicole Rosenwasser et al.
Alice Taddeucci et al.
LPS acutely injected in 3-month-old male C57BL/6 mice (1.25 mg/kg, i.p.) were sacrificed 12 hours after the injection. LPS treatment activates complement in the central nervous system and promotes local inflammation, as confirmed by cortica...
Representation and control of remifentanil-induced hyperalgesia and pain-like hypersensitivity by distinct neural ensembles in the anterior cingulate cortex [0.03%]
前扣带回不同神经元簇表征和调控瑞米芬太尼致高敏及痛觉过敏现象
Xinyao Wang,Shu Zhao,Guangyao Li et al.
Xinyao Wang et al.
Remifentanil-induced hyperalgesia (RIH) is a common but severe clinical problem that occurs following intraoperative analgesia with remifentanil. However, it still remains unknown how RIH signals are encoded in the brain. Here, we uncover t...