Let-7a-5p Targets MAP3K1 to Regulate the MAPK Signaling Pathway in a Depression Model [0.03%]
let-7a-5p通过靶向MAP3K1调节抑郁模型中的MAPK信号通路
Shuailong Fei,Qingyun Li,Jinchen Xiang et al.
Shuailong Fei et al.
Depression is a complex and multifactorial psychiatric disorder involving the dysregulation of multiple biological processes, including inflammation, apoptosis, and synaptic plasticity. Increasing evidence suggests that microRNAs (miRNAs) p...
Parkinson's Disease as a Disorder of Synaptic Raft Integrity: A Unified Explanation for Motor Subtypes and Non-motor Symptoms [0.03%]
帕金森病作为突触微区完整性紊乱：对运动亚型和非运动症状的统一解释
Saburo Sakoda
Saburo Sakoda
Parkinson's disease (PD) has traditionally been attributed to nigrostriatal dopaminergic neurodegeneration; however, neuronal loss alone does not adequately account for the diversity of motor subtypes, variability in treatment responses, or...
TRIM31 attenuates microglia-mediated neuroinflammation via targeting TAK1 in vitro and in vivo [0.03%]
TRIM31通过靶向TAK1减弱小胶质细胞介导的神经炎症(in vitro和in vivo)
Xueying Zhao,Chi Zhang,Diange Zhang et al.
Xueying Zhao et al.
Neuroinflammation represents a central pathogenic driver in a spectrum of central nervous system disorders, predominantly mediated by microglial activation and the ensuing release of inflammatory cytokines. While the E3 ubiquitin ligase TRI...
GluN2B-containing NMDA receptors in the infralimbic cortex and sleep modulate compensatory contextual fear memory after dorsal hippocampal damage [0.03%]
内侧前额叶脑区GluN2B-NMDA受体和睡眠通过调控补偿性情境恐惧记忆形成保护海马损伤后的空间学习能力
Deepika Kant,Sushil K Jha
Deepika Kant
Fear memories are highly persistent, and identifying the neural mechanisms that support their formation is essential in understanding trauma-related neuropsychiatric disorders. Although the dorsal hippocampus (DH) plays a crucial role in co...
Microglia derived cold-inducible RNA-binding protein play a critical role in neuroinflammation and neuronal damage after cardiac arrest and resuscitation in rats [0.03%]
心肺复苏后小胶质细胞源性冷诱导RNA结合蛋白在神经炎症和神经元损伤中的关键作用
Yu Gao,Haoxin Liu,Yang Ang et al.
Yu Gao et al.
Cardiac arrest (CA) is a global health problem that accounts for more deaths than many other diseases. Global cerebral ischemia-reperfusion injury resulting from CA and resuscitation remains a critical issue that urgently requires further i...
Neurometabolite changes in cingulate cortex regions in healthy Indian population and effect of Bacopa monnieri intervention: a H1 MRS study [0.03%]
健康印度人群扣带回区域神经代谢物的变化及Bacopa monnieri干预的影响：一项H1 MRS研究
Arman Deep Singh,Mukesh Kumar,Swathi Bh et al.
Arman Deep Singh et al.
The present study investigates the age-related neuro-metabolite changes in anterior-cingulate cortex (ACC) and posterior-cingulate cortex (PCC) and their correlation with cognitive performance. The study also probes the impact of formulatio...
Targeted Stabilization of Astrocytic Cx43 Gap Junctions Reverses Depression-like Behaviors via Dual Restoration of Syncytial Networks and Glutamatergic Homeostasis [0.03%]
CX43 缝隙连接靶向稳定逆转抑郁样行为表型的机制研究：恢复合胞体内稳态和谷氨酸内稳态的双重作用
Xin-Mu Li,Meng Zhang,Zan Xing et al.
Xin-Mu Li et al.
Depression, a debilitating global mental disorder affecting millions of people worldwide, is characterized by persistent low mood and anhedonia. Growing evidence identifies astrocyte dysfunction and glutamate metabolism imbalance as core pa...
Microglia beyond boundaries: Paradigm shifts in origin, distribution, state diversity, and therapeutic regeneration [0.03%]
超越国界的小胶质细胞：起源、分布、状态多样性及治疗再生的新范式变迁
Zhida Lan,Hong Liu,Chao Huang et al.
Zhida Lan et al.
Microglia have undergone a fundamental redefinition, transitioning from traditional CNS-restricted scavengers to a highly dynamic and systemically distributed immune lineage. This review synthesizes recent paradigm shifts that challenge lon...
JNK inhibition suppresses microglial NLRP3 activation and oxidative stress but unexpectedly worsens pain in diabetic neuropathy: insights from a combined in vitro and in vivo pharmacological study [0.03%]
通过体内外药理学研究发现JNK抑制剂可减轻糖尿病神经病理性疼痛小胶质细胞NLRP3活化和氧化应激，但却意外加重了疼痛
Li Ling,Tahir Ali,Xiang Li et al.
Li Ling et al.
Diabetic neuropathy (DN) is driven by neuroinflammation and oxidative stress, with c-Jun N-terminal kinase (JNK) as a key mediator; however, the effects of JNK inhibition on neuropathic pain remain unclear. Therefore, we investigated the th...
Elamipretide (SS-31) promotes recovery by preserving mitochondrial bioenergetics and neural remodeling after spinal cord injury [0.03%]
线粒体生物能和神经重塑在脊髓损伤后的恢复中发挥重要作用——elamipretide（ss-31）的作用机制研究
Zengtao Song,Zhaoliang Ban,Haosen Zhao et al.
Zengtao Song et al.
Spinal cord injury (SCI) induces secondary damage characterized by mitochondrial dysfunction, oxidative stress, and apoptosis, which collectively impede neurological recovery. Elamipretide (SS-31) is a mitochondria-targeting peptide with po...