Effects of chemogenetic regulation of CaMKⅡα positive neurons in the ventral hippocampus on working memory impairment in the hemiparkinsonian rat [0.03%]
化学遗传学调控纹状体腹侧CAmkiiα阳性神经元对半侧帕金森病大鼠工作记忆损害的影响
Li Zhang,Chengxue Du,Mengrui Shi et al.
Li Zhang et al.
Neurons expressing Ca2+/calmodulin-dependent protein kinase Ⅱα (CaMKⅡα) in the ventral hippocampus (vHIP) play a crucial role in working memory. However, its role in Parkinson's disease (PD)-related working memory impairment remains unc...
Neuro-Nutraceutical Role Of Indian Spices, Spice Mixes And Their Bio-Actives: An update [0.03%]
印度香料、香料混合物及其生物活性物质的神经营养作用：最新研究进展
Vismaya,P S Rajini
Vismaya
Neurodegenerative disorders (NDD), one of the major health care challenges, are exponentially increasing as the elderly segment of the population continues growing in size worldwide. Currently, the role of nutraceuticals, in general and par...
Paeonol ameliorates scopolamine- and β-amyloid 1-42 oligomer-induced cognitive impairments through modulation of the TGR5-PKA-cAMP response element-binding-brain-derived neurotrophic factor pathway and inhibition of acetylcholinesterase [0.03%]
芍药醇通过调节TGR5-PKA-CREB-BDNF通路和抑制乙酰胆碱酯酶缓解东莨菪碱及β淀粉样蛋白寡聚体所致的小鼠认知障碍作用机制研究
Ye-Won Lee,Ye Eun Cho,So-Yeon Kim et al.
Ye-Won Lee et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline, synaptic dysfunction, and cholinergic signaling deficits. Paeonol (2-hydroxy-4-methoxyacetophenone), a phenolic compound derived from Paeonia ...
Epigenetic mechanisms of (electro)acupuncture in acute neuroprotection and rehabilitation of stroke [0.03%]
电针通过表观遗传机制在急性神经保护和卒中康复中的作用
Jia-Yue Wang,Ting Wu,Ling Lin et al.
Jia-Yue Wang et al.
(Electro)acupuncture is a simple, convenient, effective, and affordable therapeutic modality in traditional Chinese medicine (TCM). Guided by the principles of Inspection, Auscultation and olfaction, Inquiry, and Palpation (the four diagnos...
Lrp10 insufficiency upregulates mRNA and protein of neurotoxic α-synuclein and causes degeneration of substantia nigra dopaminergic neurons in heterozygous or homozygous Lrp10 knockout mice [0.03%]
LRP10缺乏通过上调α-突触核蛋白mRNA和蛋白质引起同基因或杂合子LRP10敲除小鼠多巴胺能神经元变性
Hung-Li Wang,Shu-Yu Liu,Ching-Chi Chiu et al.
Hung-Li Wang et al.
Heterozygous intronic mutations of LRP10 (low density lipoprotein receptor-related protein 10) gene, which produce LRP10 haploinsufficiency by impairing splicing of LRP10 mRNA and generating loss-of-function truncated LRP10, cause autosomal...
Electronic Cigarette Vapor Exposure Modifies Stroke-Induced Transcriptional and Microglial Responses in a Sex-Dependent Manner [0.03%]
电子烟气溶胶暴露以性别依赖的方式改变中风诱导的转录和小胶质细胞反应
Sophie Belle Sinder,Indy Cabeda Diaz,Shahil H Patel et al.
Sophie Belle Sinder et al.
The global rise in nicotine-containing electronic cigarette (EC) use highlights the need to understand their impact on stroke outcomes. This study examined how EC exposure affects post-ischemic inflammation in adult Sprague-Dawley rats. Bot...
Soy lysolecithin attenuates hypertension and behavioral impairments in mice fed a high-salt diet through receptor-specific regulation of prostaglandin signaling and arachidonic acid-derived prostaglandin production [0.03%]
大豆卵磷脂通过受体特异性调节前列腺素信号传导和花生四烯酸衍生的前列腺素生成来缓解高盐饮食小鼠高血压和行为障碍
Hisayoshi Kubota,Kazuo Kunisawa,Masaya Hasegawa et al.
Hisayoshi Kubota et al.
High salt (HS) intake is a major risk factor of hypertension and has been implicated in emotional and cognitive decline. On the other hand, dietary supplementation may represent a potential preventive strategy against health risks induced b...
The impact of long-term feeding with curcuminoids phospholipids enriched diet on disease progression of fALS [0.03%]
富含姜黄素类磷脂饮食对fALS疾病进程影响的长期喂养研究
Sushmitha Somanahalli Purushotham,Rose Chesworth,Nisal Keembiyage et al.
Sushmitha Somanahalli Purushotham et al.
Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal neurodegenerative disease characterised by the progressive loss of motor functions affecting both upper and lower motor neurons. Although considered multifactorial with an uncl...
Jayaraman Vinayagam,D Kalaivani,G P Senthilkumar
Jayaraman Vinayagam
Parkinson's disease (PD) is a neurodegenerative disorder characterised by neuronal loss in the substantia nigra, α-synuclein accumulation, mitochondrial impairment, oxidative stress, neuroinflammation, and apoptotic cell death. Although va...
TDP-43 expression in the cytoplasm leads to early synaptic and mitochondrial abnormalities in an inducible mouse model of ALS/FTD [0.03%]
TDP-43胞浆表达导致诱导型ALS/FTD小鼠模型早期突触及线粒体异常
Florencia Vassallu,Milagros López,Florencia López Ambrosioni et al.
Florencia Vassallu et al.
TDP-43 proteinopathy is the primary pathology associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), indicating that these neurodegenerative diseases have common underlying mechanisms. We have previously show...