Ayurvedic Herbs as neurogenesis modulators: Current understanding on their potential therapeutic relevance in enhancing neuroplasticity and cognition in aging and neurodegeneration [0.03%]
阿育吠陀草药作为神经发生调节剂的潜力及对增龄性与神经退行性疾病中促进神经可塑性和认知能力提高的治疗意义
M Muralidhara,Vismaya,V Lalith Kumar
M Muralidhara
Ayurvedic medicine, an ancient Indian health system, promotes a category of Ayurvedic herbs (AH) known as Medhya Rasayanas (nootropic rejuvenators) for cognitive enhancement and neuroprotection. Currently, AH are increasingly being studied ...
Heme oxygenase/carbon monoxide in thermoregulation and neuroenergetics [0.03%]
血红素加氧酶/一氧化碳在体温调节和神经能量代谢中的作用
Evelin Capellari Carnio,Luiz G S Branco
Evelin Capellari Carnio
This review explores the heme oxygenase/carbon monoxide (HO/CO) pathway as a central integrator of thermoregulation and neuroenergetics during inflammatory and oxidative stress. Thermoregulation is framed not merely as a homeostatic process...
Naringenin as a Multi-Target Neuroprotective Agent in Neurodegenerative Diseases [0.03%]
芸香苷作为神经退行性疾病中多靶点神经保护剂的研究进展
Nista Gurung,Dong-Young Choi,Pil-Hoon Park
Nista Gurung
Neurodegenerative diseases (ND) such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) are characterized by progressive neuronal loss driven by...
Adaptive immune signals shape neural circuit development through CNS Border-Glia pathways [0.03%]
适应性免疫信号通过CNS Border-Glia通路塑造神经回路发育
Xing Wei,Fuxian Liu,Zhenggang Shi
Xing Wei
The central nervous system (CNS) has long been considered a relatively immune-privileged site. However, accumulating evidence indicates that CNS border structures, including the meninges, choroid plexus, blood-brain barrier (BBB), and periv...
Complement System-Mediated Immunomodulation in Epilepsy: From Pathogenesis to Therapeutic Opportunities [0.03%]
补体系统介导的免疫调节在癫痫中的作用：从发病机制到治疗机会
Linqian Peng,Mengxuan Lu,Mingyue Chen et al.
Linqian Peng et al.
Epilepsy is a prevalent neurological disorder characterized by recurrent seizures and aberrant neuronal hyperexcitability. Although several antiseizure medications are clinically available, current treatments are primarily symptomatic and f...
An emerging therapeutic strategy for major depressive disorder: targeting the protein-protein interactions [0.03%]
抑郁症的新型治疗策略：作用于蛋白质-蛋白质相互作用
Xingyu Huang,Jiayan Lin,Yuan-Wei Zhang
Xingyu Huang
Major depressive disorder (MDD) is a highly heterogeneous psychiatric condition. For decades, drugs targeting serotonin transporter (SERT), such as selective serotonin reuptake inhibitors (SSRIs), have been the mainstay of treatment. Howeve...
Disturbed lipid metabolism in microglia after cerebral ischemia-reperfusion [0.03%]
脑缺血再灌注后小胶质细胞脂质代谢紊乱
Xinyu Li,Shifeng Chu,Zhao Zhang et al.
Xinyu Li et al.
Cerebral ischemia-reperfusion injury (CIRI) frequently compromises neurological outcomes in stroke patients despite successful recanalization therapy. While the brain's dense lipid network is integral to immune regulation and tissue repair,...
Phytochemical engineered quantum dots as potential therapy to counter alpha synuclein aggregation in Parkinson's disease [0.03%]
植物化学工程量子点作为潜在疗法对抗帕金森病中α-突触核蛋白聚集
Priya Shashwat,Arivarsan Vishnu Kirthi,Manickam Selvaraj et al.
Priya Shashwat et al.
Parkinson's disease (PD) is a prevalent neurodegenerative disorder that critically impairs human health and presently lacks effective cellular-level therapeutic interventions. The disease is primarily characterized by pathological aggregati...
Iron overload inhibits neuronal extracellular vesicles secretion via SNARE dysfunction [0.03%]
铁过载通过干扰SNARE功能抑制神经元释放外泌体
Xiaoting Wang,Yang Li,Xiaoqing Mi et al.
Xiaoting Wang et al.
Iron deposition in the brain is observed in several neurodegenerative diseases and aging. Extracellular vesicles (EVs), including exosomes, are critical mediators of intercellular communication. Neuron-derived EVs are recently recognized as...
Regular light-intensity exercise accelerates contextual fear extinction with reduced dorsal CA3 activation in male rats [0.03%]
规律光照下低强度运动通过降低雄性大鼠海马CA3区活动加速上下文恐惧消退
Taichi Hiraga,Ryo Shimoda,Toshiaki Hata et al.
Taichi Hiraga et al.
Exercise has gained attention as a low-cost, non-pharmacological approach for stress-related disorders such as post-traumatic stress disorder (PTSD). Regular light-intensity exercise (LIE), which is feasible even for vulnerable populations,...