Interplay and intervention of epigenetic dysregulation in traumatic brain injury pathology [0.03%]
表观遗传调控失调在创伤性脑损伤病理中的相互作用及干预措施
Samuel G Faasen,Vijay Arruri,Reid S Alisch
Samuel G Faasen
Traumatic brain injury (TBI) occurs when an external mechanical force damages brain tissue, leading to temporary or lasting disturbances in brain structure and function. The heterogeneous molecular and phenotypic nature of TBI poses a major...
A novel GSK3β inhibitor ameliorates tau aggregation and neuroinflammation in Alzheimer's disease [0.03%]
一种新型GSK3β抑制剂可改善阿尔茨海默病中的Tau蛋白聚集和神经炎症
Xin-Yue Ning,Wen-Jie Liu,Li-Jun Zhou et al.
Xin-Yue Ning et al.
In Alzheimer's disease, increased GSK3β activity drives tau phosphorylation and directly or indirectly triggers neuroinflammation, neuronal damage and cognitive decline. We previously developed a novel GSK3β inhibitor, ZLWH-60, which demo...
ERBB4 colocalizes with phosphorylated tau aggregates in multiple tauopathies [0.03%]
ERBB4与多种tau病理性磷酸化Tau聚集共定位
Chihiro Matsumoto,Tomohiro Kabuta,Terunori Sano et al.
Chihiro Matsumoto et al.
The neuregulin-ERBB4 pathway is essential for maintaining cellular function. Upon stimulation by its ligand, neuregulin, ERBB4-a receptor tyrosine kinase-triggers multiple cellular responses, including proliferation, apoptosis, differentiat...
Essential oils by name and by nature: a review of their antioxidant and neuroprotective potential in Parkinson's disease [0.03%]
以名称和性质划分的精油：其抗氧化和神经保护潜力在帕金森病中的综述研究
Claudia Cannas,Stefano Zoroddu,Alessandra Tiziana Peana et al.
Claudia Cannas et al.
Oxidative stress (OS), resulting from an imbalance between reactive oxygen species (ROS) and endogenous antioxidants, plays a central role in the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD). The brain's hi...
GDNF-AS1 mediated LHX2/METTL3/NCOA4 axis inhibits glioma progression via induction of ferroptosis [0.03%]
GDNF-AS1介导的LHX2/METTL3/NCOA4轴通过诱导铁死亡抑制胶质瘤进展
Yangbo Zhou,Zhongyue Liu,Wenjia Ma
Yangbo Zhou
Glioma, particularly glioblastoma (GBM), represents the most aggressive primary brain tumor with limited treatment options and poor prognosis. Emerging evidence highlights ferroptosis induction as a promising therapeutic strategy, while lon...
Therapeutic Potential of KATP Channels in the Attenuation of Parkinson's Disease Pathogenesis and Progression - A Review [0.03%]
钾腺苷三磷酸酶通道在帕金森病病理发生和发展中的治疗潜力-综述研究
Barbara Gundi,Hio Lam Ho,Xinyang Zhang et al.
Barbara Gundi et al.
Parkinson's disease (PD) is one of the most prevalent progressive neurodegenerative diseases today. However, existing treatments primarily focus on symptom management rather than attenuating disease progression and pathogenesis. ATP-sensiti...
Transgenerational non-genomic transmission of acquired nervous system Phenotypes: Narrative review and epigenetic insights [0.03%]
跨世代的神经系统获得性表型的非基因组传递：叙述性回顾与表观遗传学见解
Anas Abou Merhi,Vivek Sivan,Joyce Koueik et al.
Anas Abou Merhi et al.
Transgenerational epigenetic inheritance (TEI) refers to the transmission of phenotypic traits across multiple generations independent of changes in DNA sequence that are mediated by epigenetic mechanisms, including DNA methylation, histone...
Esketamine attenuates post-traumatic stress disorder via suppressing neuroinflammation and abnormal myelination [0.03%]
Esketamine通过抑制神经炎症和异常髓鞘化来缓解创伤后应激障碍
Zhaoliang Gu,Ruixue Song,Guoqiang Liu et al.
Zhaoliang Gu et al.
Background: Post-traumatic stress disorder (PTSD) is a chronic psychological disorder that is induced by traumatic events. The pathophysiological mechanism of PTSD involves complex neurobiological processes. However, the ...
Transcription Factor EB Inhibition in Response to Genotoxic Stress Promotes Apoptosis of Glioblastoma Cells [0.03%]
DNA损伤应激诱导的转录因子EB抑制促进胶质母细胞瘤细胞凋亡
Seung-Ho Park,Minseok Jeong,Min-Jeong Kong et al.
Seung-Ho Park et al.
Glioblastoma multiforme (GBM), one of the most malignant brain cancers, responds poorly to chemotherapy and surgery. Transcription factor EB (TFEB) is markedly overexpressed in GBM cells. We investigated whether TFEB contributes to resistan...
Characterizing stroke-related cellular changes in the surviving neurons of mouse ischemic stroke [0.03%]
缺血性卒中模型小鼠存活神经元的细胞内相关变化特征分析
Takeshi Ikegami,Tsutomu Sasaki,Takashi Shimbo et al.
Takeshi Ikegami et al.
Rapid restoration of cerebral blood flow through endovascular therapy is crucial for minimizing neuronal injury in ischemic stroke. This study characterized cellular and molecular alterations during the acute and subacute phases of distal m...