A novel circ_0018483/miR-4310/ERRFI1 ceRNA axis in myasthenia gravis [0.03%]
肌无力中新型circ_0018483/miR-4310/ERRFI1竞争性内源RNA轴的研究
Jie Lv,Jing Liu,Linyuan Zhang et al.
Jie Lv et al.
Background: Myasthenia gravis (MG) is one of the most prevalent disorder of the neuromuscular junction (NMJ). Non-coding RNAs regulate myoblast proliferation and differentiation. ...
Establishment of a passive-transfer mouse model of anti-NMDAR encephalitis and delineation of the PI3K-AKT-HIF-1α Axis in antibody-induced neuronal injury [0.03%]
抗NMDAR脑炎被动转移小鼠模型的建立及抗体诱导神经元损伤中PI3K-AKT-HIF-1α轴的作用机制
Huilu Li,Shifeng Zhang,Yaqing Shu et al.
Huilu Li et al.
Background and objective: Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis. Currently, the development of its animal models lacks maturity and efficiency. This study aimed...
BCL6 promotes CCR2-driven CNS infiltration of encephalitogenic Th17 cells [0.03%]
BCL6促进CCR2驱动的致脑脊髓炎性Th17细胞向中枢神经系统的浸润
Gaurav Kumar,Bujana Allushi,James L Quinn et al.
Gaurav Kumar et al.
BCL6, a transcription factor central to T follicular helper (TFH) cell differentiation, has recently been identified as a key regulator of T cell-mediated neuroinflammation. While previous research has established a connection between Th17 ...
Successful treatment with eculizumab in refractory myasthenia gravis with both anti-AChR and anti-LRP4 antibodies: two case reports [0.03%]
依库珠单抗治疗难治性自身免疫性重症肌无力2例报告
Bedriye Karaman,Göker Gören,Rasim Tuncel et al.
Bedriye Karaman et al.
Introduction: Generalized myasthenia gravis (gMG), an antibody-induced autoimmune disorder of the neuromuscular junction, is characterized by fluctuating skeletal muscle weakness and fatigability. Approximately 85% of pat...
Obsessive-compulsive symptoms and inflammatory brain changes detected using an innovative multimodal diagnostic work-up [0.03%]
利用创新的多模式诊断方法检测到的强迫症状和炎症性脑变化
Dominique Endres,Harald Prüss,Katharina von Zedtwitz et al.
Dominique Endres et al.
Introduction: Obsessive-compulsive disorder (OCD) is associated with a dysfunction of the cortico-striato-thalamo-cortical loops and overarching functional networks as well as with disturbances in serotonin, dopamine, and...
Combined inhibition of complement C5 and neonatal Fc receptor in refractory generalized myasthenia gravis: A report of two cases [0.03%]
补体C5与新生儿Fc受体联合抑制治疗难治性全身型重症肌无力的疗效观察：2例报告
Ken-Ichi Irie,Tatsuya Imai,Tamon Koga et al.
Ken-Ichi Irie et al.
In patients with refractory generalized myasthenia gravis (MG) inadequately controlled by standard immunotherapies, including intravenous immunoglobulin and intravenous methylprednisolone, molecular targeted therapies have emerged as import...
Real-world evidence on utilization and clinical outcomes of efgartigimod in patients with generalized myasthenia gravis [0.03%]
Efgartigimod在全身型重症肌无力患者中的使用情况和临床结果的现实世界证据
Lauren Miguet,Martijn De Merlier,Kristl G Claeys
Lauren Miguet
Conventional therapies for acetylcholine receptor antibody-positive (AChR-Ab+) generalized Myasthenia Gravis (gMG) often provide inadequate disease control. Although neonatal Fc receptor (FcRn) inhibitors have proven effective in clinical t...
Re-challenge of immune checkpoint inhibitor after ICI-encephalitis: A case report [0.03%]
免疫脑炎后再次使用免疫检查点抑制剂治疗的病例报告
Virginia Baker,Suma Shah
Virginia Baker
Immune-checkpoint inhibitor (ICI) related encephalitis (ICI-IE) is a severe adverse event, associated with high morbidity and mortality and requiring prompt ICI discontinuation. The safety of rechallenge with ICI after initial adverse event...
Peripheral lymphocyte subsets in spinocerebellar Ataxia type 2: Insights into disease mechanisms and potential immunomodulation [0.03%]
脊髓小脑共济失调Ⅱ型外周淋巴细胞亚群的研究：对疾病机制及潜在免疫调节的见解
Yaimeé Vázquez-Mojena,Roberto Rodríguez-Labrada,Lisis Martínez Martí et al.
Yaimeé Vázquez-Mojena et al.
Background: Spinocerebellar Ataxia type 2 (SCA2), caused by CAG repeat expansions in ATXN2, involves a multifaceted molecular pathophysiology. Although immune system involvement is an emerging area of focus in SCA2 resear...
Metalloproteinase imbalance in HIV-1: Subtype comparison in CSF and serum [0.03%]
HIV-1的金属蛋白酶失衡：脑脊液和血清亚型比较研究
Sérgio Monteiro De Almeida,Indianara Rotta,Antony Liao et al.
Sérgio Monteiro De Almeida et al.
Persistent central nervous system (CNS) inflammation, driven by ongoing HIV replication in the CNS reservoir despite antiretroviral therapy (ART), contributes to neuronal damage. We hypothesized that levels of metalloproteinases (MMPs) and ...