Clinical features and treatment response of anti-Neurofascin 155 antibody-positive neuropathy in neurological Institute of Thailand [0.03%]
泰国神经病学研究所抗神经纤连蛋白155抗体阳性神经病的临床特征及治疗反应
Narupat Suanprasert,Chaichana Sinthuwong,Metha Apiwattanakul et al.
Narupat Suanprasert et al.
Background: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated neuropathy that typically responds to conventional therapy. However, a subset of patients such as anti-neurofascin-155 (NF...
Targeting microglia: A new strategy for the treatment of Alzheimer's disease [0.03%]
靶向小胶质细胞：阿尔茨海默病治疗的新策略
Manyv Zheng,Mingjuan Yang,Wenya Su et al.
Manyv Zheng et al.
Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) plaques, neurofibrillary tangles, and chronic neuroinflammation, remains without curative therapies. Emerging evidence underscores microgli...
Identification of an immunogenic epitope from RASGRP2 with specificity for HLA-DR15 in multiple sclerosis [0.03%]
一种自身免疫性脑炎的候选病原体汉赛巴尔通体感染中国四川地区人群的研究及其致病机制探讨
Vivien Li,Kirti Pandey,Michele D Binder et al.
Vivien Li et al.
Identifying autoantigens in multiple sclerosis (MS) has been challenging. If successful, this could facilitate development of autoantigen-specific tolerogenic therapies, by exposing antigen presenting cells (APC) to tolerogenic stimuli with...
Lambert-Eaton myasthenic syndrome: Why CMAP and reflexes are not enough [0.03%]
兰伯特-伊顿肌无力综合征：为什么CMAP和反射不够可靠
Christian Messina
Christian Messina
Single-cell analysis identifies a type I interferon-associated neutrophil signature in bacterial meningitis [0.03%]
单细胞分析揭示了细菌性脑膜炎中一类与I型干扰素相关的中性粒细胞表型特征
Xiufen Zhang,Fang Zhang,Xintao Shao et al.
Xiufen Zhang et al.
Bacterial meningitis (BM) is a central nervous system infection characterized by high mortality and disability rates. Neutrophils, as the first-line innate immune cells in host defense against bacterial invasion, play a crucial role in the ...
Modeling stress-induced social and anxiety-like behaviors in mice: Towards a preclinical framework for Munchausen-like traits [0.03%]
通过小鼠建模压力引起的社交和焦虑样行为：走向类似穆诺奇森特征的临床前框架
Sanjay N Awathale,Gajendra N Pardeshi,Purvaj G Barote et al.
Sanjay N Awathale et al.
Munchausen syndrome is a psychiatric condition in which individuals feign or induce illness to gain attention, care, and sympathy. Despite being clinically recognized, its biological underpinnings remain largely unexplored, highlighting the...
Ischemic stroke induced neuronal apoptosis via IRE1α/ASK1 signaling in mice [0.03%]
IRE1α/ASK1信号调控缺血性脑卒中诱导的神经元凋亡
Han-Han Yin,Jia-Lin Gao,Xing-Yi Cao et al.
Han-Han Yin et al.
Background: Neuronal apoptosis mediated by endoplasmic reticulum (ER) stress exerts crucial pathophysiological functions in the central nervous system. Inositol-requiring kinase 1α (IRE1α), a transmembrane sensor in the...
Disturbed glucose metabolism and oxidative stress through PI3K/AKT signaling pathway in HIV-1 TAT activated retinal Müller glia [0.03%]
HIV-1 TAT激活的视网膜Müller胶质细胞中PI3K/AKT信号通路介导的糖代谢紊乱和氧化应激
Kamini Khatak,Rajesh Narayanan,Shankara Narayanan Subramaniam et al.
Kamini Khatak et al.
Müller glia are pivotal in providing a pro-survival environment for retinal cells and a sustainable energy metabolism is essential for upholding Müller glia functions. Changes in metabolic shifts impact on immune cell physiology. HIV-asso...
The TLR4/NF-κB/NLRP3 pathway is involved in levofloxacin-induced alleviation of neuroinflammation in Parkinson's disease [0.03%]
TLR4/NF-κB/NLRP3途径参与左氧氟沙星诱导的帕金森病神经炎症缓解作用
Xingyue Chen,Guoxin Zhang,Qinyu Peng et al.
Xingyue Chen et al.
Parkinson's disease (PD) is characterized by progressive motor deficits and dopaminergic neuronal loss. Aberrant neuroinflammation contributes to neurodegeneration. Prompted by published case reports describing motor improvement following l...