Erucic acid protected against dopamine neuron degeneration by attenuating oxidative stress and neuroinflammation via PI3K/AKT signaling in Parkinson's disease [0.03%]
卫尔酸通过PI3K/AKT信号通路减弱氧化应激和神经炎症来保护帕金森病多巴胺能神经元免于退行性变
Yuan Gao,Yanmei Chen,Jingjing Long et al.
Yuan Gao et al.
Background: Characterized by disabling dyskinesias, Parkinson's disease (PD) is a prevalent neurodegenerative disease, which leads to neuronal death in the substantia nigra and striatum areas of the brain. Erucic acid, an...
Prognostic value of cerebrospinal fluid and serum CXCL10 levels for neurological sequelae of viral encephalitis in children: A retrospective study [0.03%]
儿童病毒性脑炎后神经后遗症的脑脊液和血清CXCL10水平的预后价值：一项回顾性研究
Ziming Tan,Jun Wang,Mei Zhang et al.
Ziming Tan et al.
Objective: Despite advances in supportive care, predicting the prognosis of neurological sequelae in pediatric viral encephalitis (VE) remains challenging. Given that C-X-C motif ligand 10 (CXCL10) mediates leukocyte traf...
The efficacy and safety of poly ADP-ribose polymerase (PARP) inhibitors in patients with high-grade glioma (HGG): A systematic review and meta-analysis [0.03%]
聚腺苷二磷酸核糖聚合酶抑制剂治疗高级别胶质瘤疗效和安全性的系统评价和meta分析
Farhang Rashidi,Mohammadmahdi Sabahi,Ali Allahdadi et al.
Farhang Rashidi et al.
Purpose: While poly ADP-ribose polymerase (PARP) inhibitors represent a promising treatment strategy in early phase trials of patients with high-grade glioma (HGG), the clinical outcomes exhibit variability, mainly due to...
Absence of PD-1 expression on TFH and TFC cell subsets correlates with severity of multiple sclerosis [0.03%]
PD-1不在TFH和TFC细胞亚群的表达与多发性硬化的严重程度相关
Lana Márcia Ferreira Lopes,Joana Hygino,Marcos Octávio Savaterra Cafasso et al.
Lana Márcia Ferreira Lopes et al.
Follicular CD4+ T (TFH) cells have been implicated in the pathogenesis of multiple sclerosis (MS). However, studies evaluating follicular CD8+ T (TFC) cells and the relationship between TFH/TFC cells with clinical MS parameters are lacking....
Diabetes mellitus exacerbates myasthenia gravis by upregulating CD40 expression on B cells through the RAGE-HIF-1α-HK2 pathway [0.03%]
糖尿病通过RAGE-HIF-1α-HK2信号通路上调B细胞CD40表达从而恶化重症肌无力
Jing Dong,Chun-Lin Yang,Su-Yu Wang et al.
Jing Dong et al.
Background: Diabetes mellitus (DM) is a risk factor for myasthenia gravis (MG) and is known to enhance humoral immune response and antibody production in experimental autoimmune myasthenia gravis (EAMG) rats, possibly due...
Peripheral redox biomarkers in multiple sclerosis: associations with phenotype, cognition, and fatigue [0.03%]
多发性硬化症的外周氧化还原生物标志物与表型、认知和疲劳的关系
Sanja Gluscevic,Emine Rabia Koc,Aleksandra Klisic et al.
Sanja Gluscevic et al.
Background: Oxidative stress (OS) plays a pivotal role in MS pathogenesis, but its relationship with cognitive impairment, mood disorders, and fatigue remains underexplored. This study assessed blood OS markers and their ...
Comparison of mannitol versus pertussis toxin to exacerbate active experimental autoimmune encephalomyelitis (EAE) [0.03%]
关于甘露醇与百日咳毒素加重实验性自身免疫性脑脊髓炎(EAE)的比较研究
Arpita Deb,James Nichols,Alicia K Olivier et al.
Arpita Deb et al.
Experimental autoimmune encephalomyelitis (EAE) is a powerful and broadly used model to study multiple sclerosis (MS). Like most models, it has advantages and limitations; its advantages include that it can be induced in many species, the p...
Thymectomy promotes maintained complete stable remission in myasthenia gravis [0.03%]
胸腺切除术可促进肌无力的持续完全稳定缓解
Nana Zhang,Hongxi Chen,Yuntao Mo et al.
Nana Zhang et al.
Aims: This study aimed to evaluate the impact of thymectomy on the long-term prognosis of myasthenia gravis (MG) patients, using maintainable complete stable remission (mCSR) as the primary outcome. ...
Matthew C Zupan,Jack M Petersen,Addison C Stover et al.
Matthew C Zupan et al.
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that affects both the brain and spinal cord, although the brain has historically received greater attention. In the inducible, oligodendrocyte-specific k...
Methodological concerns in the cutoff determination of a flow cytometric MOG-IgG assay: The need for independent validation [0.03%]
流式细胞术MOG-IgG检测阳性截断值确定的方法学问题及独立验证的需求
Su-Hyun Kim,Fabienne Brilot,Sean Pittock et al.
Su-Hyun Kim et al.