Targeting TLR4/PPARα-mediated neuroinflammation in the prefrontal cortex: S-ketamine and S-HNK rapidly alleviate depression-like behaviors [0.03%]
靶向TLR4/PPARα介导的前额叶皮层神经炎症：S-氯胺酮和S-HNK可快速缓解抑郁症样行为
Quanfeng Zhu,Xiaoyue Zhou,Huangling Gao et al.
Quanfeng Zhu et al.
Neuroinflammation, particularly Toll-like receptor 4 (TLR4)-mediated signaling, plays a critical role in the pathophysiology of depression. This study aimed to investigate the mechanisms by which S-ketamine (S-ket) and S-hydroxynorketamine ...
Mefenamic acid attenuates NLRP3-associated neuroinflammation and mitochondrial dysfunction and is associated with prevention of long-term cognitive impairment after sepsis [0.03%]
甲灭酸可减轻脓毒症后的NLRP3相关的神经炎症和线粒体功能障碍并有助于预防长期认知障碍
Diogo Dominguini,Emily Córneo,Carla Sasso Simon et al.
Diogo Dominguini et al.
Sepsis survivors frequently develop long-term cognitive impairment, but the mechanisms linking systemic infection to persistent brain dysfunction remain incompletely understood. Mitochondrial dysfunction and NLRP3 inflammasome activation ha...
Chronic pain despite lower lesion burden in double-seronegative longitudinally extensive transverse myelitis [0.03%]
双阴性的长节段横贯性脊髓炎患者慢性疼痛的发病机制及其与病灶负荷的关系研究
Yumin Jin,Dayoung Seo,Habin Yun et al.
Yumin Jin et al.
Background: Chronic pain is a frequent complication of longitudinally extensive transverse myelitis (LETM). In neuromyelitis optica spectrum disorder-associated transverse myelitis (NMOSD-TM), pain has been largely attrib...
Evaluation of neuronal and immunological biomarkers in post-COVID-19 condition [0.03%]
评估新冠肺炎后遗症的神经元和免疫学生物标志物
Graziele de Souza Fonseca,Raphael de Mello Carpes,Marcela Espindola Palmeira Pereira et al.
Graziele de Souza Fonseca et al.
Objective: To investigate evidence of central nervous system (CNS) injury in Post-COVID-19 Condition (PCC) through plasma biomarkers of neuronal damage (APP, NfL, Tau), inflammation (IL-2, IL-6, IL-10, IL-18, IFN-γ, TNF-...
Association between 6-month outcomes and the systemic inflammatory response index, HMGB1, and IL-33 levels in patients with traumatic spinal cord injury: A retrospective cohort study [0.03%]
系统性炎症反应指数、HMGB1和IL-33水平与创伤性脊髓损伤患者6个月预后的相关性：回顾性队列研究
Rongkun Liao,Hong Yin
Rongkun Liao
Background: Spinal cord injury (SCI) is a devastating condition characterized by variability in injury mechanisms and neurologic recovery. Complex reactive cellular responses and the release of cytokines, which may be cli...
Antidepressant-like effects of Nidus vespae fraction: Evidence from monoamine uptake inhibition, behavioral, biochemical, and histopathological studies [0.03%]
日本黄蜂巢药理分数的抗抑郁作用：来自单胺重摄取抑制、行为学、生化和组织病理学研究的证据
Pramod Nikam,Sunil Kumar Kadiri,Vishnu A Kangralkar
Pramod Nikam
Background: Depression is a complex neuropsychiatric disorder involving monoaminergic imbalance, oxidative stress, and neuronal dysfunction. Limitations of current antidepressant therapies necessitate the exploration of s...
Coordinated oxidative shift during relapse and recovery in multiple sclerosis: A paired analysis of multiple biomarkers [0.03%]
多发性硬化复发和恢复期间的协调氧化转移：多种生物标志物配对分析
Caner Baydar,Abdullah Yılgör
Caner Baydar
Background: Oxidative stress plays a central role in the pathogenesis of multiple sclerosis (MS), contributing to inflammation, demyelination, and neurodegeneration. Acute relapse periods may represent a critical phase ch...
Perioperative Administration of Efgartigimod in myasthenia gravis patients with Thymoma: A six-case series [0.03%]
胸腺瘤重症肌无力患者围手术期使用Efgartigimod治疗的六例病例系列研究报告
Qiurong Yang,Shan Yu,Xiaoshuang Wang et al.
Qiurong Yang et al.
Background: Efgartigimod, an FcRn antagonist for AChR antibody-positive generalized myasthenia gravis (gMG), has not been well explored for thymectomy perioperative management. Compared to conventional IVIg or plasmaphere...
Real-world risks of neurotoxicity with immune checkpoint inhibitors compared with standard chemotherapy [0.03%]
免疫检查点抑制剂与传统化疗相比产生神经毒性的实际风险比较
Alexandra Balshi,John P Dempsey,Yanli Zhang-James et al.
Alexandra Balshi et al.
Background: Although reports of immune checkpoint inhibitor-related neurotoxicity are mounting, the relative risks of neurologic complications compared with conventional chemotherapy (also associated with neurotoxicity) r...
Response to comments on cutoff determination of a flow cytometric MOG-IgG assay: Assay interpretation beyond a single threshold [0.03%]
关于流式细胞仪MOG-IgG检测截断值确定的相关评论：单一阈值之外的试验解读
Young Nam Kwon,Seong-Il Oh,Sung-Min Kim
Young Nam Kwon