Functional immune responses to PI3K pathway inhibition in PBMCs from schizophrenia patients without metabolic syndrome [0.03%]
无代谢综合征的精神分裂症患者外周血单个核细胞对PI3K通路抑制的功能性免疫反应
Vivian T da Silveira Anício,Ingrid Caroline Silva Dias,Érica Leandro Marciano Vieira et al.
Vivian T da Silveira Anício et al.
Introduction: Schizophrenia (SCZ) is a mental disorder characterized by complex interaction between genetic and environmental factors, mediated by molecular events, including alterations in components of the PI3K/GSK3/mTO...
Novel genes associated with hypocretin-producing neurons identified by human gene expression profiling [0.03%]
通过人类基因表达谱鉴定与下丘脑素神经元相关的新型基因
Marieke Vringer,Ahmed Mahfouz,Maartje G Huijbers et al.
Marieke Vringer et al.
Narcolepsy type 1 is a sleep-wake disorder characterized by hypocretin deficiency. It has been considered an autoimmune disorder for decades due to the strong associating with the HLA-DQB1*06:02 allele and possible relations to the H1N1 pan...
Isolated oculomotor dysfunction with downbeat nystagmus as a rare presentation of anti-GAD autoimmunity [0.03%]
抗GAD自身免疫罕见的孤立性动眼神经障碍并下向注视性眼球震颤表现
A Zolin,A Porsio,F Rossato et al.
A Zolin et al.
Background: Glutamic acid decarboxylase (GAD) antibodies are associated with a range of autoimmune neurological syndromes, including cerebellar ataxia (CA). Ocular motor disturbances such as nystagmus and diplopia are fre...
Transient global amnesia as a paraneoplastic manifestation of small cell lung cancer [0.03%]
小细胞肺癌的副肿瘤综合征性一过性全球遗忘症
Abdulrehman Bhatti,Hugo Morales Briceno,Pei Ding et al.
Abdulrehman Bhatti et al.
Objectives: To describe an unusual presentation of paraneoplastic autoimmune encephalitis manifesting as transient global amnesia (TGA). Methods: ...
Targeted proteomic profiling of serum and CSF reveals CASP-8 as a candidate biomarker in anti-NMDAR encephalitis [0.03%]
靶向蛋白质组学揭示CASP-8可作为抗NMDAR脑炎的生物标志物
Sonja Kosek,Anna Wiberg,Barbro Persson et al.
Sonja Kosek et al.
Anti-NMDA receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system involving both B- and T-cell activation. In this exploratory study, targeted proteomics was used to characterize protein expression profiles in ...
Real-world experience with switching from intravenous immunoglobulin to subcutaneous efgartigimod PH20 in patients with chronic inflammatory demyelinating polyradiculoneuropathy: A case series [0.03%]
慢性炎症性脱髓鞘多发神经根病患者从静脉注射免疫球蛋白切换为皮下注射EFgartigimod PH20的现实世界经验：病例系列报告
Raghav Govindarajan
Raghav Govindarajan
Introduction/aims: In the ADHERE trial (NCT04281472), subcutaneous (SC) efgartigimod PH20 provided clinical benefit in participants with worsening chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), regardle...
Systemic and neurologic autoimmune disorders and antibody seropositivity associated with neurosarcoidosis [0.03%]
与神经囊性组织病相关的系统性和神经学自身免疫性疾病和抗体阳性检测结果
Danielle Pitter,Esme Trahair,Frehiywot Ayele et al.
Danielle Pitter et al.
Background: Comorbid autoimmune disorders and non-specific antibody seropositivity have been commonly reported in prior studies of systemic rheumatologic disorders and neuroimmune diseases. As a disorder without a reliabl...
Germinal centers are associated with poor prognosis in patients with thymoma-associated myasthenia gravis [0.03%]
胸腺瘤伴发重症肌无力患者的坏死性中心与不良预后相关
Hye Yoon Chung,Ha Young Shin,Hyung Jun Park et al.
Hye Yoon Chung et al.
Background: Germinal centers (GCs) can be observed in the thymic tissues of individuals with thymoma-associated myasthenia gravis (TAMG). This study aimed to investigate the association between the presence of GCs in the ...
Tracking the invisible: Impact of disease-modifying therapies on serum neurofilament light chain and clinical outcomes in treatment-naïve multiple sclerosis [0.03%]
隐形追踪：疾病修正治疗对初治多发性硬化症患者血清神经丝轻链和临床结局的影响
Eman M Khedr,Nourelhoda A Haridy,Hussein Bahey El-Deen et al.
Eman M Khedr et al.
Background: Disease-modifying therapies (DMTs) are widely used to manage multiple sclerosis (MS), but their effects on serum neurofilament light chain (sNfL), particularly in drug-naïve patients, remain underexplored. Th...
Diagnosis of Lambert-Eaton myasthenic syndrome: Muscle fatigue with normal manual muscle testing, areflexia, and electrodiagnostic findings [0.03%]
Lambert-Eaton肌无力综合征的诊断：查体近端肌力正常、腱反射减退、疲劳试验阳性及电生理改变
Hideo Handa,Akiyuki Uzawa,Kazumoto Shibuya et al.
Hideo Handa et al.
Objective: This study aimed to identify clinically relevant features for the diagnosis of Lambert-Eaton myasthenic syndrome (LEMS) and to elucidate factors associated with diagnostic delay in LEMS. ...