Plasma IL-24 is associated with time to first fall in Parkinson's disease [0.03%]
帕金森病患者血浆IL-24水平与首次跌倒时间的关系
Kazuhiro Iwaoka,Keita Taguchi,Sayuri Oikawa et al.
Kazuhiro Iwaoka et al.
Plasma inflammatory protein biomarkers associated with clinical milestone heterogeneity in Parkinson's disease (PD) remain undefined. We measured 92 inflammation-related plasma proteins in 82 PD patients using the Olink Proximity Extension ...
Identification of PTGS2 as a genetically supported protective biomarker and potential therapeutic target in myasthenia gravis [0.03%]
PTGS2作为遗传支持的保护生物标志物和重症肌无力潜在治疗靶点的鉴定
Yuwei Li,Minxue Zhang,Zhan Liu
Yuwei Li
Background: Myasthenia Gravis (MG) is an autoimmune disease that damages the neuromuscular junction (NMJ), reduces the transmission of nerve impulses to muscles, and thus causes fluctuating muscle weakness and fatigue. Th...
Christian Messina
Christian Messina
Epstein-Barr virus and multiple sclerosis: Mechanisms, therapeutic implications, and emerging interventions [0.03%]
EB病毒和多发性硬化症：机制、治疗意义及新兴干预手段
Mohamed Reda Fazazi,Kevin Champagne-Jorgensen,Tamanna Islam et al.
Mohamed Reda Fazazi et al.
Multiple sclerosis (MS) is a neuroinflammatory disease shaped by genetic and environmental factors, with Epstein-Barr virus (EBV) emerging as the strongest environmental risk. Here, we review current evidence for the involvement of EBV in M...
Lesion burden determines the incremental diagnostic value of intrathecal IgG oligoclonal bands synthesis in multiple sclerosis [0.03%]
病灶负荷决定寡克隆带在多发性硬化症诊断中的增量价值
Valentina Annamaria Mauceri,Davide Di Mare,Francesca Rinaldi et al.
Valentina Annamaria Mauceri et al.
Background: The 2024 revision of the McDonald criteria allows the diagnosis of multiple sclerosis (MS) based on dissemination in space alone when ≥4 typical lesion locations are present, raising the question of how lesio...
Typhoid fever and malaria co-infection alters brain structures and impairs spatial working memory in Wistar rats [0.03%]
伤寒和疟疾共感染可改变大鼠脑结构并损害空间工作记忆能力
Ngouateu Omer Bébé,Kede Kede Leon Daniel,Kandeda Kavaye Antoine et al.
Ngouateu Omer Bébé et al.
Typhoid fever and malaria co-infection have been documented since the 19th century in addition to its significant impact on global population. The aim of the present study was to investigate the potential neurological damages of typhoid fev...
A systematic review and meta-analysis of OCT-based ophthalmic changes in amyotrophic lateral sclerosis [0.03%]
基于OCT的ALS眼底变化的系统评价和meta分析研究
Asmar Ahsan,Ju-Chi Ou,Pritha Majumder et al.
Asmar Ahsan et al.
Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease marked by motor decline and respiratory failure. Optical coherence tomography (OCT), a non-invasive imaging technique, has been ex...
Multi-omics analyses nominate THBS1 as a regulator of an inflammatory microglial state after intracerebral hemorrhage [0.03%]
多组学分析提名THBS1为脑内出血后炎症性小胶质细胞状态的调节因子
Dawei Zhang,Jian Yang,Youjia Qiu et al.
Dawei Zhang et al.
Neuroinflammation is a major determinant of secondary injury after intracerebral hemorrhage (ICH), but the microglial states that drive this process and their upstream regulators remain incompletely resolved. We integrated public single-cel...
Presenting and residual movement disorders in all-cause autoimmune encephalitis [0.03%]
全身性自身免疫性脑炎的呈现和残留运动障碍
Samhitha M Rai,Sophia F Damman,Bijoya Basu et al.
Samhitha M Rai et al.
Background: Movement disorders are among the most common autoimmune encephalitis (AE) symptoms, yet their detailed phenomenology and impact remain underexplored. ...