Tumor heterogeneity involving SCLC with a single exon deletion in RB1 and adenocarcinoma with EGFR-L718V mutation in EGFR-TKI-resistant lung cancer [0.03%]
耐药性肺癌肿瘤异质性涉及RB1单一外显子缺失的SCLC和EGFR具有EGFR-TKI突变的肺腺癌
Sho Kakuto,Ken Uchibori,Yuri Yamamoto et al.
Sho Kakuto et al.
Introduction: EGFR tyrosine kinase inhibitors (EGFR-TKIs) have significantly improved the outcomes of EGFR-mutant non-small cell lung cancer (NSCLC); however, resistance commonly develops. While secondary EGFR mutations (...
Tarlatamab population survival kinetics in extensive-stage small cell lung cancer: brief report [0.03%]
关于大范围小细胞肺癌患者使用tarlatamab后的生存动力学的简短报告
David J Stewart,Bingnan Zhang,Razelle Kurzrock
David J Stewart
Purpose: Immune checkpoint inhibitors (ICIs) prolong progression-free survival (PFS) and overall survival (OS) in extensive-stage small cell lung cancer (ES-SCLC). ES-SCLC PFS curve exponential decay nonlinear regression ...
Genetic composition and evolutionary trajectories of brain metastasis in non-small-cell lung cancer [0.03%]
非小细胞肺癌脑转移的基因组成和进化轨迹
Marcin Nicoś,Natalia Galant,Anna Kowalczyk et al.
Marcin Nicoś et al.
Introduction: Non-small cell lung cancer (NSCLC) is an aggressive solid malignancy that commonly disseminates to the central nervous system (CNS). Comparative analysis of primary NSCLC and brain metastases (BM) by next-ge...
Impact of N1 lymph node burden on survival outcomes in non-skip pN2 non-small-cell lung cancer [0.03%]
N1淋巴结负荷对非跳过pN2期非小细胞肺癌生存结局的影响
Bin Luo,Shenhua Liang,Leqi Zhong et al.
Bin Luo et al.
Objectives: This study aimed to evaluate the prognostic value of quantitative N1 nodal burden metrics-including positive node count, positive station count, lymph node ratio (LNR), and lymph node station ratio (LNsR)-in p...
NHWD-870 suppresses tumor proliferation via the BRD4/STRADA/CCND1 axis in small cell lung cancer [0.03%]
NHWD-870通过BRD4/STRADA/CCND1轴抑制小细胞肺癌的增殖
Linrui Ma,Xiangyu Zhang,Shidong Xu et al.
Linrui Ma et al.
Background: Small cell lung cancer (SCLC) is a highly aggressive malignancy with poor prognosis and limited therapeutic options. The lack of effective targeted therapies for SCLC is a major limitation of this field. Bromo...
Prevalence and molecular landscape of NRG1 fusions in Japanese solid tumors: a nationwide data analysis using the C-CAT database [0.03%]
日本实体肿瘤NRG1融合的患病率和分子特征全国数据分析：基于C-CAT数据库的研究
Masaki Ishida,Tadaaki Yamada,Ryo Tsunashima et al.
Masaki Ishida et al.
Introduction: Neuregulin 1 (NRG1) gene fusions are critical oncogenic drivers that activate the ERBB signaling pathway across various solid tumors. Although targeted therapies for NRG1 fusion-positive cancers are advancin...
Threshold of adequate resection margin for sub-lobar resection in peripheral clinical stage IA1-2 non-small cell lung cancer with tumor spread through air spaces [0.03%]
周围型临床IA1-2期肿瘤伴癌细胞沿肺泡壁内扩散的非小细胞肺癌亚肺叶切除切缘阳性切缘阈值研究
Hanbo Pan,Hui Yin,Wanyu Li et al.
Hanbo Pan et al.
Objectives: Sub-lobar resection (SR) is an established treatment for peripheral clinical stage IA1-2 (cIA1-2) non-small cell lung cancer (NSCLC). However, it may fail to achieve complete resection and is associated with w...
Impact of immune-related and non-immune related hospital admissions on survival of patients with non-small cell lung cancer receiving first-line immunotherapy [0.03%]
免疫相关和非免疫相关住院对接受一线免疫治疗的非小细胞肺癌患者生存影响的研究
Adam Khorasanchi,Mingjia Li,Songzhu Zhao et al.
Adam Khorasanchi et al.
Background: Patients with metastatic non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICIs) are at risk for severe immune-related adverse events (irAEs). Limited data exists on the association...
Treatment outcomes in patients with stage IV large cell neuroendocrine carcinoma: a nationwide registry study [0.03%]
IV期大细胞神经内分泌癌患者的治疗结局：一项全国登记册研究
Frank W J Heijboer,Jules L Derks,Francien H van Nederveen et al.
Frank W J Heijboer et al.
Introduction: Overall survival (OS) of patients with stage IV large cell neuroendocrine carcinoma (LCNEC) is poor and optimal systemic treatment is unknown. Here, we describe clinical outcomes per treatment strategy of pa...