Vijender Kalmotia
Vijender Kalmotia
Accurately analyzing gene expression changes in high- throughput perturbation studies remains a challenge due to confounding technical factors. This paper evaluates and extends the SCEPTRE (Single-Cell PerTurbation screens via Conditional R...
Self-organised and disorganised dissipative structures as energy-entropy pumps [0.03%]
自组织和非组织耗散结构作为能量-熵泵
Shripad P Mahulikar,Aitor Erkoreka
Shripad P Mahulikar
Entropy pumping (2nd Law counterpart of energy pumping) is fundamental to the existence of dissipative structures, DS. In this study, DS is conceptually shown to have an energy pump for non-spontaneous mass-energy in-flows, followed by an e...
State-dependent gut-brain electrophysiological coupling tracks motor complication severity in Parkinson's disease [0.03%]
状态依赖性肠-脑电生理耦合可追踪帕金森病运动并发症的严重程度
Sanket Houde,Mansimran Kaur,Hari Prakash Tiwari et al.
Sanket Houde et al.
Background: Numerous studies have shown abnormalities in both cortico-basal ganglia dynamics and gut function in Parkinson's disease (PD). Research investigating the effects of oral levodopa medication in PD has primarily...
Internal constraints and structured possibility: A formal nomogenetic framework for modular biological systems [0.03%]
内在限制和结构可能性：模块化生物系统的正式nomogenetic框架
David Ben-Gershon Chernoguz
David Ben-Gershon Chernoguz
Modular biological systems occupy a tiny fraction of their combinatorial design spaces, yet no mathematical framework has derived this sparsity from explicit axioms or bounded it quantitatively. We develop a formal nomogenetic framework for...
Membrane information organization at the origin of life: From interfaces to informational bodies [0.03%]
生命起源的膜信息组织：从界面到信息体
Seyed Kiarash Sadat Rafiei,Mahsa Asadi Anar
Seyed Kiarash Sadat Rafiei
Membranes are usually treated as passive containers in origin-of-life models, confining prebiotic chemistry, buffering diffusion, and sustaining gradients. Here, we argue that early membranes provided the physical substrate for candidate in...
The future is flow: Embodied constructal design for human creativity [0.03%]
流动的未来：人体创造力的设计构型理论与实践研究
Christine Bizzell
Christine Bizzell
Human creativity has been associated with flow-a distinct experiential state identified by Mihaly Csikszentmihalyi in which attention, intention, and action align in the pursuit of meaningful challenge. These experiences have been shown to ...
Stress-triggered cell elimination stabilizes resource-limited cell collectives: An agent-based model [0.03%]
基于代理的模型引发压力的细胞消除可稳定资源受限的细胞集体
Bertan Korkmaz
Bertan Korkmaz
Mitochondria, long regarded as the cell's "powerhouses", also serve as intracellular quality-control modules that promote the elimination of damaged or proliferatively dysregulated cells. Alongside their energetic benefits, mitochondrial ap...
A categorical sketch for viability: Formalising the structural invariants of self-organising systems [0.03%]
一个关于可行性的范畴草图：自组织系统结构不变量的正式化
Christopher Keo
Christopher Keo
We work in Set and define a P-system as a state object S with a self-production endomorphism φ:S→S, a functional membrane ∂S↪S, and a flux action ρ:R×S→S. The endomorphism is evaluation-based: φ reads the currently installed metabol...
A V Melkikh
A V Melkikh
A review of mutation mechanisms across a range of organisms (including viruses, bacteria, insects, animals, and humans) has been performed. Considering the complexity of their genomes and population sizes, it is concluded that mutations lea...
The biological cosmological constant ΛB: Exploratory propensity, dynamical habitability and the geometric origin of life [0.03%]
生物宇宙学常数Λ_B：探索倾向、动力栖居性及生命几何起源
Richard A Fariña,Sebastián Vallejo
Richard A Fariña
The emergence of life represents a fundamental geometric phase transition in the state space of complex systems, rather than a mere sequence of chemical syntheses. Building upon the framework of Biorelativity, we introduce ΛB, the biologic...