Discrete minds: Stanisław Ulam, automata, and the mathematical recasting of biological pattern recognition [0.03%]
离散思维：斯坦尼斯瓦夫·乌拉姆、自动机与数学模式识别再现生物学模式
Alberto Bardi
Alberto Bardi
This article reconstructs Stanisław Ulam's significance for postwar biology and cognition not as the author of a single biological theory but as a contributor to a transformation in representational form. Drawing on Los Alamos reports, Ula...
The hill coefficient as Fisher information: An information-theoretic identity for allosteric cooperativity [0.03%]
希尔系数作为费舍信息：别构协作的信息理论恒等式
Bharath G Srivats
Bharath G Srivats
The Hill coefficient nH has quantified cooperative binding in biology for over a century, yet its information-theoretic content is rarely made explicit. We prove a sharply local algebraic identity: for a Hill-type dose-response curve, the F...
A continuum of bacterial coexistence equilibrium states sustains mcr-mediated colistin resistance at the human-animal interface [0.03%]
人畜共患的黏菌素耐药性维持介体MCr所支持的细菌共生平衡状态的连续体
Jhoana P Romero-Leiton,Yuliana Rodriguez,Carlos Bastidas-Caldes et al.
Jhoana P Romero-Leiton et al.
Colistin represents one of the last therapeutic options against multidrug-resistant gram-negative bacteria; however, the ecological mechanisms sustaining plasmid-mediated resistance at the human-animal interface remain poorly understood. We...
Protocode Mats and Living Membranes: A New Hypothesis for the Origin of the Standard Genetic Code [0.03%]
原核遗传密码的起源新假说：编码矩阵与生活膜学说
Alexander Nesterov-Mueller,Dimitry Schmidt
Alexander Nesterov-Mueller
The standard genetic code (SGC) maps 64 codons to 20 amino acids and three stop codons. The Combinatorial Fusion Cascade (CFC), introduced in 2020, identified three combinatorial rules that reproduce all 64 codon-amino acid assignments thro...
Fractional dynamics of socio-ecological collapse: Nonlocal memory operators and hereditary stability in coupled human-Earth systems [0.03%]
社会生态崩溃的分数动力学：人类-地球耦合系统中的非局部记忆算子和遗传稳定性
A El Amri,H Moussa,H Sabiki
A El Amri
Inspired by the coupled human-Earth system framework of Anderies et al. (2023), we develop a fractional-order extension using Caputo derivatives to model memory effects in socio-ecological collapse dynamics. The model describes interactions...
Breno B Just,Sávio Torres de Farias
Breno B Just
Living systems implement a suit of informational processes in the service of driving appropriate actions. The multitude of cellular signaling pathways has been described as enabling organisms without nervous system to implement cognitive pr...
The central homeorhetic principle: Lipid-organized boundary systems as constraints on cellular state realization [0.03%]
中心同律原理：脂质组织边界系统作为细胞状态实现的限制因素
Cheng Wang
Cheng Wang
Sequence information can specify molecular components, but specification is not equivalent to cellular state realization. A gene product contributes to living function only when gradients persist, compartments remain intact, diffusion and p...
Massimo Di Giulio
Massimo Di Giulio
The theory is presented according to which the domains of life are identified by their genetic codes. That is to say, each progenote->cell transition, the evolutionary point in the formation of a domain of life, is associated with a unique ...
Topological Neural Coding: The associative memory representation of graphs, groups and knots [0.03%]
拓扑神经编码：图、群和纽结的联想记忆表示法
Andrés Pomi,Santiago A Bosch-Roascio
Andrés Pomi
The idea of having a representation capable of unifying all branches of knowledge has been envisioned throughout different eras. Cognitive neuroscience has shown that human symbolic and cultural activities consistently evoke distinct activa...
Teleonomy and Synergy: How Living Systems Have Shaped Biological Evolution [0.03%]
目标论和协同作用：生命系统如何影响生物进化
Peter A Corning
Peter A Corning
Charles Darwin's theory of evolution was seriously deficient. Although his concept of natural selection was an important contribution - highlighting the fundamental fact that life on Earth is a contingent, always at-risk enterprise - he fai...