Construction and validation of a risk prediction model for recurrent pregnancy losses in patients with positive antiphospholipid antibodies [0.03%]
阳性抗磷脂抗体人群复发性流产风险预测模型的构建及验证
Yang Chen,Xiaoning Ma,Yue Zhang et al.
Yang Chen et al.
To identify independent risk factors for recurrent pregnancy loss (RPL) among antiphospholipid antibody (aPL)-positive individuals who were either in early pregnancy (≤12 weeks' gestation) or not pregnant, and to develop and validate a ris...
AHSA1-DNAJB4 axis: A regulatory mechanism that initiates the ERAD pathway to facilitate endometrial cancer progression [0.03%]
AHSA1-DNAJB4轴：启动ERAD途径以促进子宫内膜癌进展的调节机制
Zhongxue Ye,Chen Yu,Siyu Cao et al.
Zhongxue Ye et al.
Endometrial cancer (EC) is a malignant neoplasm with a high prevalence, posing a significant threat to women's health and a substantial burden on the healthcare system. The endoplasmic reticulum-associated degradation (ERAD) pathway is esse...
Recurrent pregnancy loss and targeted immunotherapy: Mechanistic insights and the role of biologic disease-modifying anti-rheumatic drugs [0.03%]
复发性妊娠丢失与靶向免疫治疗：机制见解及生物制剂改变病情抗风湿药的作用
Marcelo Borges Cavalcante,Marcela Torres de Melo Cavalcante,Daniel de Sousa Sobral et al.
Marcelo Borges Cavalcante et al.
Recurrent pregnancy loss (RPL) is a complex condition with heterogeneous etiologies, increasingly recognized to involve immune dysregulation. In a subset of women with unexplained RPL, abnormal maternal immune activation-characterized by an...
Balancing IL-17: Implications for immune tolerance, pregnancy outcomes, and reproductive health [0.03%]
IL-17的平衡：对免疫耐受、妊娠结局和生殖健康的意义
Jarupa Soongsathitanon,Sutatip Pongcharoen
Jarupa Soongsathitanon
Interleukin-17 (IL-17), a pro-inflammatory cytokine best known for its role in autoimmune disease, has emerged as a key immunomodulator in pregnancy. Its presence at the maternal-fetal interface reflects a finely tuned balance in which IL-1...
Endothelial glycocalyx damage underlies the generalized endothelial dysfunction in preeclampsia [0.03%]
妊娠高血压的血管内皮功能障碍源于内皮糖萼损伤
Marco Scioscia,Sandra M Blois,Gustaaf Dekker et al.
Marco Scioscia et al.
In pregnancy, endothelial dysfunction serves as a key mechanism linking maternal-fetal immune maladaptation and soluble antiangiogenic factors to the clinical presentation of preeclampsia. Although most of these aspects have been elucidated...
Chronic histiocytic intervillositis: Insights into immunopathogenesis and prospective treatments [0.03%]
慢性绒毛间质组织细胞增生症：免疫病理机制及治疗前景的启示
Morgan Jean Bell-Ricketts,Imogen Alice Porter-Wright,Katrina Borovika et al.
Morgan Jean Bell-Ricketts et al.
Chronic histiocytic intervillositis (CHI) is a rare placental inflammatory disorder associated with adverse pregnancy outcomes, including fetal growth restriction, miscarriage, and stillbirth. Its diagnosis is made retrospectively via histo...
Abnormal expression of ILT2, NKG2D and NKp46 receptors on natural killer cells in women with unexplained recurrent implantation failure [0.03%]
ILT2、NKG2D和NKp46受体在不明原因反复种植失败患者外周血自然杀伤细胞上表达异常
Yingying Zhang,Xi Yan,Jingya Wu et al.
Yingying Zhang et al.
Recurrent implantation failure (RIF) refers to the repeated failures of embryo implantation during assisted reproductive technology and half of them remain unexplained (uRIF). Evidence has proven the association between uRIF and immune dysr...
Mengjiao Kuang,Fei Fu,Menghua Kuang et al.
Mengjiao Kuang et al.
Arachidonic acid (AA) is an essential polyunsaturated fatty acid in humans and a key component of the phospholipid bilayer in cell membranes. Under various stimuli, AA is released from phospholipids; however, elevated levels of AA can act a...
Endometrial microbiota in maternal-fetal tolerance: An in vitro study of extravillous trophoblasts and uNK cells [0.03%]
子宫微生态在母胎免疫耐受中的作用：体外实验研究滋养细胞和uNK细胞
Kazuhide Takada,Yoshinori Takeda,Jonghyun Bae et al.
Kazuhide Takada et al.
Accumulating clinical studies have reported the significance of endometrial microbiota during pregnancy, especially in assisted reproductive technology. Although there are discussions on the relationship between endometrial microbiota and i...
Gut microbiota and pattern recognition receptors in polycystic ovary syndrome [0.03%]
多囊卵巢综合征中的肠道微生物群和模式识别受体
Jintao Yuan,Shiqiong Sun,Essam H Ibrahim et al.
Jintao Yuan et al.
Polycystic ovary syndrome (PCOS) is increasingly recognized as a disorder of impaired immune-endocrine homeostasis. Emerging evidence indicates that intestinal dysbiosis and microbial metabolite imbalance can activate pattern recognition re...