OPRK1 insufficiency results in trophoblast dysfunction and correlates with preeclampsia pathogenesis [0.03%]
OPRK1缺乏导致滋养细胞功能障碍并可能与子痫前期发病机制相关
Yi Yuan,Weihong Zeng,Linlin Song et al.
Yi Yuan et al.
Aberrations in trophoblast proliferation, invasion and hypoxia adaptation are implicated in pregnancy-related complications. OPRK1, encoding the κ-opioid receptor 1, is a member of the G protein-coupled receptors. In this study, we observe...
Age-dependent effects of low-molecular-weight heparin in recurrent implantation failure: A retrospective cohort study [0.03%]
低分子肝素在反复种植失败中的年龄依赖性影响：一项回顾性队列研究
Wenjing Wan,Yujia Ren,Yan Zhao et al.
Wenjing Wan et al.
This study aims to evaluate the effect of low molecular weight heparin (LMWH) on pregnancy outcomes in recurrent implantation failure (RIF) women without thrombophilia undergoing freeze-thaw embryo transfer (FET) cycles. A total of 392 FET ...
The correlation between vaginal microbiome dysbiosis and recurrent spontaneous abortion [0.03%]
阴道微生态失调与反复自然流产的相关性研究进展
Mengzhen Zheng,Weiwei Lun,Pengran Wang et al.
Mengzhen Zheng et al.
In recent years, the role of the vaginal microbiota in pregnancy maintenance has garnered increasing attention. Extensive research indicates that vaginal dysbiosis is closely associated with various adverse pregnancy outcomes, including ect...
History of the decline and repositioning of the H-Y antigen: From sex determination to reproductive immunology [0.03%]
H-Y抗原的兴衰史：从性别决定到生殖免疫学
Satoshi Hayakawa,Yoko Fujita-Yamaguchi,Shihoko Komine-Aizawa
Satoshi Hayakawa
Sex determination is a fundamental process in mammalian biology whose conceptual interpretation has evolved with advances in experimental science. Classical thought, influenced by Aristotelian philosophy, viewed femaleness as an incomplete ...
EP4 regulates glycolysis and dendritic cell maturation in unexplained recurrent miscarriage [0.03%]
EP4调节糖酵解及不明原因反复自然流产患者树突状细胞的成熟
Lin Peng,Chang Liu,Yao Ye et al.
Lin Peng et al.
Unexplained recurrent miscarriage (uRM) is associated with immune dysregulation at the maternal-fetal interface, where dendritic cell (DC) maturation imbalance may play vital roles. This study investigates how prostaglandin E2 receptor EP4 ...
FOXP3 isoform expression (Full-length and Delta 2) & immunoregulatory markers (Tregs, IL-6, IL-10) in recurrent pregnancy loss: A South-Indian study [0.03%]
FOXP3亚型（全长和Δ2）及免疫调节标志物（Tregs、IL-6、IL-10）在复发性流产中的表达：一项南印度的研究
Sufaya Jameel,Rashmi Bhuwalka,Parveen Jahan
Sufaya Jameel
Recurrent Pregnancy Loss (RPL), a complex reproductive disorder, with 50% of cases lacking a definitive cause. Immune dysregulation, particularly involving regulatory T cells (Tregs) and their master transcription factor FOXP3, is increasin...
RNF145 promotes inflammation in recurrent spontaneous abortion through inducing the K63-linked polyubiquitination of IRF3 [0.03%]
RNF145通过诱导IRF3的K63连接多泛素化促进复发性自发流产炎症
Yuqin Chen,Lin Zheng,Haiyan Gao et al.
Yuqin Chen et al.
Recurrent spontaneous abortion (RSA) is associated with the dysregulation of type Ⅰ interferon (IFN-I) and inflammatory responses. Here, we revealed that IFN-Is and inflammation were upregulated in villus tissues from RSA patients, accompa...
Metabolic-immune axis in pregnancy: Implications for women with autoimmune diseases [0.03%]
妊娠代谢免疫轴在自身免疫性疾病妇女中的意义
Xiaoyu Ding,Libao Liu,Yonggang Zhou
Xiaoyu Ding
A healthy pregnancy involves a series of physiological adaptations in both the immune and metabolic systems, which interact closely through the "metabolism-immune axis." Metabolic remodeling during pregnancy dynamically modulates immune cel...
Rewiring the inflammatory microenvironment to reverse ovarian failure: Immunomodulatory implications of finerenone [0.03%]
重塑炎症微环境以逆转卵巢功能衰竭：芬戈利蒙特的免疫调节意义
Kuan-Hao Tsui,Chia-Jung Li
Kuan-Hao Tsui
Recent evidence suggests that the nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone restores folliculogenesis and fertility in premature ovarian insufficiency (POI) by reversing ovarian stromal fibrosis. While structural re...
The main active monomer of Dan'e-fukang soft extract, liquiritin, inhibits the inflammation and invasion of ectopic endometrial stromal cells through down-regulation of CCL2 [0.03%]
丹莪茯康软胶囊有效部位活性单体甘草素通过下调CCL2抑制子宫内膜异位症病灶炎症及侵袭能力
Xi Yang,Ji Li,Chen Wang et al.
Xi Yang et al.
The study explored the mechanism of Dan'e-fukang soft extract in treating endometriosis (EMs) through network pharmacology. The main active ingredients of Dan'e-fukang soft extract were analyzed based on the traditional Chinese medicine sys...