Ameliorative Effects of Total Glycosides from Aralia elata on Airway Inflammation and Mucus Hypersecretion in Asthmatic Mice [0.03%]
Aralia elata总皂苷改善小鼠哮喘气道炎症及黏液高分泌的作用研究
Shaohua Li,Yuhuai Long,Shuai Chen et al.
Shaohua Li et al.
Ethnopharmacological relevance: Asthma, a chronic inflammatory respiratory disease, is a growing public health concern. Aralia elata (Miq.) Seem, a medicinal plant widely used in East Asia, has traditional applications in...
Hedyotis diffusa Willd. extract alleviates CCl4-induced liver fibrosis via modulation of the gut microbiota and FXR/SHP/CYP7A1-mediated bile acid metabolism [0.03%]
一枝黄花提取物通过调节肠道微生物和FXR/SHP/CYP7A1介导的胆汁酸代谢缓解四氯化碳诱导的肝纤维化
Cheng Wang,Min Luo,Qixiang Chen et al.
Cheng Wang et al.
Ethnopharmacological relevance: Liver fibrosis is a critical stage in the progression of chronic liver diseases, yet effective therapeutic agents are limited. Hedyotis diffusa Willd., a traditional Chinese medicine herb w...
Integrating network pharmacology and experimental validation to elucidate the mechanism of Xiao-bi decoction in psoriasis treatment: Inhibition of JAK2/STAT3 signaling and rebalancing Th17/Treg responses [0.03%]
基于网络药理学和实验验证的消痹汤治疗银屑病机制研究：抑制JAK2/STAT3信号转导及调节Th17/Treg平衡
Changhui Wen,Xiaoqiong Yang,Yue Han et al.
Changhui Wen et al.
Ethnopharmacological relevance: The traditional Chinese herbal medicine called Xiao-bi decoction (XBD) has been used for decades to treat psoriasis, but its mechanism of action is poorly understood. ...
Aloperine exerts anti-ovarian cancer effects by regulating the tricarboxylic acid cycle and glycolysis: A comprehensive study integrating network pharmacology, molecular docking, metabolomics, and experimental validation [0.03%]
网络药理学、分子对接、代谢组学和实验验证整合研究 aloperine通过调节三羧酸循环和糖酵解发挥抗卵巢癌作用：一项综合研究
Dan Zhang,Qianrui Yang,Huidong Xia et al.
Dan Zhang et al.
Ethnopharmacological relevance: Aloperine (ALO), an alkaloid derived from Sophora alopecuroides L., demonstrates therapeutic potential against malignant tumors, while the role of ALO and its molecular mechanisms in ovaria...
Paeonol alleviates atherosclerosis by inhibiting CD8+ T-cell activation via targeting the SYK/NFATc1 signaling pathway in ApoE-/- mice [0.03%]
芍药醇通过靶向SYK/NFATc1信号通路抑制CD8+T细胞活化缓解阿普利酮基因敲除小鼠动脉粥样硬化
Yulong Yang,Ting Zhang,Lishun Dong et al.
Yulong Yang et al.
Ethnopharmacological relevance: Moutan Cortex, a traditional Chinese medicine, has been used to treat cardiovascular diseases. Paeonol (Pae), a key bioactive compound, is responsible for its anti-atherosclerotic effects. ...
Advances on botanicals targeting programmed cell death in acetaminophen-induced liver injury [0.03%]
针对对乙酰氨基酚致肝损伤的细胞凋亡的植物药研究进展
Yujia Ge,Na Luo,Mengyi Zhang et al.
Yujia Ge et al.
Ethnopharmacological relevance: Acetaminophen (APAP), a widely used analgesic and antipyretic drug, poses a significant clinical challenge worldwide due to its potential to induce hepatotoxicity following overdose. At pre...
Unraveling the therapeutic mechanisms of Polygonum cuspidatum in pulmonary fibrosis: Modulation of M2 macrophage polarization and glycolysis pathways [0.03%]
虎杖治疗肺纤维化的机制研究：M2型巨噬细胞极化和糖酵解途径的调控作用
Yini Gao,Chester Yan Jie Ng,Kaiwen Ni et al.
Yini Gao et al.
Ethnopharmacological relevance: Polygonum cuspidatum (PC), a plant widely distributed in East Asia, is traditionally used for respiratory diseases and is documented in the "Compendium of Materia Medica" as having heat-cle...
Study on the anti- pulmonary fibrosis mechanism of Renshen Pingfei formula by inhibiting M2 macrophage polarization and regulating TGF - β/SMAD signaling pathway [0.03%]
人参平肺方抑制M2型巨噬细胞极化及调控TGF-β/SMAD信号通路的抗肺纤维化机制研究
Lingling Hong,Yubo Sun,Haihui Hou et al.
Lingling Hong et al.
Ethnopharmacological relevance: Renshen Pingfei formula (RSPF), a traditional Chinese medicine (TCM) formulation,has been historically prescribed in China for treating "Fei Bi" (pulmonary stagnation syndrome), which sympt...
Jianpi Fuzheng Xiaoji Formula Ameliorates Gastric Precancerous Lesions via Suppression of Neutrophil Extracellular Trap Formation [0.03%]
健脾扶正消积方通过抑制中性粒细胞胞外陷阱形成改善胃癌前病变
Yunshuo Zhang,Yixuan Wang,Xin Wang et al.
Yunshuo Zhang et al.
Ethnopharmacological relevance: Gastric precancerous lesions (GPL), the inflammation-driven precursors of gastric cancer (GC), may be propelled by neutrophil extracellular traps (NETs). Jianpi Fuzheng Xiaoji formula (JPFZ...
Mechanistic insights into the antidepressant effects of the Angelica sinensis and Ligusticum chuanxiong Herb Pair: Involvement of the PI3K/AKT signaling pathway [0.03%]
当归和川芎药对的抗抑郁作用机制研究：涉及PI3K/AKT信号通路
Tong Yi Yang,Xiang Ming Sun,Zhi Wei Xiong et al.
Tong Yi Yang et al.
Ethnopharmacological relevance: The Angelica sinensis and Ligusticum chuanxiong Herb Pair (DC) serves as a core pairing in Traditional Chinese Medicine for treating blood stasis and blood deficiency syndromes, which are f...