Chaihu Shugan San exerts antidepressant effects in female mice by suppressing hippocampal IL-6 and activating the cAMP-CaMKII-BDNF pathway [0.03%]
柴胡舒肝散通过抑制海马区白细胞介素-6和激活cAMP-CaMKII-BDNF信号通路发挥雌鼠抗抑郁作用
Xiangfei Liu,Banxin Luo,Li Gao et al.
Xiangfei Liu et al.
Ethnopharmacological relevance: Chaihu Shugan San (CSS), a classical Traditional Chinese Medicine (TCM) formula, was first recorded in Jingyue Quanshu (1624 AD) for treating "liver qi stagnation" (Yu Syndrome), a TCM diag...
Phyllanthin Targets GBP5 to Suppress Macrophage M1 Polarization and Alleviate DSS-Induced Colitis in a Murine Model [0.03%]
鬼臼茋通过靶向GBP5抑制巨噬细胞M1极化从而缓解小鼠DSS诱导的结肠炎
Lixia Yin,Zhijun Geng,Keni Zhang et al.
Lixia Yin et al.
Ethnopharmacological relevance: In traditional practice, Phyllanthus species are utilized to address gastrointestinal ailments, including dysentery and diarrhea. A major bioactive lignan, Phyllanthin (PHY), which is a sub...
Exploring the Molecular Mechanism of Shenling Baizhu Formula in the Treatment of Ulcerative Colitis via the cGMP-PKG Signaling Pathway [0.03%]
从cGMP-PKG信号通路探讨参苓白术散治疗溃疡性结肠炎的分子机制研究
Junlei Chen,Yan Chen,Hongbo Zheng et al.
Junlei Chen et al.
Ethnopharmacological relevance: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by symptoms such as persistent diarrhea. Shenlingbaizhu Formula (SLBZ), a classical Chinese herbal formula with...
Chemo-preventive and anti-inflammatory potential of Bilvamoola [Aegle marmelos (L.) Correa] root extract and its bioactive: Chemical standardization, in-vitro and in-silico validation [0.03%]
圣罗勒(Eugenia jambolana)的化学标准化、体外和分子验证：抗癌与抗炎潜力及其生物活性成分标准
Ramdas,Neerja Tiwari,Aman Chandra Kaushik et al.
Ramdas et al.
Ethnopharmacological relevance: Aegle marmelos (L.) Correa (family Rutaceae) is indigenous to India and is recognized for its use in traditional medicine, with more than 300 codified single- and compound-formulations for ...
Inonotus obliquus (Ach. ex Pers.) Pilát aqueous extract alleviates acute cold exposure/rewarming-induced myocardial injury by regulating mitochondrial dynamics via liver kinase B1/adenosine monophosphate-activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator-1 alpha signaling pathway activation [0.03%]
通过肝激酶B1/AMP激活的蛋白激酶/PPARγ共激动剂1信号途径调节线粒体动力学缓解刺子网多孔菌水提物对急性冷暴露/复温引起的心肌损伤的作用
Miao Yu,Wenwen Fu,Shuting Feng et al.
Miao Yu et al.
Ethnopharmacological relevance: Acute cold exposure affects the cardiovascular system substantially. Inonotus obliquus (Ach. ex Pers.) Pilát (IO), commonly referred to as "Chaga" in Russian traditional medicine, is a fun...
Yanxiao Di'naer decoction attenuates metabolic dysfunction-associated steatohepatitis through the regulation of gut microbiota and the metabolism of bile acid [0.03%]
阎晓芳涤乃尔汤通过调节肠道菌群和胆汁酸代谢治疗与代谢功能障碍相关性steatohepatitis
Dong-Xuan Zheng,Yu Wang,Qiang Hou et al.
Dong-Xuan Zheng et al.
Ethnopharmacological relevance: Metabolic dysfunction-associated steatohepatitis (MASH), a chronic liver disease characterised by ballooning degeneration of hepatocytes, inflammation and fibrosis, has become a global heal...
Buyanghuanwu decoction (BYHWD) attenuates hepatic fibrosis in CCl4-induced mice by regulating bile acid metabolism through activating PPARα [0.03%]
补阳还五汤通过激活PPARα调节胆汁酸代谢从而缓解四氯化碳所致小鼠肝纤维化
Xia Wei,Zikang Wang,Jiao Wang et al.
Xia Wei et al.
Ethnopharmacological relevance: Buyanghuanwu decoction (BYHWD), a classical Traditional Chinese Medicine (TCM) formula, has been widely used for treating cardiovascular and cerebrovascular diseases in China. Accumulating ...
Momordin Ic alleviates inflammation and skin barrier dysfunction of atopic dermatitis in vitro and in vivo [0.03%]
momordin Ic 体内外缓解特应性皮炎炎症和皮肤屏障功能障碍研究
Niuniu Yang,Huijuan Dai,Han Jin et al.
Niuniu Yang et al.
Ethnopharmacological relevance: Kochiae Fructus is a traditional herbal medicine used to treat a variety of skin conditions. Momordin Ic, the main bioactive pentacyclic triterpenoid saponin component of Kochiae Fructus, i...
Sijunzi decoction alleviates cancer cachexia myatrophy by suppressing M2 polarization of tumor-associated macrophages via the MCT1/lactate/H3K18 lactylation pathway [0.03%]
四君子汤通过MCT1/乳酸/H3K18乳酰化信号通路抑制肿瘤相关巨噬细胞M2极化从而改善癌症恶病质肌少症
Dengyun Nie,Yakun Zhang,Rong Jia et al.
Dengyun Nie et al.
Ethnopharmacological relevance: Chinese expert consensus shows that Sijunzi decoction (SJZD) can improve cancer cachexia myatrophy (CCMA) in clinical, but its mechanism remains unclear. ...
Multifaceted neuroprotective role of Buchanania lanzan seeds in diabetic neuropathy: In vivo and in silico studies [0.03%]
鲍欢树种子对糖尿病神经病变的多重神经保护作用：体内和计算机模拟研究
Neelam Meher,Bikash Kisan,Sandeep Kumar Swain et al.
Neelam Meher et al.
Ethnopharmacological relevance: Buchanania lanzan Spreng. (Anacardiaceae) seeds (BLHA) are the cheaper alternative to almonds used in the confectionery industry. The flour powder of seeds is used as a thickening agent to ...