Phytochemical profiling and system-level mechanistic insights into the anti-arthritic activity of Barleria cristata: Evidence from in-silico network pharmacology, molecular docking, in-vitro and in-vivo studies [0.03%]
Subhasish Sahoo,Sandesh Kumar Pattanaik,Paresh Kumar Barad et al.
Subhasish Sahoo et al.
Ethnopharmacological relevance: Barleria cristata L. is traditionally used in Indian ethnomedicine to treat inflammation, joint pain, and arthritis. Although it is widely used in traditional medicine to manage inflammator...
Sanhuang Xiexin Decoction Ameliorates Gastric Ulcers by Activating EGFR/PI3K/AKT Pathway Based on "Drug-Target-Metabolite" Network [0.03%]
Xinyu Liu,Xueyuan Wu,Hao Wang et al.
Xinyu Liu et al.
Ethnopharmacological relevance: The classical herbal formulation, Sanhuang Xiexin Decoction (SHXD), has been widely used to treat peptic ulcers. However, its specific therapeutic mechanism in gastric ulcer (GU) remains un...
Role of PTP1B in coordinating synaptic plasticity and ferroptosis: A mechanism underlying the antidepressant effect of spinosin from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou [0.03%]
Yanmei Wang,Yueyue Zhang,Junming Wang et al.
Yanmei Wang et al.
Ethnopharmacological relevance: Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou (Ziziphi Spinosae Semen, ZSS), a traditional ethnic medicine for treating neurological disorders including depression, is a key c...
Mechanism of Inonotus hispidus in treating melasma: integrated in vivo, in vitro, network pharmacology and untargeted metabolomics investigation [0.03%]
Jingnan Li,Haiying Bao,Songhe Jia et al.
Jingnan Li et al.
Ethnopharmacological relevance: Inonotus hispidus (Bull.) P. Karst. is a traditional Chinese medicine (TCM) with a long history. Although its use in treating melasma was documented in the Bencaogangmu, its therapeutic mec...
Quercetin enhances skin flap survival via SIRT1-regulated mitophagy promotion and pyroptosis inhibition [0.03%]
An Wang,Sihan Chen,Jialong Yang et al.
An Wang et al.
Ethnopharmacological relevance: Flap necrosis remains a prevalent and challenging complication in reconstructive surgery. Quercetin (QUE), a primary bioactive flavonoid found in the traditional Chinese medicine Sophora ja...
Ginsenoside Rg2 delays brain aging via inhibiting α-synuclein expression and promoting FoxO-Mediated neurogenesis in mice [0.03%]
Junjie Zhang,Jingwen Niu,Shaojie Yang et al.
Junjie Zhang et al.
Ethnopharmacological relevance: Panax ginseng C.A. Meyer (ginseng) has been utilized in East Asian medicine for centuries to enhance cognitive function, improve memory, and mitigate age-related decline. Ginsenoside Rg2, a...
Investigating the mechanism of Rehmannia glutinosa-Ephedra sinica in heart failure with preserved ejection fraction by network pharmacology, metabolomics and experimental validation [0.03%]
Yu Cao,Sudan Li,Yi Zhang et al.
Yu Cao et al.
Ethnopharmacological relevance: Rehmannia glutinosa and Ephedra sinica (MD), herbs from the classical formula Yanghe Decoction, have been used to nourish yin, enrich blood and promote diuresis. Their traditional indicatio...
Multi-target mechanisms of Banxia Baizhu Tianma Decoction against MASH in a methionine-choline deficient mouse model: insights from a Multi-Omics Investigation [0.03%]
Qinying Feng,Lili Gao,Jiewen Shi et al.
Qinying Feng et al.
Ethnopharmacological relevance: This study aims to systematically evaluate the therapeutic effects of the classic Chinese herbal formula Banxia Baizhu Tianma Decoction (BBTD) on a methionine-choline-deficient (MCD) diet-i...
Anti-inflammatory and pain-relieving effects of Gentiana lutea leaf and Gentianella crispata aerial part extracts in adjuvant-induced arthritis in rats [0.03%]
Jelena Živković,Syed Abdul Rafay,Talha Yaseen et al.
Jelena Živković et al.
Ethnopharmacological relevance: Different gentian preparations are used as traditional remedies for internal pain control. However, comparative data on different Gentiana species are scarce, and their therapeutic potentia...
Mechanism of N-butanol extract of Pulsatilla decoction protected vaginal epithelial cells against Candida albicans infection by HIF-1α signaling and glucose metabolism revealed by transcriptomics and molecular docking [0.03%]
Faqiong Chu,Hui Wu,Can Li et al.
Faqiong Chu et al.
Ethnopharmacological relevance: Infection of vaginal epithelial cells by Candida albicans (C. albicans) can cause vulvovaginal candidiasis (VVC). Pulsatilla decoction has been reported and used to treat VVC, but the speci...