Spatial metabolomics reveals the therapeutic mechanisms of Shengjiang Xiexin decoction in modulating gut-liver axis fatty acid metabolism for the treatment of Clostridioides difficile infection [0.03%]
Yue Xu,Yutao Cui,Fuzhi Ma et al.
Yue Xu et al.
Ethnopharmacological relevance: Shengjiang Xiexin Decoction (SXD) is a classic formula documented in the Treatise on Cold Damage and Miscellaneous Diseases. It has long been used to treat infectious gastrointestinal disea...
Linderalactone attenuates pulmonary fibrosis by suppressing HIF-1α-associated ferroptotic stress [0.03%]
Mengjie Qiu,Xiao Zhou,Aofeng Sun et al.
Mengjie Qiu et al.
Ethnopharmacological relevance: Linderalactone is a sesquiterpene lactone isolated from Linderae Radix, a traditional Chinese medicinal herb used for pain and inflammatory disorders. Given the roles of hypoxia-related sig...
Acute developmental toxicity and cardiotoxicity of Physalis alkekengi L. fruit and calyx extracts based on zebrafish (Danio rerio) model [0.03%]
Zhuoshuo Zhou,Weirong Sun,Liye Yang et al.
Zhuoshuo Zhou et al.
Ethnopharmacological relevance: Physalis alkekengi L. (P. alkekengi) is widely used in traditional medicine and functional foods for its various medicinal properties. However, its toxicological profile has not been compre...
Antimalarial compounds from Solanum nigrum: In vitro antiplasmodial evaluation and network pharmacology-based investigation of host immunomodulatory mechanisms [0.03%]
Appolinaire Tapche Fossouo,Gervais Mouthé Happi,Alain Tadjong Tcho et al.
Appolinaire Tapche Fossouo et al.
Ethnopharmacological relevance: Malaria is a significant global health issue, made worse by the growing resistance of Plasmodium falciparum to current antimalarial drugs. This highlights the need for new, safe, and multi-...
Entadamide A-β-D-glucopyranoside Attenuates Psoriatic Dermatitis by Restoring Keratinocyte Homeostasis and Suppressing Neutrophil Extracellular Traps [0.03%]
Zhi-Hong Zhang,Xiang-Yuan Wang,Shu-Lin Quan et al.
Zhi-Hong Zhang et al.
Ethnopharmacological relevance: The seeds of Entada phaseoloides (L.) Merr. is a well-established traditional Chinese medicine (TCM) and Dai Medicine historically utilized for treating inflammatory skin conditions like de...
Arthrospira platensis prevents impairment of intestinal smooth muscle relaxation in diet-induced obesity via modulation of nitric oxide, prostanoid and oxidative stress pathways [0.03%]
Ray Ravilly Alves Arruda,Michel Benício de Melo,José Edvaldo Cavalcanti de Sousa Filho et al.
Ray Ravilly Alves Arruda et al.
Ethnopharmacological relevance: Arthrospira platensis (Spirulina) has been traditionally consumed in Africa, Asia and Central America as a nutrient-rich restorative food associated with metabolic balance and gastrointesti...
Taohong Siwu decoction mitigates abnormal uterine bleeding by suppressing ferroptosis in endometrial epithelial cell through p38MAPK signaling pathway [0.03%]
Yanling Zhao,Mengyu Su,Yao Cheng et al.
Yanling Zhao et al.
Ethnopharmacological relevance: Abnormal uterine bleeding (AUB) represents a prevalent gynecological disease. Taohong Siwu Decoction (TSD), a classic formula originating from the Qing Dynasty medical text "Yizong Jinjian"...
Capsaicinoids prevent intestinal fluid secretion and motility by inhibiting chloride channels [0.03%]
Fangfang Sun,Bo Yu,Ruifang Xie et al.
Fangfang Sun et al.
Ethnopharmacological relevance: In traditional Chinese medicine, chili peppers and their seeds have been utilized for the treatment of watery diarrhea and malaria. Capsaicinoids, as the major bioactive compounds of these ...
Zeinoside B, a pregnane glycoside from Caralluma adenensis (Defler) A. Berger, accelerates excisional wound healing in mice through antioxidant and reparative mechanisms [0.03%]
Ola E Abdel-Sattar,Riham A El-Shiekh,Manal M Sabry et al.
Ola E Abdel-Sattar et al.
Ethnopharmacological relevance: Wound healing is a complex and coordinated process that includes phases of hemostasis, inflammation, proliferation, and remodeling. Caralluma adenensis (Defler) A.Berger is ethnomedicinal p...
Identifying the active components and mechanisms of Toona sinensis pericarps for the treatment of diabetic kidney disease using network pharmacology and experimental verification [0.03%]
Yufeng Zhang,Huiting Li,Weining Sun et al.
Yufeng Zhang et al.
Ethnopharmacological relevance: Toona sinensis is used to treat diabetic kidney disease (DKD). However, the potential bioactive components and effects of T. sinensis pericarps dichloromethane extracts (DCME) on DKD are po...