Fenfluramine for developmental and epileptic encephalopathy with spike-wave activation in sleep (DEE-SWAS): An exploratory study [0.03%]
用于睡眠中出现尖波放电的发育性和癫痫性脑病(DEE-SWAS)的芬氟拉明：一项探索性研究
Paloma Parra-Díaz,Antonio Gil-Nagel,Irene Sánchez-Miranda Román et al.
Paloma Parra-Díaz et al.
Objective: To evaluate the safety and potential efficacy of fenfluramine (FFA) in patients with developmental and epileptic encephalopathy with spike-and-wave activation in sleep (DEE-SWAS). ...
Effectiveness and tolerability of perampanel as first add-on treatment in pediatric patients with focal and generalized epilepsy [0.03%]
托吡酯作为儿童局灶性和全面性癫痫的一线添加治疗的有效性和耐受性研究
Bárbara Blanco Martínez,Elena Arce Portillo,María Muñoz Cabeza et al.
Bárbara Blanco Martínez et al.
Purpose: To compare the effectiveness and safety of perampanel as first add-on vs. late add-on therapy in children with focal or generalized epilepsy. Met...
Trends, prescribing patterns and projections of antiseizure drug use in Europe [0.03%]
欧洲各国的抗癫痫药物使用趋势、用药模式及预测
Lilly Josephine Bindel,Roland Seifert
Lilly Josephine Bindel
Purpose: Epilepsy represents a significant global burden, with antiseizure drugs (ASDs) essential for treatment. This study examines past and recent trends in ASD consumption in 11 European countries, forecasts future dev...
Histological and electrophysiological effects of sulbactam and valproate in the PTZ-induced epileptic rat model [0.03%]
硫鸟嘌呤和丙戊酸对PTZ诱导的癫痫大鼠模型组织学及电生理学的影响
Yun-Ju Hsieh,Fang-Chia Chang,Chiung-Hui Liu et al.
Yun-Ju Hsieh et al.
An imbalance between excitatory glutamate and inhibitory gamma-aminobutyric acid (GABA) neurotransmitters is a key mechanism in epilepsy. Astrocytic glutamate transporter-1 (GLT-1) helps reuptake glutamate in the synaptic cleft to maintain ...
Altered synaptic functions in a humanized mouse model of down syndrome (TcMAC21): Implications for seizure susceptibility [0.03%]
唐氏综合征人类化小鼠模型(TcMAC21)中突触功能改变：对癫痫易感性的意义
Li-Rong Shao,Carl E Stafstrom
Li-Rong Shao
It is not understood why children with Down syndrome (DS, trisomy of chromosome 21) have an increased risk of seizures, including infantile spasms and tonic-clonic seizures. Using a novel humanized mouse model of DS (TcMAC21), we recently s...
Epilepsy in children and adolescents with B-cell acute lymphoblastic leukemia [0.03%]
儿童及青少年B细胞急性淋巴细胞白血病患者癫痫发作风险增加
Sun Ah Choi,Aditi Trivedi,Daanish Unwalla et al.
Sun Ah Choi et al.
Objective: This study aims to evaluate seizure outcomes and identify predisposing factors for epilepsy in patients diagnosed with B-cell acute lymphoblastic leukemia (B-ALL). ...
Reassessing anhedonia in Genetic Absence Epilepsy: Sucrose preference unaltered by spike-wave discharges in WAG/Rij rats [0.03%]
遗传性缺失癫痫中欣快感缺乏的再评估：WAG/Rij大鼠的糖水偏爱不受尖峰波放电的影响
Maria Pupikina,Evgenia Sitnikova
Maria Pupikina
Anhedonia, characterized by reduced pleasure or interest, is linked to various neurological disorders, including genetic epilepsies. Previous studies in genetic rat models of absence epilepsy, such as WAG/Rij rats, have reported anhedonia-l...
Deep brain stimulation of the anterior nucleus of the thalamus in animal models of mesial temporal lobe epilepsy: A literature review [0.03%]
丘脑前核深部脑刺激在内侧颞叶癫痫动物模型中的应用：文献回顾
Emma Acerbo,Thomas Eggers,Alejandra M Fernandez et al.
Emma Acerbo et al.
Epilepsy affects approximately 1 % of the global population, presenting as a complex and heterogeneous disorder characterized by spontaneous, recurrent seizures. Focal onset seizures comprise half of all epilepsy cases. Mesial temporal lobe...
Author response: Seizure outcome and anti-seizure medication use in post-stroke epilepsy: A retrospective cohort study [0.03%]
作者回应：卒中后癫痫的发作结局和抗癫痫药物应用：一项回顾性队列研究
Ahmed Khadija,Jacques Theitler,Revital Gandelman-Marton
Ahmed Khadija