Automated detection of the epileptogenic zone in stereoelectroencephalography for drug-resistant epilepsy using multi-epileptogenic biomarker machine learning [0.03%]
基于多癫痫发生生物标志物机器学习的立体脑电图癫痫灶自动化检测算法研究（难治性癫痫）
Chuan Du,Weipeng Jin,Le Wang et al.
Chuan Du et al.
Objective: Neurosurgery is a viable treatment option for patients with drug-resistant epilepsy (DRE), where accurate localization of the epileptogenic zone (EZ) is crucial for surgical success. This study aims to develop ...
Predictors of surgical outcome in frontal lobe epilepsy: Experience from a single-center cohort in Latin America [0.03%]
拉美单中心额叶癫痫手术疗效的预测因素：一家医院的经验总结
Diana Margoth Riaño-Carreño,Andrés Felipe Cardenas,Jacobo Ramirez-Triana et al.
Diana Margoth Riaño-Carreño et al.
Background: Frontal lobe epilepsy (FLE) is the second most common type of focal epilepsy and among the most challenging to diagnose and treat. Although surgical resection offers potential seizure freedom, outcomes vary, a...
Real-world evidence on the use of new antiseizure medications in brain tumor-related epilepsy [0.03%]
抗癫痫新药在脑肿瘤相关性癫痫中的实际应用证据
Nasim Tabrizi,Mehran Frouzanian,Sajad Shafiee et al.
Nasim Tabrizi et al.
Objective: Brain tumor-related epilepsy (BTRE) is a common and disabling complication of primary brain tumors. While older antiseizure medications (ASMs) are limited by adverse effects and drug interactions, newer ASMs su...
Surgery for epilepsy secondary to vascular insults: A systematic review and meta-analysis of individual patient data [0.03%]
血管性继发性癫痫的手术治疗：个体患者数据的系统评价和meta分析
Adrian E Jimenez,Neil A Feldstein,Guy M McKhann et al.
Adrian E Jimenez et al.
Background: While epilepsy secondary to vascular insults represents a well-documented cause of drug-resistant epilepsy that requires surgical intervention for optimal management, the prognostic factors for postoperative s...
Long-term administration of EQU-001 (ivermectin) suppresses spasms in a rat model of infantile epileptic spasms syndrome [0.03%]
埃奎德001(伊维菌素)长期给药可抑制婴儿期癫痫性痉挛综合征大鼠模型的痉挛发作
Chian-Ru Chern,Antonia Schonwald,Kayla Vieira et al.
Chian-Ru Chern et al.
We investigated effects of long-term and acute administration of EQU-001 (ivermectin) against NMDA-triggered spasms in immature rats prenatally exposed to betamethasone and in the model of infantile epilepsy spasms syndrome (IESS). Pregnant...
Allostatic load of immune cells in the spleen and brain of the Kcna1-null mouse model of temporal lobe epilepsy [0.03%]
Kcna1基因敲除小鼠海马和脾脏免疫细胞的代偿负荷研究
Jillian E Hinman,Ankita Aggarwal,Amberlee Haggerty et al.
Jillian E Hinman et al.
Human temporal lobe epilepsy (TLE), particularly drug-resistant TLE, is associated with chronic peripheral immune activation. Here, we determined whether a similar association was detectable in a genetic mouse model of TLE with spontaneous ...
The effectiveness and safety of lacosamide in infants with epilepsy aged under 2 years: A prospective study [0.03%]
拉考沙胺治疗2岁以下婴幼儿癫痫的疗效和安全性：一项前瞻性研究
Liu Tailin,Xiong Li,Liu Jing et al.
Liu Tailin et al.
Objective: To evaluate the effectiveness and safety of lacosamide (LCM) in children with epilepsy aged 1 month to 2 years, including those with developmental epileptic encephalopathy (DEE), and to identify risk factors in...
The utility of ketogenic diet therapy in the management of epileptic spasms: A systematic review and meta-analysis [0.03%]
生酮饮食治疗癫痫痉挛的疗效：系统评价和.meta.分析
Gabriella Yakemow,Stephanie Aleluya,Rajesh Ramachandrannair et al.
Gabriella Yakemow et al.
Objective: We systematically reviewed the existing literature on the efficacy of the ketogenic diet (KD) in patients with epileptic spasms (ES) and analyzed predictors of seizure outcomes. ...
Hendriëtte van Loo-Flier,Christoph Stephan Dietze,Anne Marthe Meppelink
Hendriëtte van Loo-Flier
Objective: To investigate whether Tailored Provocation (TP) can result in habitual seizures during electroencephalogram (EEG) recording in patients with a probable diagnosis of functional seizures (FS) and if future resea...
Multimodal diagnostic concordance and seizure outcomes following stereo-encephalography-guided volumetric radiofrequency thermocoagulation in drug-resistant epilepsy [0.03%]
立体脑电图引导的体积射频热凝固治疗难治性癫痫的多模态诊断符合率及发作结局
Zhimin Xu,Stéphane Jean,Yihai Dai et al.
Zhimin Xu et al.
Objective: To evaluate the relationship between multimodal diagnostic concordance and postoperative seizure outcomes in patients with drug-resistant epilepsy (DRE) undergoing stereo-electroencephalography (SEEG)-guided vo...