Assessing an fMRI-guided titration paradigm for microburst VNS therapy [0.03%]
基于fMRI的微爆发式VNS治疗滴定方案评估
Kristl Vonck,Ryan Verner,Giovanni Ranuzzi et al.
Kristl Vonck et al.
Rationale: VNS is an efficacious therapy for people with epilepsy (PwE), but personalized implementation of VNS dosing and titration could be improved by measuring therapeutic engagement of cortical and subcortical physio...
Healthcare resource utilization in adults with focal onset seizures before and after initiating cenobamate: A US database analysis [0.03%]
成人局灶性发作性癫痫患者在使用cenobamate之前的医疗资源利用情况及其后的变化：一项美国数据库分析
Alessandro Lovera,Elena Alvarez-Baron,Rafia Bosan et al.
Alessandro Lovera et al.
Background: Antiseizure medications (ASMs) are the mainstay of treatment for patients with epilepsy, though over one third remain uncontrolled after treatment with at least two ASMs. Cenobamate is an ASM indicated for the...
Seizure recurrences after temporal lobe epilepsy surgery in childhood and adolescence: predictive factors, patterns of recurrence, and long-term outcomes [0.03%]
儿童和青少年颞叶癫痫手术后复发的预测因素、发作模式及长期预后
Ming-Chen Tsai,Keith Starnes,Anthony L Fine et al.
Ming-Chen Tsai et al.
Background: Temporal lobe epilepsy (TLE) is the leading cause of drug-resistant focal epilepsy. Surgery is effective, yet many patients experience postoperative seizure recurrence. ...
Status epilepticus in scrub typhus versus tuberculous meningitis: A comparative study [0.03%]
登革热和结核性脑膜炎引起的癫痫持续状态的比较研究
Jayantee Kalita,Firoz M Nizami,Prakash C Pandey et al.
Jayantee Kalita et al.
Background: Scrub typhus (ST) and tuberculous meningitis (TBM) are common infections in tropical regions and can present with various neurological manifestations, including seizures and status epilepticus (SE). This study...
A systematic review of highly purified cannabidiol in developmental and epileptic encephalopathies and complex treatment-resistant epilepsies: Changes in seizure frequency and adverse events [0.03%]
高纯度大麻二酚治疗发育性和难治性癫痫的系统综述：发作频率及不良事件的变化
Antonietta Coppola,Lisa Moore-Ramdin,Marco Navetta et al.
Antonietta Coppola et al.
Objective: The efficacy and safety of a highly purified plant-derived cannabidiol (CBD) oral solution (Epidiolex® [US]/Epidyolex® [EU], EPX) have been established for the treatment of seizures in patients with Lennox-Ga...
Factors influencing pediatric epilepsy outcomes: Predictive variables and adherence to clinical practice guidelines [0.03%]
影响儿科癫痫预后的因素：预测指标及临床实践指南依从性
Vaibhav R Suryawanshi,Kavita Srivastava,Anshu Priya et al.
Vaibhav R Suryawanshi et al.
Background: Pediatric epilepsy constitutes significant challenges for long-term management in resource-limited settings. This study determined factors influencing epilepsy outcomes in children (predictive variables) and a...
Sexual and developmental variability of spike-wave discharges in the taiep rat: A model of H-ABC leukodystrophy [0.03%]
Taiep大鼠棘波放电的性发育差异及变异：H-ABC白质营养不良模型
Carmen Cortes,Juan M Ibarra-Hernández,Gilles van Luijtelaar et al.
Carmen Cortes et al.
Taiep rat has a leukodystrophy caused by a tubulinopathy affecting the β-tubulin 4 A (TUBB4A) gene characterized by hypomyelination and progressive demyelination of the central nervous system. In magnetic resonance imaging taiep rats showe...
Hospitalisation burden among persons with epilepsy attending an outpatient neuroscience specialist clinic in Singapore [0.03%]
新加坡神经学专科门诊癫痫患者的住院负担
Anushika Raheja,Zhibin Tan,Kaavya Narasimhalu
Anushika Raheja
Background: Epilepsy carries significant clinical and socioeconomic burden, largely driven by hospitalisations. Although hospitalisation rates are well described internationally, data from Asia remain limited. We aimed to...
Antiseizure medication effects on sleep architecture in epilepsy: Glymphatic insights and implications for cognitive decline [0.03%]
抗癫痫药物对癫痫患者睡眠结构的影响：胶淋巴系统的新见解及其对认知衰退的含义
Justyna Swierz,Michael Doherty,Sung Ji et al.
Justyna Swierz et al.
Disruptions in sleep architecture may contribute to cognitive decline in people with epilepsy (PWE), potentially through impaired glymphatic clearance. In this narrative review, we explore how antiseizure medications (ASMs) influence key sl...
Megan Abbott,Katie Angione,Megan Stringfellow et al.
Megan Abbott et al.
8p-related disorders are genetic conditions associated with chromosomal rearrangements on the short arm of chromosome 8. This study aimed to characterize the epilepsy phenotype in patients with 8p-related disorders seen at Children's Hospit...